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HAMAP rule MF_00983

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General rule information [?]

Accession MF_00983
Dates 7-JAN-2014 (Created)
1-JUN-2023 (Last updated, Version 5)
Name PriA
Scope(s) Bacteria
Template(s) P17888 (PRIA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00983 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PRIA
case not <Feature:PS51192> and not <Feature:PS51194>
RecName: Full=Probable primosomal protein N';<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase PriA;
else
RecName: Full=Primosomal protein N';<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase PriA;
end case
Gene name Name=priA;

Comments [?]

FUNCTIONInvolved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.
SUBUNITComponent of the primosome.
SIMILARITYBelongs to the helicase family. PriA subfamily.

Keywords [?]

ATP-binding
DNA replication
DNA-binding
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>
Hydrolase
Nucleotide-binding
Primosome
case <FTTag:zinc>
Metal-binding
Zinc
Zinc-finger
end case

Gene Ontology [?]

GO:0003678; Molecular function:DNA helicase activity
GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
case <FTTag:zinc>
GO:0008270; Molecular function:zinc ion binding
end case
GO:0006268; Biological process:DNA unwinding involved in DNA replication
GO:1990077; Cellular component:primosome complex

Cross-references [?]

PROSITE PS51192; HELICASE_ATP_BIND_1; 0-1;
PROSITE PS51194; HELICASE_CTER; 0-1;
Pfam PF00270; DEAD; 1;
Pfam PF00271; Helicase_C; 1;
NCBIfam TIGR00595; priA; 1;

Features [?]

From: PRIA_ECOLI (P17888)
Key From To Description Tag Condition FTGroup
ZN_FING 436 448 /note="C4-type" zinc C-x(2)-C-x(5)-C-x(2)-C
ZN_FING 463 479 /note="C4-type" zinc C-x(2)-C-x(7,10)-C-x(2)-C

Additional information [?]

Size range 535-950 amino acids
Related rules None
Fusion Nter: None Cter: None



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