HAMAP rule MF_00983
General rule information
[?]
Accession | MF_00983 |
Dates | 7-JAN-2014 (Created)
1-JUN-2023 (Last updated, Version 5) |
Name | PriA |
Scope(s) |
Bacteria |
Template(s) | P17888 (PRIA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00983 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Identifier | PRIA |
case not <Feature:PS51192> and not <Feature:PS51194> | |
RecName: Full=Probable primosomal protein N';<br /> EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase PriA; | |
else | |
RecName: Full=Primosomal protein N';<br /> EC=<a href="https://enzyme.expasy.org/EC/3.6.4.-">3.6.4.-</a>;<br /> AltName: Full=ATP-dependent helicase PriA; | |
end case | |
Gene name | Name=priA; |
Comments
[?]
FUNCTION | Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. |
SUBUNIT | Component of the primosome. |
SIMILARITY | Belongs to the helicase family. PriA subfamily. |
Keywords
[?]
ATP-binding | |
DNA replication | |
DNA-binding | |
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
Hydrolase | |
Nucleotide-binding | |
Primosome | |
case <FTTag:zinc> | |
Metal-binding | |
Zinc | |
Zinc-finger | |
end case |
Gene Ontology
[?]
GO:0003678; Molecular function:DNA helicase activity | |
GO:0005524; Molecular function:ATP binding | |
GO:0003677; Molecular function:DNA binding | |
case <FTTag:zinc> | |
GO:0008270; Molecular function:zinc ion binding | |
end case | |
GO:0006268; Biological process:DNA unwinding involved in DNA replication | |
GO:1990077; Cellular component:primosome complex |
Cross-references
[?]
PROSITE | PS51192; HELICASE_ATP_BIND_1; 0-1; |
PROSITE | PS51194; HELICASE_CTER; 0-1; |
Pfam | PF00270; DEAD; 1; |
Pfam | PF00271; Helicase_C; 1; |
NCBIfam | TIGR00595; priA; 1; |
Features
[?]
From: PRIA_ECOLI (P17888) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ZN_FING | 436 | 448 | /note="C4-type" | zinc | C-x(2)-C-x(5)-C-x(2)-C | |||||||
ZN_FING | 463 | 479 | /note="C4-type" | zinc | C-x(2)-C-x(7,10)-C-x(2)-C |
Additional information
[?]
Size range | 535-950 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |