HAMAP rule MF_00987
General rule information
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Accession | MF_00987 |
Dates | 22-JAN-2014 (Created) 19-NOV-2022 (Last updated, Version 10) |
Name | FucA |
Scope | Bacteria |
Template | P0AB87 (FUCA_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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case <FTGroup:1>
Protein name |
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end case
case not <FTGroup:1>
Protein name |
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end case
Gene name |
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Comments
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Function | Involved in the degradation of L-fucose and D-arabinose. Catalyzes the reversible cleavage of L-fuculose 1-phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. |
Catalytic activity | RHEA:12933: L-fuculose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate
EC 4.1.2.17 |
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
Pathway | Carbohydrate degradation; L-fucose degradation; L-lactaldehyde and glycerone phosphate from L-fucose: step 3/3. |
Subunit | Homotetramer. |
Similarity | Belongs to the aldolase class II family. AraD/FucA subfamily. |
Keywords
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Gene Ontology
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GO:0008738; Molecular function: L-fuculose-phosphate aldolase activity.
GO:0008270; Molecular function: zinc ion binding.
GO:0042355; Biological process: L-fucose catabolic process.
GO:0008270; Molecular function: zinc ion binding.
GO:0042355; Biological process: L-fucose catabolic process.
Cross-references
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Features
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From: FUCA_ECOLI (P0AB87) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 28 | 29 | /ligand="substrate | G-N | ||||||||
BINDING | 43 | 44 | /ligand="substrate | [TS]-G | ||||||||
BINDING | 71 | 72 | /ligand="substrate | S-S | ||||||||
ACT_SITE | 73 | 73 | Proton donor/acceptor | E | ||||||||
BINDING | 73 | 73 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | E | 1 | |||||||
BINDING | 92 | 92 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 94 | 94 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
BINDING | 155 | 155 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic | H | 1 | |||||||
SITE | 113 | 113 | Plays a key role in the stabilization of the transition state and positioning the aldehyde component | Y | ||||||||
SITE | 131 | 131 | Plays a key role in the stabilization of the transition state and positioning the aldehyde component | F | ||||||||
SITE | 209 | 209 | Plays a key role in the stabilization of the transition state and positioning the aldehyde component | Y |
Additional information
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Size range | 195-230 amino acids |
Related rules | None |
Fusion | None |