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HAMAP rule MF_00990

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General rule information [?]

Accession MF_00990
Dates 10-FEB-2014 (Created)
28-FEB-2020 (Last updated, Version 10)
Name L_hydroxyglutarate_dehydrogenase
Scope(s) Bacteria
Template(s) P37339 (LHGD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00990 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LHGD
Protein name RecName: Full=L-2-hydroxyglutarate dehydrogenase;
                 Short=L2HG dehydrogenase;
AltName: Full=L2HG:quinone oxidoreductase;
Gene name Name=lhgD;

Comments [?]

FUNCTIONCatalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
CATALYTIC ACTIVITY Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665;
PATHWAYAmino-acid degradation.
SUBCELLULAR LOCATIONCell inner membrane.
SIMILARITYBelongs to the L2HGDH family.

Keywords [?]

Gene Ontology [?]

GO:0016901; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO:0047545; Molecular function:2-hydroxyglutarate dehydrogenase activity
GO:0050660; Molecular function:flavin adenine dinucleotide binding
GO:0019477; Biological process:L-lysine catabolic process

Cross-references [?]

Pfam PF01266; DAO; 1;

Features [?]

Additional information [?]

Size range 410-450 amino acids
Related rules None
Fusion Nter: None Cter: None

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