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| Annotation rule MF_00990 |
General rule information
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| Accession | MF_00990 |
| Dates | 10-FEB-2014 (Created) 28-FEB-2020 (Last updated, Version 10) |
| Name | L_hydroxyglutarate_dehydrogenase |
| Scope | Bacteria; Enterobacterales |
| Template | P37339 (LHGD_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
| Catalytic activity | RHEA:58664: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol
EC 1.1.5.13 PhysiologicalDirection=left-to-right (RHEA:58665) |
| Cofactor | FAD |
| Pathway | Amino-acid degradation. |
| Subcellular location | Cell inner membrane. |
| Similarity | Belongs to the L2HGDH family. |
Keywords
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Cell inner membrane
Cell membrane
Membrane
Electron transport
FAD
Flavoprotein
Oxidoreductase
Transport
Cell membrane
Membrane
Electron transport
FAD
Flavoprotein
Oxidoreductase
Transport
Gene Ontology
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GO:0016901; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor.
GO:0047545; Molecular function: 2-hydroxyglutarate dehydrogenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0019477; Biological process: L-lysine catabolic process.
GO:0047545; Molecular function: 2-hydroxyglutarate dehydrogenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0019477; Biological process: L-lysine catabolic process.
Cross-references
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| Pfam | PF01266; DAO; 1; |
Additional information
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| Size range | 410-450 amino acids |
| Related rules | None |
| Fusion | None |