HAMAP rule MF_00990
General rule information
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Accession | MF_00990 |
Dates | 10-FEB-2014 (Created)
28-FEB-2020 (Last updated, Version 10) |
Name | L_hydroxyglutarate_dehydrogenase |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P37339 (LHGD_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00990 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | LHGD |
Protein name | RecName: Full=L-2-hydroxyglutarate dehydrogenase; Short=L2HG dehydrogenase; EC=1.1.5.13; AltName: Full=L2HG:quinone oxidoreductase; |
Gene name | Name=lhgD; |
Comments
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FUNCTION | Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
CATALYTIC ACTIVITY | Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.13; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
PATHWAY | Amino-acid degradation. |
SUBCELLULAR LOCATION | Cell inner membrane. |
SIMILARITY | Belongs to the L2HGDH family. |
Keywords
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Cell inner membrane |
Cell membrane |
Membrane |
Electron transport |
FAD |
Flavoprotein |
Oxidoreductase |
Transport |
Gene Ontology
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GO:0016901; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor |
GO:0047545; Molecular function:2-hydroxyglutarate dehydrogenase activity |
GO:0050660; Molecular function:flavin adenine dinucleotide binding |
GO:0019477; Biological process:L-lysine catabolic process |
Cross-references
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Pfam | PF01266; DAO; 1; |
Features
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Additional information
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Size range | 410-450 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |