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Annotation rule MF_00990
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General rule information [?]

Accession MF_00990
Dates 10-FEB-2014 (Created)
28-FEB-2020 (Last updated, Version 10)
Name L_hydroxyglutarate_dehydrogenase
Bacteria; Enterobacterales
Template P37339 (LHGD_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=L-2-hydroxyglutarate dehydrogenase;
Short=L2HG dehydrogenase;
AltName: Full=L2HG:quinone oxidoreductase;
Gene name

Comments [?]

Function Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Catalytic activity RHEA:58664: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol
PhysiologicalDirection=left-to-right (RHEA:58665)
Cofactor FAD
Pathway Amino-acid degradation.
Subcellular location Cell inner membrane.
Similarity Belongs to the L2HGDH family.

Keywords [?]

Gene Ontology [?]

GO:0016901; Molecular function: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor.
GO:0047545; Molecular function: 2-hydroxyglutarate dehydrogenase activity.
GO:0050660; Molecular function: flavin adenine dinucleotide binding.
GO:0019477; Biological process: L-lysine catabolic process.

Cross-references [?]

Pfam PF01266; DAO; 1;

Additional information [?]

Size range 410-450 amino acids
Related rules None
Fusion None