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Annotation rule MF_00990 |
Accession | MF_00990 |
Dates | 10-FEB-2014 (Created) 28-FEB-2020 (Last updated, Version 10) |
Name | L_hydroxyglutarate_dehydrogenase |
Scope | Bacteria; Enterobacterales |
Template | P37339 (LHGD_ECOLI) |
Triggered by |
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Function | Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
Catalytic activity | RHEA:58664: (S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a quinol
EC 1.1.5.13 PhysiologicalDirection=left-to-right (RHEA:58665) |
Cofactor | FAD |
Pathway | Amino-acid degradation. |
Subcellular location | Cell inner membrane. |
Similarity | Belongs to the L2HGDH family. |
Pfam | PF01266; DAO; 1; |
Size range | 410-450 amino acids |
Related rules | None |
Fusion | None |