HAMAP rule MF_00990

General rule information [?]

Accession	MF_00990
Dates	10-FEB-2014 (Created) 3-SEP-2024 (Last updated, Version 11)
Name	L_hydroxyglutarate_dehydrogenase
Scope(s)	Bacteria Enterobacterales
Template(s)	P37339 (LHGD_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_00990 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LHGD
Protein name	RecName: Full=L-2-hydroxyglutarate dehydrogenase; Short=L2HG dehydrogenase; EC=1.1.5.13; AltName: Full=L2HG:quinone oxidoreductase;
Gene name	Name=lhgD;

Comments [?]

FUNCTION	Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG) to alpha-ketoglutarate and couples to the respiratory chain by feeding electrons from the reaction into the membrane quinone pool. Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
CATALYTIC ACTIVITY	Reaction=(S)-2-hydroxyglutarate + a quinone = a quinol + 2- oxoglutarate; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.13; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665;
COFACTOR	Name=FAD; Xref=ChEBI:CHEBI:57692;
PATHWAY	Amino-acid degradation.
SUBCELLULAR LOCATION	Cell inner membrane.
SIMILARITY	Belongs to the L2HGDH family.

Keywords [?]

Cell inner membrane

Electron transport

Gene Ontology [?]

GO:0016901; Molecular function:oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

GO:0047545; Molecular function:2-hydroxyglutarate dehydrogenase activity

GO:0050660; Molecular function:flavin adenine dinucleotide binding

GO:0019477; Biological process:L-lysine catabolic process

Cross-references [?]

Pfam	PF01266; DAO; 1;

Features [?]

Additional information [?]

Size range	410-450 amino acids
Related rules	None
Fusion	Nter: None Cter: None

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