HAMAP rule MF_00992

General rule information [?]

Accession	MF_00992
Dates	14-FEB-2014 (Created) 1-JUN-2023 (Last updated, Version 15)

Name

MqnC

Scope

Bacteria

Archaea

Templates

Q9K864 (MQNC_HALH5); Q9XAP2 (MQNC_STRCO): [Recover all]

Triggered by

HAMAP; MF_00992 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MQNC

Protein name

RecName:		Full=Cyclic dehypoxanthine futalosine synthase;
		Short=Cyclic DHFL synthase;
		EC 1.21.98.1;
AltName:		Full=Dehypoxanthine futalosine cyclase;
		Short=DHFL cyclase;
AltName:		Full=Menaquinone biosynthetic enzyme MqnC;

Gene name

mqnC

Comments [?]

Function	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
Catalytic activity	RHEA:33083: dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine EC 1.21.98.1

case <FTGroup:1>

Cofactor

[4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

end case

Pathway	Quinol/quinone metabolism; menaquinone biosynthesis.
Similarity	Belongs to the radical SAM superfamily. MqnC family.

Keywords [?]

case <FTGroup:1>

4Fe-4S
Iron
Iron-sulfur
Metal-binding
S-adenosyl-L-methionine

end case

Menaquinone biosynthesis
Oxidoreductase

Gene Ontology [?]

case <FTGroup:1>

GO:0005506; Molecular function: iron ion binding.

end case

GO:0046992; Molecular function: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond.
GO:0009234; Biological process: menaquinone biosynthetic process.

Cross-references [?]

Pfam	PF04055; Radical_SAM; 1;
NCBIfam	TIGR03699; mena_SCO4550; 1;
	TIGR00423; TIGR00423; 1;
PIRSF	PIRSF004762; CHP00423; 1;
PROSITE	PS51918; RADICAL_SAM; 1; trigger=PRU01266;

Features [?]

From: MQNC_HALH5 (Q9K864)

Key From To Description Tag Condition FTGroup

BINDING 64 64 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C 1

BINDING 68 68 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C 1

BINDING 71 71 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet C 1

Additional information [?]

Size range	325-500 amino acids
Related rules	None
Fusion	None

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