HAMAP rule MF_00992
General rule information
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| Accession | MF_00992 |
| Dates | 14-FEB-2014 (Created)
1-JUN-2023 (Last updated, Version 15) |
| Name | MqnC |
| Scope(s) |
Bacteria Archaea |
| Template(s) | Q9K864 (MQNC_HALH5); Q9XAP2 (MQNC_STRCO); [ Recover all ] |
| Triggered by |
HAMAP; MF_00992 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MQNC |
| Protein name | RecName: Full=Cyclic dehypoxanthine futalosine synthase; Short=Cyclic DHFL synthase; EC=1.21.98.1; AltName: Full=Dehypoxanthine futalosine cyclase; Short=DHFL cyclase; AltName: Full=Menaquinone biosynthetic enzyme MqnC; |
| Gene name | Name=mqnC; |
Comments
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| FUNCTION | Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). |
| CATALYTIC ACTIVITY | Reaction=dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'- deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L- methionine; Xref=Rhea:RHEA:33083, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:58864, ChEBI:CHEBI:59789, ChEBI:CHEBI:64270; EC=1.21.98.1; |
| case <FTGroup:1> | |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.; |
| end case | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| SIMILARITY | Belongs to the radical SAM superfamily. MqnC family. |
Keywords
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| case <FTGroup:1> | |
| 4Fe-4S | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| S-adenosyl-L-methionine | |
| end case | |
| Menaquinone biosynthesis | |
| Oxidoreductase | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0005506; Molecular function:iron ion binding | |
| end case | |
| GO:0046992; Molecular function:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
Cross-references
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| Pfam | PF04055; Radical_SAM; 1; |
| NCBIfam | TIGR03699; mena_SCO4550; 1; |
| NCBIfam | TIGR00423; TIGR00423; 1; |
| PIRSF | PIRSF004762; CHP00423; 1; |
| PROSITE | PS51918; RADICAL_SAM; 1; |
Features
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| From: MQNC_HALH5 (Q9K864) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 64 | 64 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 68 | 68 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
| BINDING | 71 | 71 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet" |
C | 1 | |||||||
Additional information
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| Size range | 325-500 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |