HAMAP rule MF_00992
General rule information
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Accession | MF_00992 |
Dates | 14-FEB-2014 (Created) 1-JUN-2023 (Last updated, Version 15) |
Name | MqnC |
Scope | Bacteria
Archaea |
Templates | Q9K864 (MQNC_HALH5); Q9XAP2 (MQNC_STRCO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). |
Catalytic activity | RHEA:33083: dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine
EC 1.21.98.1 |
case <FTGroup:1>
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. |
end case
Pathway | Quinol/quinone metabolism; menaquinone biosynthesis. |
Similarity | Belongs to the radical SAM superfamily. MqnC family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0046992; Molecular function: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond.
GO:0009234; Biological process: menaquinone biosynthetic process.
GO:0009234; Biological process: menaquinone biosynthetic process.
Cross-references
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Pfam | PF04055; Radical_SAM; 1; |
NCBIfam | TIGR03699; mena_SCO4550; 1; |
TIGR00423; TIGR00423; 1; | |
PIRSF | PIRSF004762; CHP00423; 1; |
PROSITE | PS51918; RADICAL_SAM; 1; trigger=PRU01266; |
Features
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From: MQNC_HALH5 (Q9K864) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 64 | 64 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 | |||||||
BINDING | 68 | 68 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 | |||||||
BINDING | 71 | 71 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet | C | 1 |
Additional information
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Size range | 325-500 amino acids |
Related rules | None |
Fusion | None |