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HAMAP rule MF_00992

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General rule information [?]

Accession MF_00992
Dates 14-FEB-2014 (Created)
1-JUN-2023 (Last updated, Version 15)
Name MqnC
Templates Q9K864 (MQNC_HALH5); Q9XAP2 (MQNC_STRCO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cyclic dehypoxanthine futalosine synthase;
Short=Cyclic DHFL synthase;
AltName: Full=Dehypoxanthine futalosine cyclase;
Short=DHFL cyclase;
AltName: Full=Menaquinone biosynthetic enzyme MqnC;
Gene name

Comments [?]

Function Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
Catalytic activity RHEA:33083: dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine
case <FTGroup:1>
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
end case
Pathway Quinol/quinone metabolism; menaquinone biosynthesis.
Similarity Belongs to the radical SAM superfamily. MqnC family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0046992; Molecular function: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond.
GO:0009234; Biological process: menaquinone biosynthetic process.

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
NCBIfam TIGR03699; mena_SCO4550; 1;
TIGR00423; TIGR00423; 1;
PIRSF PIRSF004762; CHP00423; 1;
PROSITE PS51918; RADICAL_SAM; 1; trigger=PRU01266;

Features [?]

From: MQNC_HALH5 (Q9K864)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     64     64       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet     C   1
BINDING     68     68       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet     C   1
BINDING     71     71       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" /ligand_note="4Fe-4S-S-AdoMet     C   1

Additional information [?]

Size range 325-500 amino acids
Related rules None
Fusion None