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HAMAP rule MF_00992

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General rule information [?]

Accession MF_00992
Dates 14-FEB-2014 (Created)
1-JUN-2023 (Last updated, Version 15)
Name MqnC
Scope(s) Bacteria
Archaea
Template(s) Q9K864 (MQNC_HALH5); Q9XAP2 (MQNC_STRCO); [ Recover all ]
Triggered by HAMAP; MF_00992 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MQNC
Protein name RecName: Full=Cyclic dehypoxanthine futalosine synthase;
                 Short=Cyclic DHFL synthase;
                 EC=1.21.98.1;
AltName: Full=Dehypoxanthine futalosine cyclase;
                 Short=DHFL cyclase;
AltName: Full=Menaquinone biosynthetic enzyme MqnC;
Gene name Name=mqnC;

Comments [?]

FUNCTIONRadical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
CATALYTIC ACTIVITY Reaction=dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'- deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L- methionine; Xref=Rhea:RHEA:33083, ChEBI:CHEBI:15378, ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:58864, ChEBI:CHEBI:59789, ChEBI:CHEBI:64270; EC=1.21.98.1;
case <FTGroup:1>
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis.
SIMILARITYBelongs to the radical SAM superfamily. MqnC family.

Keywords [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0046992; Molecular function:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
GO:0009234; Biological process:menaquinone biosynthetic process

Cross-references [?]

Pfam PF04055; Radical_SAM; 1;
NCBIfam TIGR03699; mena_SCO4550; 1;
NCBIfam TIGR00423; TIGR00423; 1;
PIRSF PIRSF004762; CHP00423; 1;
PROSITE PS51918; RADICAL_SAM; 1;

Features [?]

From: MQNC_HALH5 (Q9K864)
Key From To Description Tag Condition FTGroup
BINDING 64 64 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_note="4Fe-4S-S-AdoMet"
C 1
BINDING 68 68 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_note="4Fe-4S-S-AdoMet"
C 1
BINDING 71 71 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"
/ligand_note="4Fe-4S-S-AdoMet"
C 1

Additional information [?]

Size range 325-500 amino acids
Related rules None
Fusion Nter: None Cter: None



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