HAMAP rule MF_00994
General rule information
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Accession | MF_00994 |
Dates | 14-FEB-2014 (Created) 26-JAN-2023 (Last updated, Version 8) |
Name | LPS_assembly_LapB |
Scope | Bacteria; Pseudomonadota |
Template | P0AB58 (LAPB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane. |
Subcellular location | Cell inner membrane; Single-pass membrane protein; Cytoplasmic side. |
Similarity | Belongs to the LapB family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0046890; Biological process: regulation of lipid biosynthetic process.
GO:0009898; Cellular component: cytoplasmic side of plasma membrane.
GO:0009898; Cellular component: cytoplasmic side of plasma membrane.
Cross-references
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PROSITE | PS50005; TPR; 1; |
PS50293; TPR_REGION; 1; | |
Pfam | PF07719; TPR_2; 1; |
PF13176; TPR_7; 1; | |
PF00515; TPR_1; 1; |
Computed features
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REP | Repeat_TPR; TPR; 2-7; trigger=yes; |
Features
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From: LAPB_ECOLI (P0AB58) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TRANSMEM | 1 | 20 | Helical | |||||||||
TOPO_DOM | 21 | Cter | Cytoplasmic | |||||||||
BINDING | 357 | 357 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 | |||||||
BINDING | 360 | 360 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 | |||||||
BINDING | 371 | 371 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 | |||||||
BINDING | 374 | 374 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | C | 1 |
Additional information
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Size range | 350-430 amino acids |
Related rules | None |
Fusion | None |