HAMAP rule MF_00994

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00994
Accession	MF_00994
Dates	14-FEB-2014 (Created) 29-AUG-2025 (Last updated, Version )
Name	LPS_assembly_LapB
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0AB58; [ Recover all ]
Triggered by	HAMAP; MF_00994 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LAPB
Protein name	RecName: Full=Lipopolysaccharide assembly protein B;
Gene name	Name=lapB;

Comments [?]

FUNCTION	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. Regulates the proteolytic activity of FtsH towards LpxC by acting as an adapter protein which interacts with FtsH via its transmembrane helices while its cytoplasmic domain recruits LpxC for degradation by FtsH. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
SUBCELLULAR LOCATION	Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
SIMILARITY	Belongs to the LapB family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0046890; Biological process:regulation of lipid biosynthetic process
GO:0009898; Cellular component:cytoplasmic side of plasma membrane

Cross-references [?]

Features [?]

From: LAPB_ECOLI (P0AB58)

Key

From

Description

Tag

Condition

FTGroup

TRANSMEM

/note="Helical"

TOPO_DOM

Cter

/note="Cytoplasmic"

BINDING

357

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

360

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

371

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

374

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

Additional information [?]