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Annotation rule MF_00994
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General rule information [?]

Accession MF_00994
Dates 14-FEB-2014 (Created)
19-NOV-2019 (Last updated, Version 4)
Name LPS_assembly_LapB
Scope
Bacteria; Proteobacteria
Template P0AB58 (LAPB_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LAPB
Protein name
RecName: Full=Lipopolysaccharide assembly protein B;
Gene name
lapB

Comments [?]

Function Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
Subcellular location Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
Similarity Belongs to the LapB family.

Keywords [?]

Cell inner membrane
Cell membrane
Membrane
Repeat
TPR repeat
Transmembrane
Transmembrane helix
case <FTGroup:1>
Iron
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0046890; Biological process: regulation of lipid biosynthetic process.
GO:0031235; Cellular component: intrinsic component of the cytoplasmic side of the plasma membrane.

Cross-references [?]

PROSITE PS50005; TPR; 1;
PS50293; TPR_REGION; 1;
Pfam PF07719; TPR_2; 1;
PF13176; TPR_7; 1;
PF00515; TPR_1; 1;

Computed features [?]

REP Repeat_TPR; TPR; 2-7; trigger=yes;

Features [?]

From: LAPB_ECOLI (P0AB58)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     1     20       Helical        
TOPO_DOM     21     Cter       Cytoplasmic        
METAL     357     357       Iron     C   1
METAL     360     360       Iron     C   1
METAL     371     371       Iron     C   1
METAL     374     374       Iron     C   1

Additional information [?]

Size range 350-430 amino acids
Related rules None
Fusion None


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