HAMAP rule MF_00994
General rule information
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Accession | MF_00994 |
Dates | 14-FEB-2014 (Created)
26-JAN-2023 (Last updated, Version 8) |
Name | LPS_assembly_LapB |
Scope(s) |
Bacteria Pseudomonadota |
Template(s) | P0AB58 (LAPB_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_00994 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | LAPB |
Protein name | RecName: Full=Lipopolysaccharide assembly protein B; |
Gene name | Name=lapB; |
Comments
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FUNCTION | Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane. |
SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein; Cytoplasmic side. |
SIMILARITY | Belongs to the LapB family. |
Keywords
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Cell inner membrane | |
Cell membrane | |
Membrane | |
Repeat | |
TPR repeat | |
Transmembrane | |
Transmembrane helix | |
case <FTGroup:1> | |
Iron | |
Metal-binding | |
end case |
Gene Ontology
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case <FTGroup:1> | |
GO:0005506; Molecular function:iron ion binding | |
end case | |
GO:0046890; Biological process:regulation of lipid biosynthetic process | |
GO:0009898; Cellular component:cytoplasmic side of plasma membrane |
Cross-references
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PROSITE | PS50005; TPR; 1; |
PROSITE | PS50293; TPR_REGION; 1; |
Pfam | PF07719; TPR_2; 1; |
Pfam | PF13176; TPR_7; 1; |
Pfam | PF00515; TPR_1; 1; |
REP | Repeat_TPR; TPR; 2-7; |
Features
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From: LAPB_ECOLI (P0AB58) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
TRANSMEM | 1 | 20 | /note="Helical" | |||||||||
TOPO_DOM | 21 | Cter | /note="Cytoplasmic" | |||||||||
BINDING | 357 | 357 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
C | 1 | |||||||
BINDING | 360 | 360 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
C | 1 | |||||||
BINDING | 371 | 371 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
C | 1 | |||||||
BINDING | 374 | 374 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
C | 1 |
Additional information
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Size range | 350-430 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |