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HAMAP rule MF_00994

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General rule information [?]

Accession MF_00994
Dates 14-FEB-2014 (Created)
26-JAN-2023 (Last updated, Version 8)
Name LPS_assembly_LapB
Scope(s) Bacteria
Template(s) P0AB58 (LAPB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_00994 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LAPB
Protein name RecName: Full=Lipopolysaccharide assembly protein B;
Gene name Name=lapB;

Comments [?]

FUNCTIONModulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein; Cytoplasmic side.
SIMILARITYBelongs to the LapB family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0046890; Biological process:regulation of lipid biosynthetic process
GO:0009898; Cellular component:cytoplasmic side of plasma membrane

Cross-references [?]

PROSITE PS50005; TPR; 1;
Pfam PF07719; TPR_2; 1;
Pfam PF13176; TPR_7; 1;
Pfam PF00515; TPR_1; 1;
REP Repeat_TPR; TPR; 2-7;

Features [?]

Key From To Description Tag Condition FTGroup
TRANSMEM 1 20 /note="Helical"
TOPO_DOM 21 Cter /note="Cytoplasmic"
BINDING 357 357 /ligand="Fe cation"
C 1
BINDING 360 360 /ligand="Fe cation"
C 1
BINDING 371 371 /ligand="Fe cation"
C 1
BINDING 374 374 /ligand="Fe cation"
C 1

Additional information [?]

Size range 350-430 amino acids
Related rules None
Fusion Nter: None Cter: None

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