HAMAP rule MF_00994

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_00994
Accession	MF_00994
Dates	14-FEB-2014 (Created) 26-JAN-2023 (Last updated, Version 9)
Name	LPS_assembly_LapB
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0AB58; [ Recover all ]
Triggered by	HAMAP; MF_00994 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LAPB
Protein name	RecName: Full=Lipopolysaccharide assembly protein B;
Gene name	Name=lapB;

Comments [?]

FUNCTION	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
SUBCELLULAR LOCATION	Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
SIMILARITY	Belongs to the LapB family.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0046890; Biological process:regulation of lipid biosynthetic process
GO:0009898; Cellular component:cytoplasmic side of plasma membrane

Cross-references [?]

Features [?]

From: LAPB_ECOLI (P0AB58)

Key

From

Description

Tag

Condition

FTGroup

TRANSMEM

/note="Helical"

TOPO_DOM

Cter

/note="Cytoplasmic"

BINDING

357

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

360

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

371

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

BINDING

374

/ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"

Additional information [?]