HAMAP rule MF_00994

General rule information [?]

Accession	MF_00994
Dates	14-FEB-2014 (Created) 26-JAN-2023 (Last updated, Version 8)

Name	LPS_assembly_LapB

Scope

Bacteria; Pseudomonadota

Template

P0AB58 (LAPB_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

LAPB

Protein name

RecName:

Full=Lipopolysaccharide assembly protein B;

Gene name

lapB

Comments [?]

Function	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane.
Subcellular location	Cell inner membrane; Single-pass membrane protein; Cytoplasmic side.
Similarity	Belongs to the LapB family.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

case <FTGroup:1>

GO:0005506; Molecular function: iron ion binding.

end case

GO:0046890; Biological process: regulation of lipid biosynthetic process.
GO:0009898; Cellular component: cytoplasmic side of plasma membrane.

Cross-references [?]

Computed features [?]

REP	Repeat_TPR; TPR; 2-7; trigger=yes;

Features [?]

From: LAPB_ECOLI (P0AB58)

Key From To Description Tag Condition FTGroup

TRANSMEM 1 20 Helical

TOPO_DOM 21 Cter Cytoplasmic

BINDING 357 357 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 C 1

BINDING 360 360 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 C 1

BINDING 371 371 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 C 1

BINDING 374 374 /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 C 1

Additional information [?]