HAMAP logo

HAMAP rule MF_01002

Send feedback

General rule information [?]

Accession MF_01002
Dates 7-FEB-2002 (Created)
3-JUN-2021 (Last updated, Version 31)
Name WecF_RffT
Scope(s) Bacteria
Template(s) P56258 (WECF_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01002 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier WECF
Protein name RecName: Full=TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase;
AltName: Full=4-alpha-L-fucosyltransferase;
AltName: Full=TDP-Fuc4NAc:lipid II Fuc4NAc transferase;
                 Short=Fuc4NAc transferase;
Gene name Name=wecF; Synonyms=rffT;

Comments [?]

FUNCTIONCatalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
CATALYTIC ACTIVITY Reaction=beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis- undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D- galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc- undecaprenyl diphosphate + dTDP + H(+); Xref=Rhea:RHEA:28759, ChEBI:CHEBI:15378, ChEBI:CHEBI:58369, ChEBI:CHEBI:61495, ChEBI:CHEBI:61496, ChEBI:CHEBI:68493; EC=;
PATHWAYBacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein.
SIMILARITYBelongs to the glycosyltransferase 56 family.

Keywords [?]

Gene Ontology [?]

GO:0016758; Molecular function:hexosyltransferase activity
GO:0009246; Biological process:enterobacterial common antigen biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF07429; Glyco_transf_56; 1;

Features [?]

Additional information [?]

Size range 359-361 amino acids
Related rules None
Fusion Nter: None Cter: None

View rule in raw text format (no links)