HAMAP rule MF_01002
General rule information
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Accession | MF_01002 |
Dates | 7-FEB-2002 (Created)
3-JUN-2021 (Last updated, Version 31) |
Name | WecF_RffT |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P56258 (WECF_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01002 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | WECF |
Protein name | RecName: Full=TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase; EC=2.4.1.325; AltName: Full=4-alpha-L-fucosyltransferase; AltName: Full=TDP-Fuc4NAc:lipid II Fuc4NAc transferase; Short=Fuc4NAc transferase; |
Gene name | Name=wecF; Synonyms=rffT; |
Comments
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FUNCTION | Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis. |
CATALYTIC ACTIVITY | Reaction=beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis- undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D- galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc- undecaprenyl diphosphate + dTDP + H(+); Xref=Rhea:RHEA:28759, ChEBI:CHEBI:15378, ChEBI:CHEBI:58369, ChEBI:CHEBI:61495, ChEBI:CHEBI:61496, ChEBI:CHEBI:68493; EC=2.4.1.325; |
PATHWAY | Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis. |
SUBCELLULAR LOCATION | Cell inner membrane; Peripheral membrane protein. |
SIMILARITY | Belongs to the glycosyltransferase 56 family. |
Keywords
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Gene Ontology
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GO:0016758; Molecular function:hexosyltransferase activity |
GO:0009246; Biological process:enterobacterial common antigen biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF07429; Glyco_transf_56; 1; |
Features
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Additional information
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Size range | 359-361 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |