HAMAP rule MF_01002

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01002
Accession	MF_01002
Dates	28-FEB-2005 (Created) 03-JUN-2021 (Last updated, Version 26)
Name	WecF_RffT
Scope(s)	Bacteria Enterobacterales
Template(s)	P56258; [ Recover all ]
Triggered by	HAMAP; MF_01002 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	WECF
Protein name	RecName: Full=TDP-N-acetylfucosamine:lipid II N-acetylfucosaminyltransferase; EC=2.4.1.325; AltName: Full=4-alpha-L-fucosyltransferase; AltName: Full=TDP-Fuc4NAc:lipid II Fuc4NAc transferase; Short=Fuc4NAc transferase;
Gene name	Name=wecF; Synonyms=rffT;

Comments [?]

FUNCTION	Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis.
CATALYTIC ACTIVITY	Reaction=beta-D-ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis- undecaprenyl diphosphate + dTDP-4-acetamido-4,6-dideoxy-alpha-D- galactose = alpha-D-FucNAc4-(1->4)-beta-D-ManNAcA-(1->4)-D-GlcNAc- undecaprenyl diphosphate + dTDP + H(+); Xref=Rhea:RHEA:28759, ChEBI:CHEBI:15378, ChEBI:CHEBI:58369, ChEBI:CHEBI:61495, ChEBI:CHEBI:61496, ChEBI:CHEBI:68493; EC=2.4.1.325;
PATHWAY	Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
SUBCELLULAR LOCATION	Cell inner membrane; Peripheral membrane protein.
SIMILARITY	Belongs to the glycosyltransferase 56 family.

Keywords [?]

Gene Ontology [?]

GO:0016758; Molecular function:hexosyltransferase activity

GO:0009246; Biological process:enterobacterial common antigen biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF07429; Glyco_transf_56; 1;

Features [?]

Additional information [?]