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HAMAP rule MF_01005

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General rule information [?]

Accession MF_01005
Dates 15-FEB-2002 (Created)
19-NOV-2022 (Last updated, Version 41)
Name BtuD
Scope(s) Bacteria
Enterobacterales
Vibrionaceae
Template(s) P06611 (BTUD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01005 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BTUD
Protein name RecName: Full=Vitamin B12 import ATP-binding protein BtuD;
                 EC=7.6.2.8;
AltName: Full=Vitamin B12-transporting ATPase;
Gene name Name=btuD;

Comments [?]

FUNCTIONPart of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
CATALYTIC ACTIVITY Reaction=an R-cob(III)alamin(out) + ATP + H2O = ADP + an R- cob(III)alamin(in) + H(+) + phosphate; Xref=Rhea:RHEA:17873, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:140785, ChEBI:CHEBI:456216; EC=7.6.2.8;
SUBUNITThe complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Peripheral membrane protein.
end case
SIMILARITYBelongs to the ABC transporter superfamily. Vitamin B12 importer (TC 3.A.1.13.1) family.

Keywords [?]

ATP-binding
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Nucleotide-binding
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a>
Transport

Gene Ontology [?]

GO:0015420; Molecular function:ABC-type vitamin B12 transporter activity
GO:0015889; Biological process:cobalamin transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00005; ABC_tran; 1;
PROSITE PS00211; ABC_TRANSPORTER_1; 1;
PROSITE PS50893; ABC_TRANSPORTER_2; 1;

Features [?]

From: BTUD_ECOLI (P06611)
Key From To Description Tag Condition FTGroup
BINDING 33 40 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
G-P-N-G-[ASC]-G-K-S

Additional information [?]

Size range 249-255 amino acids
Related rules None
Fusion Nter: None Cter: None



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