HAMAP rule MF_01006
General rule information
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| Accession | MF_01006 |
| Dates | 1-MAR-2002 (Created)
3-SEP-2024 (Last updated, Version 60) |
| Name | Undec_diphosphatase |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P60932 (UPPP_ECOLI); P60934 (UPPP_STRPN); [ Recover all ] |
| Triggered by |
HAMAP; MF_01006 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | UPPP |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=Undecaprenyl-diphosphatase; EC=3.6.1.27; AltName: Full=Bacitracin resistance protein; AltName: Full=Undecaprenyl pyrophosphate phosphatase; |
| end case | |
| case <OC:Archaea> | |
| Protein name | RecName: Full=Undecaprenyl-diphosphatase; EC=3.6.1.27; AltName: Full=Undecaprenyl pyrophosphate phosphatase; |
| end case | |
| Gene name | Name=uppP; |
Comments
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| case <OC:Bacteria> | |
| FUNCTION | Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin. |
| end case | |
| case <OC:Archaea> | |
| FUNCTION | Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=di-trans,octa-cis-undecaprenyl diphosphate + H2O = di- trans,octa-cis-undecaprenyl phosphate + phosphate + H(+); Xref=Rhea:RHEA:28094, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:58405, ChEBI:CHEBI:60392; EC=3.6.1.27; |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| case <OC:Bacteria> | |
| MISCELLANEOUS | Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. |
| end case | |
| SIMILARITY | Belongs to the UppP family. |
Keywords
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| case <OC:Bacteria> | |
| Antibiotic resistance | |
| Cell shape | |
| Cell wall biogenesis/degradation | |
| end case | |
| Hydrolase | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| case <OC:Bacteria> | |
| Peptidoglycan synthesis | |
| end case | |
| Cell membrane | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0050380; Molecular function:undecaprenyl-diphosphatase activity | |
| case <OCellular component:Bacteria> | |
| GO:0046677; Biological process:response to antibiotic | |
| end case | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF02673; BacA; 1; |
| NCBIfam | TIGR00753; Undec_PP_bacA; 1; |
| General | Transmembrane; -; 5-9; |
Features
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Additional information
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| Size range | 237-343 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | UPPP2 from RHILO is shorter but can not easily be extended. |