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HAMAP rule MF_01006

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General rule information [?]

Accession MF_01006
Dates 1-MAR-2002 (Created)
1-JUN-2023 (Last updated, Version 56)
Name Undec_diphosphatase
Scope
Bacteria
Archaea
Templates P60932 (UPPP_ECOLI); P60934 (UPPP_STRPN): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
UPPP
case <OC:Bacteria>
Protein name
RecName: Full=Undecaprenyl-diphosphatase;
EC 3.6.1.27;
AltName: Full=Bacitracin resistance protein;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
case <OC:Archaea>
Protein name
RecName: Full=Undecaprenyl-diphosphatase;
EC 3.6.1.27;
AltName: Full=Undecaprenyl pyrophosphate phosphatase;
end case
Gene name
uppP

Comments [?]

case <OC:Bacteria>
Function Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
end case
case <OC:Archaea>
Function Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
end case
Catalytic activity RHEA:28094: di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate
EC 3.6.1.27
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
case <OC:Bacteria>
Miscellaneous Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.
end case
Similarity Belongs to the UppP family.

Keywords [?]

case <OC:Bacteria>
Antibiotic resistance
Cell shape
Cell wall biogenesis/degradation
end case
Hydrolase
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <OC:Bacteria>
Peptidoglycan synthesis
end case
Cell membrane
Membrane
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0050380; Molecular function: undecaprenyl-diphosphatase activity.
case <OC:Bacteria>
GO:0046677; Biological process: response to antibiotic.
end case
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02673; BacA; 1;
NCBIfam TIGR00753; Undec_PP_bacA; 1;

Computed features [?]

General Transmembrane; -; 5-9; trigger=yes;

Additional information [?]

Size range 237-343 amino acids
Related rules None
Fusion None
Comments UPPP2 from RHILO is shorter but can not easily be extended.


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