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HAMAP rule MF_01012

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General rule information [?]

Accession MF_01012
Dates 19-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 26)
Name 23SrRNA_methyltr_RlmC
Bacteria; Gammaproteobacteria
Templates P75817 (RLMC_ECOLI); P55135 (RLMD_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
AltName: Full=23S rRNA(m5U747)-methyltransferase;
Gene name

Comments [?]

Function Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
Catalytic activity RHEA:42628: S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0070041; Molecular function: rRNA (uridine-C5-)-methyltransferase activity.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0031167; Biological process: rRNA methylation.

Cross-references [?]

Pfam PF05958; tRNA_U5-meth_tr; 1;
PS01230; TRMA_1; 1;
PS01231; TRMA_2; 1;
NCBIfam TIGR02085; Meth_trns_rumB; 1;

Features [?]

From: RLMC_ECOLI (P75817)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     334     334       Nucleophile     C  
BINDING     3     3       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     11     11       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     14     14       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     87     87       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     212     212       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     Q  
BINDING     241     241       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     F  
BINDING     262     262       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     E  
BINDING     307     307       /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789     N  

Additional information [?]

Size range 375-392 amino acids
Related rules None
Fusion None