Home  |  Contact
Annotation rule MF_01012
Send feedback

General rule information [?]

Accession MF_01012
Dates 19-APR-2002 (Created)
19-NOV-2019 (Last updated, Version 23)
Name 23SrRNA_methyltr_RlmC
Scope
Bacteria; Gammaproteobacteria
Templates P75817 (RLMC_ECOLI); P55135 (RLMD_ECOLI): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RLMC
Protein name
RecName: Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
EC 2.1.1.189;
AltName: Full=23S rRNA(m5U747)-methyltransferase;
Gene name
rlmC

Comments [?]

Function Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
Catalytic activity RHEA:42628: S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.189
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0070041; Molecular function: rRNA (uridine-C5-)-methyltransferase activity.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0031167; Biological process: rRNA methylation.

Cross-references [?]

Pfam PF05958; tRNA_U5-meth_tr; 1;
PROSITE PS51687; SAM_MT_RNA_M5U; 1;
PS01230; TRMA_1; 1;
PS01231; TRMA_2; 1;
TIGRFAMs TIGR02085; Meth_trns_rumB; 1;

Features [?]

From: RLMC_ECOLI (P75817)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     334     334       Nucleophile     C  
METAL     3     3       Iron-sulfur (4Fe-4S)     C   1
METAL     11     11       Iron-sulfur (4Fe-4S)     C   1
METAL     14     14       Iron-sulfur (4Fe-4S)     C   1
METAL     87     87       Iron-sulfur (4Fe-4S)     C   1
BINDING     212     212       S-adenosyl-L-methionine     Q  
BINDING     241     241       S-adenosyl-L-methionine; via carbonyl oxygen     F  
BINDING     262     262       S-adenosyl-L-methionine     E  
BINDING     307     307       S-adenosyl-L-methionine     N  

Additional information [?]

Size range 375-392 amino acids
Related rules None
Fusion None