HAMAP rule MF_01012

General rule information [?]

Accession	MF_01012
Dates	19-APR-2002 (Created) 1-JUN-2023 (Last updated, Version 26)

Name	23SrRNA_methyltr_RlmC

Scope

Bacteria; Gammaproteobacteria

Templates

P75817 (RLMC_ECOLI); P55135 (RLMD_ECOLI): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

RLMC

Protein name

RecName:		Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
		EC 2.1.1.189;
AltName:		Full=23S rRNA(m5U747)-methyltransferase;

Gene name

rlmC

Comments [?]

Function	Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
Catalytic activity	RHEA:42628: S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine EC 2.1.1.189
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Keywords [?]

case <FTGroup:1>

end case

Gene Ontology [?]

GO:0070041; Molecular function: rRNA (uridine-C5-)-methyltransferase activity.

case <FTGroup:1>

GO:0005506; Molecular function: iron ion binding.

end case

GO:0031167; Biological process: rRNA methylation.

Cross-references [?]

Features [?]

From: RLMC_ECOLI (P75817)

Key From To Description Tag Condition FTGroup

ACT_SITE 334 334 Nucleophile C

BINDING 3 3 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 11 11 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 14 14 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 87 87 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 212 212 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 Q

BINDING 241 241 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 F

BINDING 262 262 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 E

BINDING 307 307 /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 N

Additional information [?]