HAMAP rule MF_01012
General rule information
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Accession | MF_01012 |
Dates | 19-APR-2002 (Created) 1-JUN-2023 (Last updated, Version 26) |
Name | 23SrRNA_methyltr_RlmC |
Scope | Bacteria; Gammaproteobacteria |
Templates | P75817 (RLMC_ECOLI); P55135 (RLMD_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA. |
Catalytic activity | RHEA:42628: S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.189 |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0070041; Molecular function: rRNA (uridine-C5-)-methyltransferase activity.
case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0031167; Biological process: rRNA methylation.
Cross-references
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Pfam | PF05958; tRNA_U5-meth_tr; 1; |
PROSITE | PS51687; SAM_MT_RNA_M5U; 1; |
PS01230; TRMA_1; 1; | |
PS01231; TRMA_2; 1; | |
NCBIfam | TIGR02085; Meth_trns_rumB; 1; |
Features
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From: RLMC_ECOLI (P75817) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 334 | 334 | Nucleophile | C | ||||||||
BINDING | 3 | 3 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 11 | 11 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 14 | 14 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 87 | 87 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 212 | 212 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | Q | ||||||||
BINDING | 241 | 241 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | F | ||||||||
BINDING | 262 | 262 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | E | ||||||||
BINDING | 307 | 307 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | N |
Additional information
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Size range | 375-392 amino acids |
Related rules | None |
Fusion | None |