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HAMAP rule MF_01012

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General rule information [?]

Accession MF_01012
Dates 19-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 26)
Name 23SrRNA_methyltr_RlmC
Scope(s) Bacteria
Template(s) P75817 (RLMC_ECOLI); P55135 (RLMD_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01012 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RLMC
Protein name RecName: Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
AltName: Full=23S rRNA(m5U747)-methyltransferase;
Gene name Name=rlmC;

Comments [?]

FUNCTIONCatalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA.
CATALYTIC ACTIVITY Reaction=S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5- methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:42628, Rhea:RHEA-COMP:10154, Rhea:RHEA-COMP:10155, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:65315, ChEBI:CHEBI:74447; EC=;
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily.

Keywords [?]

Gene Ontology [?]

GO:0070041; Molecular function:rRNA (uridine-C5-)-methyltransferase activity
case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0031167; Biological process:rRNA methylation

Cross-references [?]

Pfam PF05958; tRNA_U5-meth_tr; 1;
PROSITE PS01230; TRMA_1; 1;
PROSITE PS01231; TRMA_2; 1;
NCBIfam TIGR02085; Meth_trns_rumB; 1;

Features [?]

From: RLMC_ECOLI (P75817)
Key From To Description Tag Condition FTGroup
ACT_SITE 334 334 /note="Nucleophile" C
BINDING 3 3 /ligand="[4Fe-4S] cluster"
C 1
BINDING 11 11 /ligand="[4Fe-4S] cluster"
C 1
BINDING 14 14 /ligand="[4Fe-4S] cluster"
C 1
BINDING 87 87 /ligand="[4Fe-4S] cluster"
C 1
BINDING 212 212 /ligand="S-adenosyl-L-methionine"
BINDING 241 241 /ligand="S-adenosyl-L-methionine"
BINDING 262 262 /ligand="S-adenosyl-L-methionine"
BINDING 307 307 /ligand="S-adenosyl-L-methionine"

Additional information [?]

Size range 375-392 amino acids
Related rules None
Fusion Nter: None Cter: None

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