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HAMAP rule MF_01013

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General rule information [?]

Accession MF_01013
Dates 22-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 39)
Name HisF
Templates P60664 (HIS6_ECOLI); Q9X0C6 (HIS6_THEMA); Q7SIB9 (HIS6_THET8); Q8ZY16 (HIS6_PYRAE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Imidazole glycerol phosphate synthase subunit HisF;
AltName: Full=IGP synthase cyclase subunit;
AltName: Full=IGP synthase subunit HisF;
AltName: Full=ImGP synthase subunit HisF;
Short=IGPS subunit HisF;
Gene name

Comments [?]

Function IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Catalytic activity RHEA:24793: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Subunit Heterodimer of HisH and HisF.
Subcellular location Cytoplasm.
Similarity Belongs to the HisA/HisF family.

Keywords [?]

Gene Ontology [?]

GO:0000107; Molecular function: imidazoleglycerol-phosphate synthase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00977; His_biosynth; 1;
NCBIfam TIGR00735; HisF; 1;

Features [?]

From: HIS6_THEMA (Q9X0C6)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     11     11             D  
ACT_SITE     130     130             [DE]  

Additional information [?]

Size range 212-281 amino acids
Related rules MF_01014 (HIS4)
Fusion None
Comments First active site problem in LEPBO and in the second copy of CAMJE, LEPIN, PROMM, PSEAE, PARMW and VIBVY; sequences not included in alignment