HAMAP rule MF_01013
General rule information
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| Accession | MF_01013 |
| Dates | 22-APR-2002 (Created)
3-SEP-2024 (Last updated, Version 41) |
| Name | HisF |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P60664 (HIS6_ECOLI); Q9X0C6 (HIS6_THEMA); Q7SIB9 (HIS6_THET8); Q8ZY16 (HIS6_PYRAE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01013 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS6 |
| Protein name | RecName: Full=Imidazole glycerol phosphate synthase subunit HisF; EC=4.3.2.10; AltName: Full=IGP synthase cyclase subunit; AltName: Full=IGP synthase subunit HisF; AltName: Full=ImGP synthase subunit HisF; Short=IGPS subunit HisF; |
| Gene name | Name=hisF; |
Comments
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| FUNCTION | IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. |
| CATALYTIC ACTIVITY | Reaction=5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5- phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D- erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho- beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+); Xref=Rhea:RHEA:24793, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:58278, ChEBI:CHEBI:58359, ChEBI:CHEBI:58475, ChEBI:CHEBI:58525; EC=4.3.2.10; |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. |
| SUBUNIT | Heterodimer of HisH and HisF. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the HisA/HisF family. |
Keywords
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Gene Ontology
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| GO:0000107; Molecular function:imidazoleglycerol-phosphate synthase activity |
| GO:0000105; Biological process:L-histidine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: HIS6_THEMA (Q9X0C6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 11 | 11 | D | |||||||||
| ACT_SITE | 130 | 130 | [DE] | |||||||||
Additional information
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| Size range | 212-281 amino acids |
| Related rules |
MF_01014 |
| Fusion | Nter: None Cter: None |
| Comments | First active site problem in LEPBO and in the second copy of CAMJE, LEPIN, PROMM, PSEAE, PARMW and VIBVY; sequences not included in alignment |