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Annotation rule MF_01013 |
Accession | MF_01013 |
Dates | 22-APR-2002 (Created) 19-NOV-2019 (Last updated, Version 37) |
Name | HisF |
Scope | Bacteria
Archaea |
Templates | P60664 (HIS6_ECOLI); Q9X0C6 (HIS6_THEMA); Q7SIB9 (HIS6_THET8); Q8ZY16 (HIS6_PYRAE): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. |
Catalytic activity | RHEA:24793: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate
EC 4.3.2.10 |
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9. |
Subunit | Heterodimer of HisH and HisF. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the HisA/HisF family. |
From: HIS6_THEMA (Q9X0C6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 11 | 11 | D | |||||||||
ACT_SITE | 130 | 130 | [DE] |
Size range | 212-281 amino acids |
Related rules | MF_01014 (HIS4) |
Fusion | None |
Comments | First active site problem in LEPBO and in the second copy of CAMJE, LEPIN, PROMM, PSEAE, SYNPX and VIBVY; sequences not included in alignment |