HAMAP rule MF_01013

General rule information [?]

Accession	MF_01013
Dates	22-APR-2002 (Created) 1-JUN-2023 (Last updated, Version 39)

Name

HisF

Scope

Bacteria

Archaea

Templates

P60664 (HIS6_ECOLI); Q9X0C6 (HIS6_THEMA); Q7SIB9 (HIS6_THET8); Q8ZY16 (HIS6_PYRAE): [Recover all]

Triggered by

HAMAP; MF_01013 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HIS6

Protein name

RecName:		Full=Imidazole glycerol phosphate synthase subunit HisF;
		EC 4.3.2.10;
AltName:		Full=IGP synthase cyclase subunit;
AltName:		Full=IGP synthase subunit HisF;
AltName:		Full=ImGP synthase subunit HisF;
		Short=IGPS subunit HisF;

Gene name

hisF

Comments [?]

Function	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Catalytic activity	RHEA:24793: 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate EC 4.3.2.10
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
Subunit	Heterodimer of HisH and HisF.
Subcellular location	Cytoplasm.
Similarity	Belongs to the HisA/HisF family.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Histidine biosynthesis
Lyase

Gene Ontology [?]

GO:0000107; Molecular function: imidazoleglycerol-phosphate synthase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00977; His_biosynth; 1;
NCBIfam	TIGR00735; HisF; 1;

Features [?]

From: HIS6_THEMA (Q9X0C6)

Key From To Description Tag Condition FTGroup

ACT_SITE 11 11 D

ACT_SITE 130 130 [DE]

Additional information [?]

Size range	212-281 amino acids
Related rules	MF_01014 (HIS4)
Fusion	None
Comments	First active site problem in LEPBO and in the second copy of CAMJE, LEPIN, PROMM, PSEAE, PARMW and VIBVY; sequences not included in alignment

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