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HAMAP rule MF_01013

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General rule information [?]

Accession MF_01013
Dates 22-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 39)
Name HisF
Scope(s) Bacteria
Template(s) P60664 (HIS6_ECOLI); Q9X0C6 (HIS6_THEMA); Q7SIB9 (HIS6_THET8); Q8ZY16 (HIS6_PYRAE); [ Recover all ]
Triggered by HAMAP; MF_01013 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS6
Protein name RecName: Full=Imidazole glycerol phosphate synthase subunit HisF;
AltName: Full=IGP synthase cyclase subunit;
AltName: Full=IGP synthase subunit HisF;
AltName: Full=ImGP synthase subunit HisF;
                 Short=IGPS subunit HisF;
Gene name Name=hisF;

Comments [?]

FUNCTIONIGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
CATALYTIC ACTIVITY Reaction=5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5- phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5- amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D- erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate; Xref=Rhea:RHEA:24793, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:58278, ChEBI:CHEBI:58359, ChEBI:CHEBI:58475, ChEBI:CHEBI:58525; EC=;
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
SUBUNITHeterodimer of HisH and HisF.
SIMILARITYBelongs to the HisA/HisF family.

Keywords [?]

Gene Ontology [?]

GO:0000107; Molecular function:imidazoleglycerol-phosphate synthase activity
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00977; His_biosynth; 1;
NCBIfam TIGR00735; HisF; 1;

Features [?]

From: HIS6_THEMA (Q9X0C6)
Key From To Description Tag Condition FTGroup
ACT_SITE 11 11 D
ACT_SITE 130 130 [DE]

Additional information [?]

Size range 212-281 amino acids
Related rules MF_01014
Fusion Nter: None Cter: None
Comments First active site problem in LEPBO and in the second copy of CAMJE, LEPIN, PROMM, PSEAE, PARMW and VIBVY; sequences not included in alignment

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