HAMAP rule MF_01018
General rule information
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Accession | MF_01018 |
Dates | 29-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 37) |
Name | HisG_Short |
Scope(s) |
Bacteria Archaea |
Template(s) | Q02129 (HIS1_LACLA); [ Recover all ] |
Triggered by |
HAMAP; MF_01018 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | HIS1 |
Protein name | RecName: Full=ATP phosphoribosyltransferase; Short=ATP-PRT; Short=ATP-PRTase; EC=2.4.2.17; |
Gene name | Name=hisG; |
Comments
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FUNCTION | Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. |
CATALYTIC ACTIVITY | Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=2.4.2.17; |
PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
case <OC:Bacteria> | |
SUBUNIT | Heteromultimer composed of HisG and HisZ subunits. |
end case | |
SUBCELLULAR LOCATION | Cytoplasm. |
case <OC:Bacteria> | |
DOMAIN | Lacks the C-terminal regulatory region which is replaced by HisZ. |
end case | |
SIMILARITY | Belongs to the ATP phosphoribosyltransferase family. Short subfamily. |
Keywords
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Amino-acid biosynthesis |
ATP-binding |
Cytoplasm |
Glycosyltransferase |
Histidine biosynthesis |
Nucleotide-binding |
Transferase |
Gene Ontology
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GO:0003879; Molecular function:ATP phosphoribosyltransferase activity |
GO:0000105; Biological process:histidine biosynthetic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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Additional information
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Size range | 203-241 amino acids |
Related rules |
MF_00079 |
Fusion | Nter: None Cter: None |
Comments | See MF_00079 for the entry relevant to the "long" hisG |