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HAMAP rule MF_01018

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General rule information [?]

Accession MF_01018
Dates 29-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 37)
Name HisG_Short
Scope
Bacteria
Archaea
Template Q02129 (HIS1_LACLA)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS1
Protein name
RecName: Full=ATP phosphoribosyltransferase;
Short=ATP-PRT;
Short=ATP-PRTase;
EC 2.4.2.17;
Gene name
hisG

Comments [?]

Function Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity RHEA:18473: 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
EC 2.4.2.17
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Bacteria>
Subunit Heteromultimer composed of HisG and HisZ subunits.
end case
Subcellular location Cytoplasm.
case <OC:Bacteria>
Domain Lacks the C-terminal regulatory region which is replaced by HisZ.
end case
Similarity Belongs to the ATP phosphoribosyltransferase family. Short subfamily.

Keywords [?]

Amino-acid biosynthesis
ATP-binding
Cytoplasm
Glycosyltransferase
Histidine biosynthesis
Nucleotide-binding
Transferase

Gene Ontology [?]

GO:0003879; Molecular function: ATP phosphoribosyltransferase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01634; HisG; 1;
NCBIfam TIGR00070; HisG; 1;
PROSITE PS01316; ATP_P_PHORIBOSYLTR; 1;

Additional information [?]

Size range 203-241 amino acids
Related rules MF_00079 (HIS1 supersedes the current rule)
Fusion None
Comments See MF_00079 for the entry relevant to the "long" hisG


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