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HAMAP rule MF_01018

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General rule information [?]

Accession MF_01018
Dates 29-APR-2002 (Created)
1-JUN-2023 (Last updated, Version 37)
Name HisG_Short
Scope(s) Bacteria
Template(s) Q02129 (HIS1_LACLA); [ Recover all ]
Triggered by HAMAP; MF_01018 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS1
Protein name RecName: Full=ATP phosphoribosyltransferase;
Gene name Name=hisG;

Comments [?]

FUNCTIONCatalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
CATALYTIC ACTIVITY Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=;
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Bacteria>
SUBUNITHeteromultimer composed of HisG and HisZ subunits.
end case
case <OC:Bacteria>
DOMAINLacks the C-terminal regulatory region which is replaced by HisZ.
end case
SIMILARITYBelongs to the ATP phosphoribosyltransferase family. Short subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003879; Molecular function:ATP phosphoribosyltransferase activity
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01634; HisG; 1;
NCBIfam TIGR00070; HisG; 1;

Features [?]

Additional information [?]

Size range 203-241 amino acids
Related rules MF_00079
Fusion Nter: None Cter: None
Comments See MF_00079 for the entry relevant to the "long" hisG

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