HAMAP rule MF_01018
General rule information
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Accession | MF_01018 |
Dates | 29-APR-2002 (Created) 1-JUN-2023 (Last updated, Version 37) |
Name | HisG_Short |
Scope | Bacteria
Archaea |
Template | Q02129 (HIS1_LACLA) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. |
Catalytic activity | RHEA:18473: 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
EC 2.4.2.17 |
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9. |
case <OC:Bacteria>
Subunit | Heteromultimer composed of HisG and HisZ subunits. |
end case
Subcellular location | Cytoplasm. |
case <OC:Bacteria>
Domain | Lacks the C-terminal regulatory region which is replaced by HisZ. |
end case
Similarity | Belongs to the ATP phosphoribosyltransferase family. Short subfamily. |
Keywords
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Amino-acid biosynthesis
ATP-binding
Cytoplasm
Glycosyltransferase
Histidine biosynthesis
Nucleotide-binding
Transferase
ATP-binding
Cytoplasm
Glycosyltransferase
Histidine biosynthesis
Nucleotide-binding
Transferase
Gene Ontology
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GO:0003879; Molecular function: ATP phosphoribosyltransferase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Additional information
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Size range | 203-241 amino acids |
Related rules | MF_00079 (HIS1 supersedes the current rule) |
Fusion | None |
Comments | See MF_00079 for the entry relevant to the "long" hisG |