HAMAP rule MF_01018

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01018
Accession	MF_01018
Dates	28-FEB-2005 (Created) 28-JUN-2024 (Last updated, Version 29)
Name	HisG_Short
Scope(s)	Bacteria Archaea
Template(s)	Q02129; [ Recover all ]
Triggered by	HAMAP; MF_01018 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	HIS1
Protein name	RecName: Full=ATP phosphoribosyltransferase; Short=ATP-PRT; Short=ATP-PRTase; EC=2.4.2.17;
Gene name	Name=hisG;

Comments [?]

FUNCTION	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
CATALYTIC ACTIVITY	Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho- alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017, ChEBI:CHEBI:73183; EC=2.4.2.17;
PATHWAY	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Bacteria>
SUBUNIT	Heteromultimer composed of HisG and HisZ subunits.
end case
SUBCELLULAR LOCATION	Cytoplasm.
case <OC:Bacteria>
DOMAIN	Lacks the C-terminal regulatory region which is replaced by HisZ.
end case
SIMILARITY	Belongs to the ATP phosphoribosyltransferase family. Short subfamily.

Keywords [?]

Gene Ontology [?]

GO:0003879; Molecular function:ATP phosphoribosyltransferase activity

GO:0000105; Biological process:L-histidine biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]

Size range	203-241 amino acids
Related rules	MF_00079
Fusion	Nter: None Cter: None
Comments	See MF_00079 for the entry relevant to the "long" hisG