HAMAP rule MF_01019
General rule information
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Accession | MF_01019 |
Dates | 28-MAY-2002 (Created) 19-NOV-2019 (Last updated, Version 32) |
Name | HisIE |
Scope | Bacteria
Archaea |
Templates | O82768 (HIS2_ARATH); P06989 (HIS2_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Catalytic activity | RHEA:22828: 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)
EC 3.6.1.31 |
RHEA:20049: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
EC 3.5.4.19 |
|
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. | |
Subcellular location | Cytoplasm. |
Similarity | In the N-terminal section; belongs to the PRA-CH family. |
In the C-terminal section; belongs to the PRA-PH family. |
Keywords
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Amino-acid biosynthesis
ATP-binding
Cytoplasm
Histidine biosynthesis
Hydrolase
Multifunctional enzyme
Nucleotide-binding
ATP-binding
Cytoplasm
Histidine biosynthesis
Hydrolase
Multifunctional enzyme
Nucleotide-binding
Gene Ontology
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GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: HIS2_ECOLI (P06989) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 114 | Phosphoribosyl-AMP cyclohydrolase | |||||||||
REGION | 115 | Cter | Phosphoribosyl-ATP pyrophosphohydrolase |
Additional information
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Size range | 184-300 amino acids |
Related rules | MF_01020 (HIS2); MF_01021 (HIS3) |
Fusion | None |
Comments | See MF_01020 and MF_01021 for the entries relevant to hisI and hisE |