HAMAP rule MF_01019

General rule information [?]

Accession	MF_01019
Dates	28-MAY-2002 (Created) 19-NOV-2019 (Last updated, Version 32)

Name

HisIE

Scope

Bacteria

Archaea

Templates

O82768 (HIS2_ARATH); P06989 (HIS2_ECOLI): [Recover all]

Triggered by

HAMAP; MF_01019 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HIS2

Protein name

RecName:		Full=Histidine biosynthesis bifunctional protein HisIE;
Includes:
	RecName:		Full=Phosphoribosyl-AMP cyclohydrolase;
			Short=PRA-CH;
			EC 3.5.4.19;
Includes:
	RecName:		Full=Phosphoribosyl-ATP pyrophosphatase;
			Short=PRA-PH;
			EC 3.6.1.31;

Gene name

hisI, hisIE

Comments [?]

Catalytic activity	RHEA:22828: 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+) EC 3.6.1.31
	RHEA:20049: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide EC 3.5.4.19
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
Subcellular location	Cytoplasm.
Similarity	In the N-terminal section; belongs to the PRA-CH family.
	In the C-terminal section; belongs to the PRA-PH family.

Keywords [?]

Amino-acid biosynthesis
ATP-binding
Cytoplasm
Histidine biosynthesis
Hydrolase
Multifunctional enzyme
Nucleotide-binding

Gene Ontology [?]

GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01502; PRA-CH; 1;
	PF01503; PRA-PH; 1;

Features [?]

From: HIS2_ECOLI (P06989)

Key From To Description Tag Condition FTGroup

REGION Nter 114 Phosphoribosyl-AMP cyclohydrolase

REGION 115 Cter Phosphoribosyl-ATP pyrophosphohydrolase

Additional information [?]

Size range	184-300 amino acids
Related rules	MF_01020 (HIS2); MF_01021 (HIS3)
Fusion	None
Comments	See MF_01020 and MF_01021 for the entries relevant to hisI and hisE

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