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HAMAP rule MF_01019

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General rule information [?]

Accession MF_01019
Dates 28-MAY-2002 (Created)
19-NOV-2019 (Last updated, Version 32)
Name HisIE
Scope(s) Bacteria
Archaea
Template(s) O82768 (HIS2_ARATH); P06989 (HIS2_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01019 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS2
Protein name RecName: Full=Histidine biosynthesis bifunctional protein HisIE;
                 Includes:
RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
                 Short=PRA-CH;
                 EC=3.5.4.19;
                 Includes:
RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
                 Short=PRA-PH;
                 EC=3.6.1.31;
Gene name Name=hisI; Synonyms=hisIE;

Comments [?]

CATALYTIC ACTIVITY Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D- ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31;
CATALYTIC ACTIVITY Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta- D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide; Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435, ChEBI:CHEBI:59457; EC=3.5.4.19;
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYIn the N-terminal section; belongs to the PRA-CH family.
SIMILARITYIn the C-terminal section; belongs to the PRA-PH family.

Keywords [?]


Gene Ontology [?]

GO:0004635; Molecular function:phosphoribosyl-AMP cyclohydrolase activity
GO:0004636; Molecular function:phosphoribosyl-ATP diphosphatase activity
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01502; PRA-CH; 1;
Pfam PF01503; PRA-PH; 1;

Features [?]

From: HIS2_ECOLI (P06989)
Key From To Description Tag Condition FTGroup
REGION Nter 114 /note="Phosphoribosyl-AMP cyclohydrolase"
REGION 115 Cter /note="Phosphoribosyl-ATP pyrophosphohydrolase"

Additional information [?]

Size range 184-300 amino acids
Related rules MF_01020
MF_01021
Fusion Nter: None Cter: None
Comments See MF_01020 and MF_01021 for the entries relevant to hisI and hisE



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