Home  |  Contact
Annotation rule MF_01019
Send feedback

General rule information [?]

Accession MF_01019
Dates 28-MAY-2002 (Created)
19-NOV-2019 (Last updated, Version 32)
Name HisIE
Scope
Bacteria
Archaea
Templates O82768 (HIS2_ARATH); P06989 (HIS2_ECOLI): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS2
Protein name
RecName: Full=Histidine biosynthesis bifunctional protein HisIE;
Includes:
RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
Short=PRA-CH;
EC 3.5.4.19;
Includes:
RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
Short=PRA-PH;
EC 3.6.1.31;
Gene name
hisI, hisIE

Comments [?]

Catalytic activity RHEA:22828: 1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)
EC 3.6.1.31
RHEA:20049: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
EC 3.5.4.19
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
Subcellular location Cytoplasm.
Similarity In the N-terminal section; belongs to the PRA-CH family.
In the C-terminal section; belongs to the PRA-PH family.

Keywords [?]


Gene Ontology [?]

GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
GO:0004636; Molecular function: phosphoribosyl-ATP diphosphatase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01502; PRA-CH; 1;
PF01503; PRA-PH; 1;

Features [?]

From: HIS2_ECOLI (P06989)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     Nter     114       Phosphoribosyl-AMP cyclohydrolase        
REGION     115     Cter       Phosphoribosyl-ATP pyrophosphohydrolase        

Additional information [?]

Size range 184-300 amino acids
Related rules MF_01020 (HIS2); MF_01021 (HIS3)
Fusion None
Comments See MF_01020 and MF_01021 for the entries relevant to hisI and hisE