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HAMAP rule MF_01020

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General rule information [?]

Accession MF_01020
Dates 24-MAY-2002 (Created)
1-JUN-2023 (Last updated, Version 36)
Name HisE
Scope(s) Bacteria
Template(s) P06989 (HIS2_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01020 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS2
Protein name RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
Gene name Name=hisE;

Comments [?]

CATALYTIC ACTIVITY Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D- ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=;
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
SIMILARITYBelongs to the PRA-PH family.

Keywords [?]

Gene Ontology [?]

GO:0004636; Molecular function:phosphoribosyl-ATP diphosphatase activity
GO:0000105; Biological process:histidine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01503; PRA-PH; 1;
NCBIfam TIGR03188; histidine_hisI; 1;

Features [?]

Additional information [?]

Size range 87-160 amino acids
Related rules MF_01019
Fusion Nter: None Cter: None
Comments See MF_01019 for the entry relevant to the fused hisI-hisE

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