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HAMAP rule MF_01021

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General rule information [?]

Accession MF_01021
Dates 24-MAY-2002 (Created)
19-NOV-2022 (Last updated, Version 38)
Name HisI
Templates O26347 (HIS3_METTH); Q50837 (HIS3_METVA); P06989 (HIS2_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
Gene name

Comments [?]

Function Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Catalytic activity RHEA:20049: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
case <FTGroup:1>
Cofactor Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.
end case
case <FTGroup:2>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the PRA-CH family.

Keywords [?]

case <FTGroup:1>
end case
case <FTGroup:2>
end case
case <FTGroup:1> or <FTGroup:2>
end case

Gene Ontology [?]

GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
case <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF01502; PRA-CH; 1;

Features [?]

From: HIS3_METTH (O26347)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     85     85       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1
BINDING     86     86       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners     C   2
BINDING     87     87       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1
BINDING     89     89       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     D   1
BINDING     102     102       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners     C   2
BINDING     109     109       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners     C   2

Additional information [?]

Size range 101-180 amino acids
Related rules MF_01019 (HIS2 supersedes the current rule)
Fusion None
Comments Possible wrong start in LEPIN and SACS2; not shown in alignment and not taken into account in size range. See MF_01019 for the entry relevant to the fused hisI-hisE.