HAMAP rule MF_01021
General rule information
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| Accession | MF_01021 |
| Dates | 24-MAY-2002 (Created)
19-NOV-2022 (Last updated, Version 38) |
| Name | HisI |
| Scope(s) |
Bacteria Archaea |
| Template(s) | O26347 (HIS3_METTH); Q50837 (HIS3_METVA); P06989 (HIS2_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01021 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS3 |
| Protein name | RecName: Full=Phosphoribosyl-AMP cyclohydrolase; Short=PRA-CH; EC=3.5.4.19; |
| Gene name | Name=hisI; |
Comments
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| FUNCTION | Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. |
| CATALYTIC ACTIVITY | Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta- D-ribosyl)-5-[(5-phospho-beta-D- ribosylamino)methylideneamino]imidazole-4-carboxamide; Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435, ChEBI:CHEBI:59457; EC=3.5.4.19; |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 1 Mg(2+) ion per subunit.; |
| end case | |
| case <FTGroup:2> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the PRA-CH family. |
Keywords
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| Amino-acid biosynthesis | |
| Cytoplasm | |
| Histidine biosynthesis | |
| Hydrolase | |
| case <FTGroup:1> | |
| Magnesium | |
| end case | |
| case <FTGroup:2> | |
| Zinc | |
| end case | |
| case <FTGroup:1> or <FTGroup:2> | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0004635; Molecular function:phosphoribosyl-AMP cyclohydrolase activity | |
| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| case <FTGroup:2> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| GO:0000105; Biological process:histidine biosynthetic process | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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| Pfam | PF01502; PRA-CH; 1; |
Features
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| From: HIS3_METTH (O26347) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 85 | 85 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 86 | 86 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners" |
C | 2 | |||||||
| BINDING | 87 | 87 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | 1 | |||||||
| BINDING | 102 | 102 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners" |
C | 2 | |||||||
| BINDING | 109 | 109 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners" |
C | 2 | |||||||
Additional information
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| Size range | 101-180 amino acids |
| Related rules |
MF_01019 |
| Fusion | Nter: None Cter: None |
| Comments | Possible wrong start in LEPIN and SACS2; not shown in alignment and not taken into account in size range. See MF_01019 for the entry relevant to the fused hisI-hisE. |