HAMAP rule MF_01021

General rule information [?]

Accession	MF_01021
Dates	24-MAY-2002 (Created) 19-NOV-2022 (Last updated, Version 38)

Name

HisI

Scope

Bacteria

Archaea

Templates

O26347 (HIS3_METTH); Q50837 (HIS3_METVA); P06989 (HIS2_ECOLI): [Recover all]

Triggered by

HAMAP; MF_01021 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

HIS3

Protein name

RecName:		Full=Phosphoribosyl-AMP cyclohydrolase;
		Short=PRA-CH;
		EC 3.5.4.19;

Gene name

hisI

Comments [?]

Function	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Catalytic activity	RHEA:20049: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide EC 3.5.4.19

case <FTGroup:1>

Cofactor

Mg(2+)
Note: Binds 1 Mg(2+) ion per subunit.

end case

case <FTGroup:2>

Cofactor

Zn(2+)
Note: Binds 1 zinc ion per subunit.

end case

Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the PRA-CH family.

Keywords [?]

Amino-acid biosynthesis
Cytoplasm
Histidine biosynthesis
Hydrolase

case <FTGroup:1>

Magnesium

end case

case <FTGroup:2>

Zinc

end case

case <FTGroup:1> or <FTGroup:2>

Metal-binding

end case

Gene Ontology [?]

GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.

case <FTGroup:1>

GO:0000287; Molecular function: magnesium ion binding.

end case

case <FTGroup:2>

GO:0008270; Molecular function: zinc ion binding.

end case

GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01502; PRA-CH; 1;

Features [?]

From: HIS3_METTH (O26347)

Key From To Description Tag Condition FTGroup

BINDING 85 85 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D 1

BINDING 86 86 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners C 2

BINDING 87 87 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D 1

BINDING 89 89 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D 1

BINDING 102 102 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners C 2

BINDING 109 109 /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners C 2

Additional information [?]

Size range	101-180 amino acids
Related rules	MF_01019 (HIS2 supersedes the current rule)
Fusion	None
Comments	Possible wrong start in LEPIN and SACS2; not shown in alignment and not taken into account in size range. See MF_01019 for the entry relevant to the fused hisI-hisE.

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