HAMAP rule MF_01021
General rule information
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Accession | MF_01021 |
Dates | 24-MAY-2002 (Created) 19-NOV-2022 (Last updated, Version 38) |
Name | HisI |
Scope | Bacteria
Archaea |
Templates | O26347 (HIS3_METTH); Q50837 (HIS3_METVA); P06989 (HIS2_ECOLI): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
Gene name |
|
Comments
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Function | Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. |
Catalytic activity | RHEA:20049: 1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide
EC 3.5.4.19 |
case <FTGroup:1>
Cofactor | Mg(2+) Note: Binds 1 Mg(2+) ion per subunit. |
end case
case <FTGroup:2>
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9. |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the PRA-CH family. |
Keywords
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case <FTGroup:1>
end case
case <FTGroup:2>
end case
case <FTGroup:1> or <FTGroup:2>
end case
Gene Ontology
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GO:0004635; Molecular function: phosphoribosyl-AMP cyclohydrolase activity.
case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
case <FTGroup:2>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0000105; Biological process: histidine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Pfam | PF01502; PRA-CH; 1; |
Features
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From: HIS3_METTH (O26347) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 85 | 85 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING | 86 | 86 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners | C | 2 | |||||||
BINDING | 87 | 87 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING | 89 | 89 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | D | 1 | |||||||
BINDING | 102 | 102 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners | C | 2 | |||||||
BINDING | 109 | 109 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="ligand shared between dimeric partners | C | 2 |
Additional information
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Size range | 101-180 amino acids |
Related rules | MF_01019 (HIS2 supersedes the current rule) |
Fusion | None |
Comments | Possible wrong start in LEPIN and SACS2; not shown in alignment and not taken into account in size range. See MF_01019 for the entry relevant to the fused hisI-hisE. |