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HAMAP rule MF_01023

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General rule information [?]

Accession MF_01023
Dates 27-JUN-2002 (Created)
1-JUN-2023 (Last updated, Version 45)
Name HisC_aminotrans_2
Scope(s) Bacteria
Archaea
Template(s) P06986 (HIS8_ECOLI); Q9X0D0 (HIS8_THEMA); [ Recover all ]
Triggered by HAMAP; MF_01023 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HIS8
Protein name RecName: Full=Histidinol-phosphate aminotransferase;
                 EC=2.6.1.9;
AltName: Full=Imidazole acetol-phosphate transaminase;
Gene name Name=hisC;

Comments [?]

CATALYTIC ACTIVITY Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766, ChEBI:CHEBI:57980; EC=2.6.1.9;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.
case <OC:Bacteria>
SUBUNITHomodimer.
end case
SIMILARITYBelongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004400; Molecular function:histidinol-phosphate transaminase activity
GO:0000105; Biological process:histidine biosynthetic process

Cross-references [?]

Pfam PF00155; Aminotran_1_2; 1;
NCBIfam TIGR01141; HisC; 1;
PROSITE PS00599; AA_TRANSFER_CLASS_2; 1;

Features [?]

From: HIS8_ECOLI (P06986)
Key From To Description Tag Condition FTGroup
MOD_RES 214 214 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 335-401 amino acids
Related rules MF_01513
Fusion Nter: MF_01024 (hisD) Cter: None
Comments Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown in alignment and not taken into account in size range. Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent aminotransferases. PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not have such a fusion, this could be a sequencing artefact.



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