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Annotation rule MF_01023 |
Accession | MF_01023 |
Dates | 27-JUN-2002 (Created) 19-NOV-2019 (Last updated, Version 44) |
Name | HisC_aminotrans_2 |
Scope | Bacteria
Archaea |
Templates | P06986 (HIS8_ECOLI); Q9X0D0 (HIS8_THEMA): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Catalytic activity | RHEA:23744: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
EC 2.6.1.9 |
Cofactor | pyridoxal 5'-phosphate |
Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. |
Subunit | Homodimer. |
Similarity | Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. |
Pfam | PF00155; Aminotran_1_2; 1; |
TIGRFAMs | TIGR01141; HisC; 1; |
PROSITE | PS00599; AA_TRANSFER_CLASS_2; 1; |
From: HIS8_ECOLI (P06986) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
MOD_RES | 214 | 214 | N6-(pyridoxal phosphate)lysine | K |
Size range | 335-401 amino acids |
Related rules | MF_01513 (PATR supersedes the current rule) |
Fusion | Nter: MF_01024 (hisD); Cter: None |
Comments | Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown in alignment and not taken into account in size range. Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent aminotransferases. PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not have such a fusion, this could be a sequencing artefact. |