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Annotation rule MF_01023
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General rule information [?]

Accession MF_01023
Dates 27-JUN-2002 (Created)
19-NOV-2019 (Last updated, Version 44)
Name HisC_aminotrans_2
Scope
Bacteria
Archaea
Templates P06986 (HIS8_ECOLI); Q9X0D0 (HIS8_THEMA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HIS8
Protein name
RecName: Full=Histidinol-phosphate aminotransferase;
EC 2.6.1.9;
AltName: Full=Imidazole acetol-phosphate transaminase;
Gene name
hisC

Comments [?]

Catalytic activity RHEA:23744: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
EC 2.6.1.9
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.
case <OC:Bacteria>
Subunit Homodimer.
end case
Similarity Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004400; Molecular function: histidinol-phosphate transaminase activity.
GO:0000105; Biological process: histidine biosynthetic process.

Cross-references [?]

Pfam PF00155; Aminotran_1_2; 1;
TIGRFAMs TIGR01141; HisC; 1;
PROSITE PS00599; AA_TRANSFER_CLASS_2; 1;

Features [?]

From: HIS8_ECOLI (P06986)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     214     214       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 335-401 amino acids
Related rules MF_01513 (PATR supersedes the current rule)
Fusion Nter: MF_01024 (hisD); Cter: None
Comments Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown in alignment and not taken into account in size range. Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent aminotransferases. PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not have such a fusion, this could be a sequencing artefact.