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HAMAP rule MF_01023
General rule information
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| Accession | MF_01023 |
| Dates | 27-JUN-2002 (Created)
28-JUN-2024 (Last updated, Version 47) |
| Name | HisC_aminotrans_2 |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P06986 (HIS8_ECOLI); Q9X0D0 (HIS8_THEMA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01023 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HIS8 |
| Protein name | RecName: Full=Histidinol-phosphate aminotransferase; EC=2.6.1.9; AltName: Full=Imidazole acetol-phosphate transaminase; |
| Gene name | Name=hisC; |
Comments
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| CATALYTIC ACTIVITY | Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766, ChEBI:CHEBI:57980; EC=2.6.1.9; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. |
| case <OC:Bacteria> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. |
Keywords
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Gene Ontology
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| GO:0004400; Molecular function:histidinol-phosphate transaminase activity |
| GO:0000105; Biological process:L-histidine biosynthetic process |
Cross-references
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| Pfam | PF00155; Aminotran_1_2; 1; |
| NCBIfam | TIGR01141; HisC; 1; |
| PROSITE | PS00599; AA_TRANSFER_CLASS_2; 1; |
Features
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| From: HIS8_ECOLI (P06986) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 214 | 214 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 335-401 amino acids |
| Related rules |
MF_01513 |
| Fusion | Nter: MF_01024 (hisD) Cter: None |
| Comments | Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown in alignment and not taken into account in size range. Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent aminotransferases. PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not have such a fusion, this could be a sequencing artefact. |