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| Annotation rule MF_01023 |
General rule information
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| Accession | MF_01023 |
| Dates | 27-JUN-2002 (Created) 19-NOV-2019 (Last updated, Version 44) |
| Name | HisC_aminotrans_2 |
| Scope | Bacteria
Archaea |
| Templates | P06986 (HIS8_ECOLI); Q9X0D0 (HIS8_THEMA): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Catalytic activity | RHEA:23744: 2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
EC 2.6.1.9 |
| Cofactor | pyridoxal 5'-phosphate |
| Pathway | Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. |
case <OC:Bacteria>
| Subunit | Homodimer. |
end case
| Similarity | Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. |
Keywords
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Gene Ontology
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GO:0004400; Molecular function: histidinol-phosphate transaminase activity.
GO:0000105; Biological process: histidine biosynthetic process.
GO:0000105; Biological process: histidine biosynthetic process.
Cross-references
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| Pfam | PF00155; Aminotran_1_2; 1; |
| TIGRFAMs | TIGR01141; HisC; 1; |
| PROSITE | PS00599; AA_TRANSFER_CLASS_2; 1; |
Features
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| From: HIS8_ECOLI (P06986) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 214 | 214 | N6-(pyridoxal phosphate)lysine | K | ||||||||
Additional information
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| Size range | 335-401 amino acids |
| Related rules | MF_01513 (PATR supersedes the current rule) |
| Fusion | Nter: MF_01024 (hisD); Cter: None |
| Comments | Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown in alignment and not taken into account in size range. Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent aminotransferases. PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not have such a fusion, this could be a sequencing artefact. |