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Annotation rule MF_01024
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General rule information [?]

Accession MF_01024
Dates 20-MAR-2003 (Created)
19-NOV-2019 (Last updated, Version 35)
Name HisD
Scope
Bacteria
Archaea
Templates P06988 (HISX_ECOLI); P10370 (HISX_SALTY): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HISX
Protein name
RecName: Full=Histidinol dehydrogenase;
Short=HDH;
EC 1.1.1.23;
Gene name
hisD

Comments [?]

Function Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
Catalytic activity RHEA:20641: H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH
EC 1.1.1.23
case <FTGroup:1>
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
end case
Pathway Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.
case <OC:Enterobacterales>
Subunit Homodimer.
end case
Similarity Belongs to the histidinol dehydrogenase family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0004399; Molecular function: histidinol dehydrogenase activity.
case <FTGroup:1>
GO:0008270; Molecular function: zinc ion binding.
end case
GO:0000105; Biological process: histidine biosynthetic process.

Cross-references [?]

Pfam PF00815; Histidinol_dh; 1;
PRINTS PR00083; HOLDHDRGNASE; 1;
TIGRFAMs TIGR00069; HisD; 1;
PROSITE PS00611; HISOL_DEHYDROGENASE; 1;

Features [?]

From: HISX_ECOLI (P06988)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     326     326       Proton acceptor     E  
ACT_SITE     327     327       Proton acceptor     H  
METAL     259     259       Zinc     [EQ]   1
METAL     262     262       Zinc     H   1
METAL     360     360       Zinc     D   1
METAL     419     419       Zinc     H   1
BINDING     130     130       NAD     Y   2
BINDING     188     188       NAD     Q   2
BINDING     211     211       NAD     N   2
BINDING     237     237       Substrate     [ST]   3
BINDING     259     259       Substrate     Q   3
BINDING     262     262       Substrate     H   3
BINDING     327     327       Substrate     H   3
BINDING     360     360       Substrate     D   3
BINDING     414     414       Substrate     E   3
BINDING     419     419       Substrate     H   3

Additional information [?]

Size range 368-480 amino acids
Related rules None
Fusion Nter: None; Cter: MF_01023 (hisC)
Comments PHOLL is a fusion between hisC and hisD. As other Enterobacterales do not have such a fusion, this could be a sequencing artefact.