 |
|
Annotation rule MF_01024 |
General rule information
[?]
Accession |
MF_01024 |
Dates |
20-MAR-2003 (Created) 19-NOV-2019 (Last updated, Version 35) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=Histidinol dehydrogenase;
|
|
Short=HDH;
|
|
EC 1.1.1.23;
|
|
Function |
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. |
Catalytic activity |
RHEA:20641: H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH
EC 1.1.1.23
|
case <FTGroup:1>
Cofactor |
Zn(2+) Note: Binds 1 zinc ion per subunit. |
end case
Pathway |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. |
case <OC:Enterobacterales>
end case
Similarity |
Belongs to the histidinol dehydrogenase family. |
case <FTGroup:1>
end case
GO:0004399; Molecular function: histidinol dehydrogenase activity.
case <FTGroup:1>
end case
GO:0000105; Biological process: histidine biosynthetic process.
From: HISX_ECOLI (P06988) |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
ACT_SITE
|
|
326
|
|
326
|
|
Proton acceptor
|
|
|
|
E
|
|
|
ACT_SITE
|
|
327
|
|
327
|
|
Proton acceptor
|
|
|
|
H
|
|
|
METAL
|
|
259
|
|
259
|
|
Zinc
|
|
|
|
[EQ]
|
|
1
|
METAL
|
|
262
|
|
262
|
|
Zinc
|
|
|
|
H
|
|
1
|
METAL
|
|
360
|
|
360
|
|
Zinc
|
|
|
|
D
|
|
1
|
METAL
|
|
419
|
|
419
|
|
Zinc
|
|
|
|
H
|
|
1
|
BINDING
|
|
130
|
|
130
|
|
NAD
|
|
|
|
Y
|
|
2
|
BINDING
|
|
188
|
|
188
|
|
NAD
|
|
|
|
Q
|
|
2
|
BINDING
|
|
211
|
|
211
|
|
NAD
|
|
|
|
N
|
|
2
|
BINDING
|
|
237
|
|
237
|
|
Substrate
|
|
|
|
[ST]
|
|
3
|
BINDING
|
|
259
|
|
259
|
|
Substrate
|
|
|
|
Q
|
|
3
|
BINDING
|
|
262
|
|
262
|
|
Substrate
|
|
|
|
H
|
|
3
|
BINDING
|
|
327
|
|
327
|
|
Substrate
|
|
|
|
H
|
|
3
|
BINDING
|
|
360
|
|
360
|
|
Substrate
|
|
|
|
D
|
|
3
|
BINDING
|
|
414
|
|
414
|
|
Substrate
|
|
|
|
E
|
|
3
|
BINDING
|
|
419
|
|
419
|
|
Substrate
|
|
|
|
H
|
|
3
|
Additional information
[?]
Size range |
368-480 amino acids |
Related rules |
None |
Fusion |
Nter: None; Cter: MF_01023 (hisC) |
Comments |
PHOLL is a fusion between hisC and hisD. As other Enterobacterales do not have such a fusion, this could be a sequencing artefact. |