HAMAP rule MF_01026
General rule information
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| Accession | MF_01026 |
| Dates | 17-JUL-2002 (Created)
1-JUN-2023 (Last updated, Version 45) |
| Name | LeuC_type1 |
| Scope(s) |
Bacteria Archaea Halobacteria |
| Template(s) | P0A6A6 (LEUC_ECOLI); P15717 (LEUC1_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01026 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LEUC |
| Protein name | RecName: Full=3-isopropylmalate dehydratase large subunit; EC=4.2.1.33; AltName: Full=Alpha-IPM isomerase; Short=IPMI; AltName: Full=Isopropylmalate isomerase; |
| Gene name | Name=leuC; |
Comments
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| FUNCTION | Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. |
| CATALYTIC ACTIVITY | Reaction=(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate; Xref=Rhea:RHEA:32287, ChEBI:CHEBI:1178, ChEBI:CHEBI:35121; EC=4.2.1.33; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit.; |
| PATHWAY | Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. |
| SUBUNIT | Heterodimer of LeuC and LeuD. |
| SIMILARITY | Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. |
Keywords
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| Amino-acid biosynthesis |
| Branched-chain amino acid biosynthesis |
| Leucine biosynthesis |
| Lyase |
| Metal-binding |
| Iron |
| Iron-sulfur |
| 4Fe-4S |
Gene Ontology
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| GO:0003861; Molecular function:3-isopropylmalate dehydratase activity |
| GO:0009098; Biological process:leucine biosynthetic process |
Cross-references
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| Pfam | PF00330; Aconitase; 1; |
| PRINTS | PR00415; ACONITASE; 1; |
| NCBIfam | TIGR00170; LeuC; 1; |
| PROSITE | PS00450; ACONITASE_1; 1; |
| PROSITE | PS01244; ACONITASE_2; 1; |
Features
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| From: LEUC_ECOLI (P0A6A6) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 347 | 347 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 407 | 407 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
| BINDING | 410 | 410 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | ||||||||
Additional information
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| Size range | 455-486 amino acids |
| Related rules |
MF_01027 |
| Fusion | Nter: None Cter: None |