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Annotation rule MF_01026
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General rule information [?]

Accession MF_01026
Dates 17-JUL-2002 (Created)
19-NOV-2019 (Last updated, Version 42)
Name LeuC_type1
Scope
Bacteria
Archaea; Halobacteria
Templates P0A6A6 (LEUC_ECOLI); P15717 (LEUC1_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LEUC
Protein name
RecName: Full=3-isopropylmalate dehydratase large subunit;
EC 4.2.1.33;
AltName: Full=Alpha-IPM isomerase;
Short=IPMI;
AltName: Full=Isopropylmalate isomerase;
Gene name
leuC

Comments [?]

Function Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Catalytic activity RHEA:32287: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
EC 4.2.1.33
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.
Subunit Heterodimer of LeuC and LeuD.
Similarity Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.

Keywords [?]

Amino-acid biosynthesis
Branched-chain amino acid biosynthesis
Leucine biosynthesis
Lyase
Metal-binding
Iron
Iron-sulfur
4Fe-4S

Gene Ontology [?]

GO:0003861; Molecular function: 3-isopropylmalate dehydratase activity.
GO:0009098; Biological process: leucine biosynthetic process.

Cross-references [?]

Pfam PF00330; Aconitase; 1;
PRINTS PR00415; ACONITASE; 1;
TIGRFAMs TIGR00170; LeuC; 1;
PROSITE PS00450; ACONITASE_1; 1;
PS01244; ACONITASE_2; 1;

Features [?]

From: LEUC_ECOLI (P0A6A6)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     347     347       Iron-sulfur (4Fe-4S)     C  
METAL     407     407       Iron-sulfur (4Fe-4S)     C  
METAL     410     410       Iron-sulfur (4Fe-4S)     C  

Additional information [?]

Size range 455-486 amino acids
Related rules MF_01027 (LEUC)
Fusion None


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