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Annotation rule MF_01026 |
Accession | MF_01026 |
Dates | 17-JUL-2002 (Created) 19-NOV-2019 (Last updated, Version 42) |
Name | LeuC_type1 |
Scope | Bacteria
Archaea; Halobacteria |
Templates | P0A6A6 (LEUC_ECOLI); P15717 (LEUC1_SALTY): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. |
Catalytic activity | RHEA:32287: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate
EC 4.2.1.33 |
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. |
Pathway | Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. |
Subunit | Heterodimer of LeuC and LeuD. |
Similarity | Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily. |
Pfam | PF00330; Aconitase; 1; |
PRINTS | PR00415; ACONITASE; 1; |
TIGRFAMs | TIGR00170; LeuC; 1; |
PROSITE | PS00450; ACONITASE_1; 1; |
PS01244; ACONITASE_2; 1; |
From: LEUC_ECOLI (P0A6A6) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
METAL | 347 | 347 | Iron-sulfur (4Fe-4S) | C | ||||||||
METAL | 407 | 407 | Iron-sulfur (4Fe-4S) | C | ||||||||
METAL | 410 | 410 | Iron-sulfur (4Fe-4S) | C |
Size range | 455-486 amino acids |
Related rules | MF_01027 (LEUC) |
Fusion | None |