HAMAP rule MF_01031
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_01031 |
| Accession | MF_01031 |
| Dates | 28-FEB-2005 (Created)
25-APR-2024 (Last updated, Version 23) |
| Name | LeuD_type1 |
| Scope(s) |
Bacteria |
| Template(s) | P04787; [ Recover all ] |
| Triggered by |
HAMAP; MF_01031 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | LEUD |
| Protein name | RecName: Full=3-isopropylmalate dehydratase small subunit; EC=4.2.1.33; AltName: Full=Alpha-IPM isomerase; Short=IPMI; AltName: Full=Isopropylmalate isomerase; |
| Gene name | Name=leuD; |
Comments
[?]
| FUNCTION | Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. |
| CATALYTIC ACTIVITY | Reaction=(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate; Xref=Rhea:RHEA:32287, ChEBI:CHEBI:1178, ChEBI:CHEBI:35121; EC=4.2.1.33; |
| PATHWAY | Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. |
| SUBUNIT | Heterodimer of LeuC and LeuD. |
| SIMILARITY | Belongs to the LeuD family. LeuD type 1 subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0003861; Molecular function:3-isopropylmalate dehydratase activity |
| GO:0009098; Biological process:L-leucine biosynthetic process |
Cross-references
[?]
Features
[?]
Additional information
[?]
| Size range | 189-230 amino acids |
| Related rules |
MF_01032 |
| Fusion | Nter: None Cter: None |