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HAMAP rule MF_01039

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General rule information [?]

Accession MF_01039
Dates 12-DEC-2002 (Created)
1-JUN-2023 (Last updated, Version 41)
Name PGAM_GpmA
Scope(s) Bacteria
Template(s) P62707 (GPMA_ECOLI); Q3JWH7 (GPMA_BURP1); P9WIC9 (GPMA_MYCTU); [ Recover all ]
Triggered by HAMAP; MF_01039 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GPMA
Protein name RecName: Full=2,3-bisphosphoglycerate-dependent phosphoglycerate mutase;
                 Short=BPG-dependent PGAM;
Gene name Name=gpmA;

Comments [?]

FUNCTIONCatalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
CATALYTIC ACTIVITY Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate; Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289; EC=;
PATHWAYCarbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 3/5.
case <OC:Pseudomonadota>
end case
SIMILARITYBelongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.

Keywords [?]

Gene Ontology [?]

GO:0046538; Molecular function:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0006094; Biological process:gluconeogenesis
GO:0006096; Biological process:glycolytic process

Cross-references [?]

Pfam PF00300; His_Phos_1; 1;
NCBIfam TIGR01258; pgm_1; 1;

Features [?]

From: GPMA_ECOLI (P62707)
Key From To Description Tag Condition FTGroup
BINDING 10 17 /ligand="substrate" R-H-G-x-S-x(2)-[NK]
BINDING 23 24 /ligand="substrate" [TS]-G
BINDING 89 92 /ligand="substrate" E-[RK]-x-Y
BINDING 116 117 /ligand="substrate" R-R
BINDING 185 186 /ligand="substrate" G-N
ACT_SITE 11 11 /note="Tele-phosphohistidine intermediate" H
ACT_SITE 89 89 /note="Proton donor/acceptor" E
BINDING 62 62 /ligand="substrate" R
BINDING 100 100 /ligand="substrate" K
SITE 184 184 /note="Transition state stabilizer" H

Additional information [?]

Size range 195-400 amino acids
Related rules MF_01040
Fusion Nter: None Cter: None

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