HAMAP rule MF_01039

General rule information [?]

Accession	MF_01039
Dates	12-DEC-2002 (Created) 1-JUN-2023 (Last updated, Version 41)

Name

PGAM_GpmA

Scope

Bacteria

Archaea

Templates

P62707 (GPMA_ECOLI); Q3JWH7 (GPMA_BURP1); P9WIC9 (GPMA_MYCTU): [Recover all]

Triggered by

HAMAP; MF_01039 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GPMA

Protein name

RecName:		Full=2,3-bisphosphoglycerate-dependent phosphoglycerate mutase;
		Short=BPG-dependent PGAM;
		Short=PGAM;
		Short=Phosphoglyceromutase;
		Short=dPGM;
		EC 5.4.2.11;

Gene name

gpmA

Comments [?]

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Catalytic activity	RHEA:15901: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate EC 5.4.2.11
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.

case <OC:Pseudomonadota>

Subunit

Homodimer.

end case

Similarity

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Keywords [?]

Isomerase
Glycolysis
Gluconeogenesis

Gene Ontology [?]

GO:0046538; Molecular function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolytic process.

Cross-references [?]

Pfam	PF00300; His_Phos_1; 1;
NCBIfam	TIGR01258; pgm_1; 1;
PROSITE	PS00175; PG_MUTASE; 1;

Features [?]

From: GPMA_ECOLI (P62707)

Key From To Description Tag Condition FTGroup

BINDING (Optional) 10 17 /ligand="substrate R-H-G-x-S-x(2)-[NK]

BINDING (Optional) 23 24 /ligand="substrate [TS]-G

BINDING (Optional) 89 92 /ligand="substrate E-[RK]-x-Y

BINDING (Optional) 116 117 /ligand="substrate R-R

BINDING (Optional) 185 186 /ligand="substrate G-N

ACT_SITE 11 11 Tele-phosphohistidine intermediate H

ACT_SITE 89 89 Proton donor/acceptor E

BINDING (Optional) 62 62 /ligand="substrate R

BINDING (Optional) 100 100 /ligand="substrate K

SITE 184 184 Transition state stabilizer H

Additional information [?]

Size range	195-400 amino acids
Related rules	MF_01040 (GPMB)
Fusion	None

View rule in raw text format (no links)