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Annotation rule MF_01039
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General rule information [?]

Accession MF_01039
Dates 12-DEC-2002 (Created)
19-NOV-2019 (Last updated, Version 36)
Name PGAM_GpmA
Scope
Bacteria
Archaea
Templates P62707 (GPMA_ECOLI); Q3JWH7 (GPMA_BURP1); P9WIC9 (GPMA_MYCTU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GPMA
Protein name
RecName: Full=2,3-bisphosphoglycerate-dependent phosphoglycerate mutase;
Short=BPG-dependent PGAM;
Short=PGAM;
Short=Phosphoglyceromutase;
Short=dPGM;
EC 5.4.2.11;
Gene name
gpmA

Comments [?]

Function Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Catalytic activity RHEA:15901: (2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate
EC 5.4.2.11
Pathway Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.
case <OC:Proteobacteria>
Subunit Homodimer.
end case
Similarity Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Keywords [?]

Isomerase
Glycolysis
Gluconeogenesis

Gene Ontology [?]

GO:0046538; Molecular function: 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity.
GO:0006094; Biological process: gluconeogenesis.
GO:0006096; Biological process: glycolytic process.

Cross-references [?]

Pfam PF00300; His_Phos_1; 1;
TIGRFAMs TIGR01258; pgm_1; 1;
PROSITE PS00175; PG_MUTASE; 1;

Features [?]

From: GPMA_ECOLI (P62707)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     10     17       Substrate binding     R-H-G-x-S-x(2)-[NK]  
REGION (Optional)     23     24       Substrate binding     [TS]-G  
REGION (Optional)     89     92       Substrate binding     E-[RK]-x-Y  
REGION (Optional)     116     117       Substrate binding     R-R  
REGION (Optional)     185     186       Substrate binding     G-N  
ACT_SITE     11     11       Tele-phosphohistidine intermediate     H  
ACT_SITE     89     89       Proton donor/acceptor     E  
BINDING (Optional)     62     62       Substrate     R  
BINDING (Optional)     100     100       Substrate     K  
SITE     184     184       Transition state stabilizer     H  

Additional information [?]

Size range 195-400 amino acids
Related rules MF_01040 (GPMB)
Fusion None


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