HAMAP rule MF_01042

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01042
Accession	MF_01042
Dates	28-FEB-2005 (Created) 22-AUG-2024 (Last updated, Version 17)
Name	SmrB
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	None
Triggered by	HAMAP; MF_01042 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SMRB
Protein name	RecName: Full=Ribosome rescue factor SmrB; EC=3.1.-.-;
Gene name	Name=smrB;

Comments [?]

FUNCTION	Acts as a ribosome collision sensor. Detects stalled/collided disomes (pairs of ribosomes where the leading ribosome is stalled and a second ribosome has collided with it) and endonucleolytically cleaves mRNA at the 5' boundary of the stalled ribosome. Stalled/collided disomes form a new interface (primarily via the 30S subunits) that binds SmrB. Cleaved mRNA becomes available for tmRNA ligation, leading to ribosomal subunit dissociation and rescue of stalled ribosomes.
SUBUNIT	Associates with collided ribosomes, but not with correctly translating polysomes.
SIMILARITY	Belongs to the SmrB family.

Keywords [?]

Gene Ontology [?]

GO:0019843; Molecular function:rRNA binding

GO:0004521; Molecular function:RNA endonuclease activity

GO:0072344; Biological process:rescue of stalled ribosome

Cross-references [?]

Pfam	PF01713; Smr; 1;
PROSITE	PS50828; SMR; 1;

Features [?]

Additional information [?]