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Annotation rule MF_01043
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General rule information [?]

Accession MF_01043
Dates 24-JAN-2003 (Created)
19-NOV-2019 (Last updated, Version 49)
Name PlsY
Scope
Bacteria
Templates P60782 (PLSY_ECOLI); Q45064 (PLSY_BACSU); P0A4Q0 (PLSY_STRR6): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PLSY
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Protein name
RecName: Full=Glycerol-3-phosphate acyltransferase;
AltName: Full=G3P acyltransferase;
Short=GPAT;
EC 2.3.1.15;
EC 2.3.1.n5;
AltName: Full=Lysophosphatidic acid synthase;
Short=LPA synthase;
else
Protein name
RecName: Full=Glycerol-3-phosphate acyltransferase;
AltName: Full=Acyl-PO4 G3P acyltransferase;
AltName: Full=Acyl-phosphate--glycerol-3-phosphate acyltransferase;
AltName: Full=G3P acyltransferase;
Short=GPAT;
EC 2.3.1.275;
AltName: Full=Lysophosphatidic acid synthase;
Short=LPA synthase;
end case
Gene name
plsY

Comments [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Function Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
Catalytic activity RHEA:15325: an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + CoA
EC 2.3.1.15
RHEA:42300: a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + holo-[ACP]
EC 2.3.1.n5
else
Function Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Catalytic activity RHEA:34075: an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate
EC 2.3.1.275
end case
Pathway Lipid metabolism; phospholipid metabolism.
Subunit Probably interacts with PlsX.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the PlsY family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
GO:0004366; Molecular function: glycerol-3-phosphate O-acyltransferase activity.
end case
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
GO:0043772; Molecular function: acyl-phosphate glycerol-3-phosphate acyltransferase activity.
end case
GO:0008654; Biological process: phospholipid biosynthetic process.

Cross-references [?]

Pfam PF02660; G3P_acyltransf; 1;
TIGRFAMs TIGR00023; TIGR00023; 1;

Computed features [?]

case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
General Transmembrane; -; 4-6; trigger=yes;
end case

Features [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
From: PLSY_ECOLI (P60782)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     1     3       Periplasmic        
TRANSMEM     4     24       Helical        
TOPO_DOM     25     52       Cytoplasmic        
TRANSMEM     53     73       Helical        
TOPO_DOM     74     80       Periplasmic        
TRANSMEM     81     101       Helical        
TOPO_DOM     102     111       Cytoplasmic        
TRANSMEM     112     132       Helical        
TOPO_DOM     133     137       Periplasmic        
TRANSMEM     138     158       Helical        
TOPO_DOM     159     205       Cytoplasmic        
end case

Additional information [?]

Size range 172-327 amino acids
Related rules None
Fusion None