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HAMAP rule MF_01043
General rule information
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| Accession | MF_01043 |
| Dates | 24-JAN-2003 (Created)
28-NOV-2023 (Last updated, Version 51) |
| Name | PlsY |
| Scope(s) |
Bacteria |
| Template(s) | P60782 (PLSY_ECOLI); Q45064 (PLSY_BACSU); P0A4Q0 (PLSY_STRR6); [ Recover all ] |
| Triggered by |
HAMAP; MF_01043 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PLSY |
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| Protein name | RecName: Full=Glycerol-3-phosphate acyltransferase; AltName: Full=G3P acyltransferase; Short=GPAT; EC=2.3.1.15; EC=2.3.1.n5; AltName: Full=Lysophosphatidic acid synthase; Short=LPA synthase; |
| else | |
| Protein name | RecName: Full=Glycerol-3-phosphate acyltransferase; AltName: Full=Acyl-PO4 G3P acyltransferase; AltName: Full=Acyl-phosphate--glycerol-3-phosphate acyltransferase; AltName: Full=G3P acyltransferase; Short=GPAT; EC=2.3.1.275; AltName: Full=Lysophosphatidic acid synthase; Short=LPA synthase; |
| end case | |
| Gene name | Name=plsY; |
Comments
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| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| FUNCTION | Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl- PO(4). |
| CATALYTIC ACTIVITY | Reaction=an acyl-CoA + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3- phosphate + CoA; Xref=Rhea:RHEA:15325, ChEBI:CHEBI:57287, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:58342; EC=2.3.1.15; |
| CATALYTIC ACTIVITY | Reaction=a fatty acyl-[ACP] + sn-glycerol 3-phosphate = a 1-acyl-sn- glycero-3-phosphate + holo-[ACP]; Xref=Rhea:RHEA:42300, Rhea:RHEA- COMP:9685, Rhea:RHEA-COMP:14125, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651; EC=2.3.1.n5; |
| else | |
| FUNCTION | Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. |
| CATALYTIC ACTIVITY | Reaction=an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn- glycero-3-phosphate + phosphate; Xref=Rhea:RHEA:34075, ChEBI:CHEBI:43474, ChEBI:CHEBI:57597, ChEBI:CHEBI:57970, ChEBI:CHEBI:59918; EC=2.3.1.275; |
| end case | |
| PATHWAY | Lipid metabolism; phospholipid metabolism. |
| SUBUNIT | Probably interacts with PlsX. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the PlsY family. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Lipid biosynthesis | |
| Lipid metabolism | |
| Membrane | |
| Phospholipid biosynthesis | |
| Phospholipid metabolism | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| case <OCellular component:Escherichia> or <OC:Shigella> or <OC:Salmonella> | |
| GO:0004366; Molecular function:glycerol-3-phosphate O-acyltransferase activity | |
| end case | |
| case not <OCellular component:Escherichia> and not <OC:Shigella> and not <OC:Salmonella> | |
| GO:0043772; Molecular function:acyl-phosphate glycerol-3-phosphate acyltransferase activity | |
| end case | |
| GO:0008654; Biological process:phospholipid biosynthetic process | |
Cross-references
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| Pfam | PF02660; G3P_acyltransf; 1; |
| NCBIfam | TIGR00023; TIGR00023; 1; |
| General | Transmembrane; -; 4-6; |
Features
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| From: PLSY_ECOLI (P60782) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | ||||||||||||
| TOPO_DOM | 1 | 3 | /note="Periplasmic" | |||||||||
| TRANSMEM | 4 | 24 | /note="Helical" | |||||||||
| TOPO_DOM | 25 | 52 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 53 | 73 | /note="Helical" | |||||||||
| TOPO_DOM | 74 | 80 | /note="Periplasmic" | |||||||||
| TRANSMEM | 81 | 101 | /note="Helical" | |||||||||
| TOPO_DOM | 102 | 111 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 112 | 132 | /note="Helical" | |||||||||
| TOPO_DOM | 133 | 137 | /note="Periplasmic" | |||||||||
| TRANSMEM | 138 | 158 | /note="Helical" | |||||||||
| TOPO_DOM | 159 | 205 | /note="Cytoplasmic" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 172-327 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |