HAMAP rule MF_01050

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01050
Accession	MF_01050
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 22)
Name	CaiB
Scope(s)	Bacteria Enterobacterales
Template(s)	P31572; Q8GB19; [ Recover all ]
Triggered by	HAMAP; MF_01050 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CAIB
Protein name	RecName: Full=L-carnitine CoA-transferase; EC=2.8.3.21; AltName: Full=Crotonobetainyl-CoA:carnitine CoA-transferase;
Gene name	Name=caiB;

Comments [?]

FUNCTION	Catalyzes the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA to L-carnitine to generate L-carnitinyl-CoA and gamma-butyrobetaine. Is also able to catalyze the reversible transfer of the CoA moiety from gamma-butyrobetainyl-CoA or L- carnitinyl-CoA to crotonobetaine to generate crotonobetainyl-CoA.
CATALYTIC ACTIVITY	Reaction=crotonobetainyl-CoA + (R)-carnitine = crotonobetaine + (R)- carnitinyl-CoA; Xref=Rhea:RHEA:28526, ChEBI:CHEBI:16347, ChEBI:CHEBI:17237, ChEBI:CHEBI:60932, ChEBI:CHEBI:60933; EC=2.8.3.21;
CATALYTIC ACTIVITY	Reaction=4-(trimethylamino)butanoyl-CoA + (R)-carnitine = (R)- carnitinyl-CoA + 4-(trimethylamino)butanoate; Xref=Rhea:RHEA:28418, ChEBI:CHEBI:16244, ChEBI:CHEBI:16347, ChEBI:CHEBI:60932, ChEBI:CHEBI:61513; EC=2.8.3.21;
PATHWAY	Amine and polyamine metabolism; carnitine metabolism.
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the CoA-transferase III family. CaiB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008410; Molecular function:CoA-transferase activity

GO:0009437; Biological process:carnitine metabolic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF02515; CoA_transf_3; 1;

Features [?]

From: CAIB_ECOLI (P31572)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

169

/note="Nucleophile"

BINDING

/ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"

BINDING

104

/ligand="CoA"
/ligand_id="ChEBI:CHEBI:57287"

Additional information [?]