HAMAP rule MF_01052
General rule information
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Accession | MF_01052 |
Dates | 26-MAR-2003 (Created)
15-DEC-2022 (Last updated, Version 20) |
Name | CaiA |
Scope(s) |
Bacteria Enterobacterales |
Template(s) | P60584 (CAIA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01052 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | CAIA |
Protein name | RecName: Full=Crotonobetainyl-CoA reductase; EC=1.3.8.13; AltName: Full=Crotonobetainyl-CoA dehydrogenase; |
Gene name | Name=caiA; |
Comments
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FUNCTION | Catalyzes the reduction of crotonobetainyl-CoA to gamma- butyrobetainyl-CoA. |
CATALYTIC ACTIVITY | Reaction=4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron- transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron- transfer flavoprotein]; Xref=Rhea:RHEA:51584, Rhea:RHEA-COMP:10685, Rhea:RHEA-COMP:10686, ChEBI:CHEBI:15378, ChEBI:CHEBI:57692, ChEBI:CHEBI:58307, ChEBI:CHEBI:60933, ChEBI:CHEBI:61513; EC=1.3.8.13; |
COFACTOR | Name=FAD; Xref=ChEBI:CHEBI:57692; |
PATHWAY | Amine and polyamine metabolism; carnitine metabolism. |
SUBUNIT | Homotetramer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the acyl-CoA dehydrogenase family. |
Keywords
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Gene Ontology
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GO:0052890; Molecular function:oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor |
GO:0009437; Biological process:carnitine metabolic process |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF00441; Acyl-CoA_dh_1; 1; |
Pfam | PF02770; Acyl-CoA_dh_M; 1; |
Pfam | PF02771; Acyl-CoA_dh_N; 1; |
PROSITE | PS00072; ACYL_COA_DH_1; 1; |
PROSITE | PS00073; ACYL_COA_DH_2; 1; |
Features
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Additional information
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Size range | 375-385 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |