HAMAP rule MF_01052

General rule information [?]

Accession	MF_01052
Dates	26-MAR-2003 (Created) 15-DEC-2022 (Last updated, Version 20)

Name

CaiA

Scope

Bacteria; Enterobacterales

Template

P60584 (CAIA_ECOLI)

Triggered by

HAMAP; MF_01052 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CAIA

Protein name

RecName:		Full=Crotonobetainyl-CoA reductase;
		EC 1.3.8.13;
AltName:		Full=Crotonobetainyl-CoA dehydrogenase;

Gene name

caiA

Comments [?]

Function	Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA.
Catalytic activity	RHEA:51584: 4-(trimethylamino)butanoyl-CoA + H(+) + oxidized [electron-transfer flavoprotein] = crotonobetainyl-CoA + reduced [electron-transfer flavoprotein] EC 1.3.8.13
Cofactor	FAD
Pathway	Amine and polyamine metabolism; carnitine metabolism.
Subunit	Homotetramer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the acyl-CoA dehydrogenase family.

Keywords [?]

Cytoplasm
FAD
Flavoprotein
Oxidoreductase

Gene Ontology [?]

GO:0052890; Molecular function: oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor.
GO:0009437; Biological process: carnitine metabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00441; Acyl-CoA_dh_1; 1;
	PF02770; Acyl-CoA_dh_M; 1;
	PF02771; Acyl-CoA_dh_N; 1;
PROSITE	PS00072; ACYL_COA_DH_1; 1;
	PS00073; ACYL_COA_DH_2; 1;

Additional information [?]

Size range	375-385 amino acids
Related rules	None
Fusion	None

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