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| Annotation rule MF_01074 |
General rule information
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| Accession | MF_01074 |
| Dates | 30-JUL-2003 (Created) 15-MAY-2020 (Last updated, Version 23) |
| Name | LarC |
| Scope | Bacteria
Archaea |
| Template | F9UST1 (LARC_LACPL) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
| Identifier |
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| Protein name |
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| Gene name |
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else
| Identifier |
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| Protein name |
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end case
Comments
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case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
| Function | Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. |
| Catalytic activity | RHEA:54784: Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
EC 4.99.1.12 |
end case
| Similarity | Belongs to the LarC family. |
Keywords
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Gene Ontology
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GO:0016151; Molecular function: nickel cation binding.
GO:0016829; Molecular function: lyase activity.
GO:0016829; Molecular function: lyase activity.
case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
GO:0051604; Biological process: protein maturation.
end case
Cross-references
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Additional information
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| Size range | 379-516 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range |