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Annotation rule MF_01074
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General rule information [?]

Accession MF_01074
Dates 30-JUL-2003 (Created)
15-MAY-2020 (Last updated, Version 23)
Name LarC
Scope
Bacteria
Archaea
Template F9UST1 (LARC_LACPL)

Propagated annotation [?]


Identifier, protein and gene names [?]

case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
Identifier
LARC
Protein name
RecName: Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein;
Short=P2TMN nickel insertion protein;
EC 4.99.1.12;
AltName: Full=Nickel-pincer cofactor biosynthesis protein LarC;
Gene name
larC
else
Identifier
Ynnn
Protein name
RecName: Full=Putative nickel insertion protein;
end case

Comments [?]

case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
Function Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Catalytic activity RHEA:54784: Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
EC 4.99.1.12
end case
Similarity Belongs to the LarC family.

Keywords [?]


Gene Ontology [?]

GO:0016151; Molecular function: nickel cation binding.
GO:0016829; Molecular function: lyase activity.
case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
GO:0051604; Biological process: protein maturation.
end case

Cross-references [?]

Pfam PF01969; DUF111; 1;
TIGRFAMs TIGR00299; TIGR00299; 1;

Additional information [?]

Size range 379-516 amino acids
Related rules None
Fusion None
Comments Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range