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HAMAP rule MF_01074

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General rule information [?]

Accession MF_01074
Dates 30-JUL-2003 (Created)
1-JUN-2023 (Last updated, Version 26)
Name LarC
Scope(s) Bacteria
Template(s) F9UST1 (LARC_LACPL); [ Recover all ]
Triggered by HAMAP; MF_01074 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
Identifier LARC
Protein name RecName: Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein;
                 Short=P2TMN nickel insertion protein;
AltName: Full=Nickel-pincer cofactor biosynthesis protein LarC;
Gene name Name=larC;
Identifier Ynnn
Protein name RecName: Full=Putative nickel insertion protein;
end case

Comments [?]

case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
FUNCTIONInvolved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
CATALYTIC ACTIVITY Reaction=Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide; Xref=Rhea:RHEA:54784, ChEBI:CHEBI:49786, ChEBI:CHEBI:137372, ChEBI:CHEBI:137373; EC=;
end case
SIMILARITYBelongs to the LarC family.

Keywords [?]

Gene Ontology [?]

GO:0016151; Molecular function:nickel cation binding
GO:0016829; Molecular function:lyase activity
case <OCellular component:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
GO:0051604; Biological process:protein maturation
end case

Cross-references [?]

Pfam PF01969; DUF111; 1;
NCBIfam TIGR00299; TIGR00299; 1;

Features [?]

Additional information [?]

Size range 379-516 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range

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