HAMAP rule MF_01074
General rule information
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Accession | MF_01074 |
Dates | 30-JUL-2003 (Created) 1-JUN-2023 (Last updated, Version 26) |
Name | LarC |
Scope | Bacteria
Archaea |
Template | F9UST1 (LARC_LACPL) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
Identifier |
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Protein name |
|
Gene name |
|
else
Identifier |
|
Protein name |
|
end case
Comments
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case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
Function | Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. |
Catalytic activity | RHEA:54784: Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
EC 4.99.1.12 |
end case
Similarity | Belongs to the LarC family. |
Keywords
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Gene Ontology
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GO:0016151; Molecular function: nickel cation binding.
GO:0016829; Molecular function: lyase activity.
GO:0016829; Molecular function: lyase activity.
case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
GO:0051604; Biological process: protein maturation.
end case
Cross-references
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Additional information
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Size range | 379-516 amino acids |
Related rules | None |
Fusion | None |
Comments | Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range |