HAMAP rule MF_01074

General rule information [?]

Accession	MF_01074
Dates	30-JUL-2003 (Created) 1-JUN-2023 (Last updated, Version 26)

Name

LarC

Scope

Bacteria

Archaea

Template

F9UST1 (LARC_LACPL)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>

Identifier

LARC

Protein name

RecName:		Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein;
		Short=P2TMN nickel insertion protein;
		EC 4.99.1.12;
AltName:		Full=Nickel-pincer cofactor biosynthesis protein LarC;

Gene name

larC

else

Identifier

Ynnn

Protein name

RecName:

Full=Putative nickel insertion protein;

end case

Comments [?]

case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>

Function	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Catalytic activity	RHEA:54784: Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide EC 4.99.1.12

end case

Similarity

Belongs to the LarC family.

Keywords [?]

Gene Ontology [?]

GO:0016151; Molecular function: nickel cation binding.
GO:0016829; Molecular function: lyase activity.

case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>

GO:0051604; Biological process: protein maturation.

end case

Cross-references [?]

Pfam	PF01969; DUF111; 1;
NCBIfam	TIGR00299; TIGR00299; 1;

Additional information [?]

Size range	379-516 amino acids
Related rules	None
Fusion	None
Comments	Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range