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Annotation rule MF_01074 |
General rule information
[?]
Accession |
MF_01074 |
Dates |
30-JUL-2003 (Created) 15-MAY-2020 (Last updated, Version 23) |
Propagated annotation
[?]
Identifier, protein and gene names
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case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
Protein name |
RecName:
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Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein;
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Short=P2TMN nickel insertion protein;
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EC 4.99.1.12;
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AltName:
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Full=Nickel-pincer cofactor biosynthesis protein LarC;
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else
Protein name |
RecName:
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Full=Putative nickel insertion protein;
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end case
case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
Function |
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. |
Catalytic activity |
RHEA:54784: Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide = Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide
EC 4.99.1.12
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end case
Similarity |
Belongs to the LarC family. |
GO:0016151; Molecular function: nickel cation binding.
GO:0016829; Molecular function: lyase activity.
case <OC:Firmicutes> or <OC:Verrucomicrobia> or <OC:Actinobacteria> or <OC:Thermotogae>
GO:0051604; Biological process: protein maturation.
end case
Additional information
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Size range |
379-516 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
Shorter N-terminal in ENTFA; not shown in alignment and not taken into account in size range |