HAMAP rule MF_01075

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01075
Accession	MF_01075
Dates	28-FEB-2005 (Created) 03-SEP-2024 (Last updated, Version 35)
Name	NhaP2
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	A5F4U3; Q87KV8; P76007; [ Recover all ]
Triggered by	HAMAP; MF_01075 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	NHAP2
Protein name	RecName: Full=K(+)/H(+) antiporter NhaP2; AltName: Full=Potassium/proton antiporter NhaP2;
Gene name	Name=nhaP2;

Comments [?]

FUNCTION	K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
CATALYTIC ACTIVITY	Reaction=K(+)(in) + H(+)(out) = K(+)(out) + H(+)(in); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29468;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.

Keywords [?]

Antiport
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Ion transport
Membrane
Potassium
Potassium transport
Transmembrane
Transmembrane helix
Transport

Gene Ontology [?]

GO:0015386; Molecular function:potassium:proton antiporter activity

GO:0015079; Molecular function:potassium ion transmembrane transporter activity

GO:0071805; Biological process:potassium ion transmembrane transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]