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HAMAP rule MF_01075

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General rule information [?]

Accession MF_01075
Dates 11-AUG-2003 (Created)
29-SEP-2022 (Last updated, Version 36)
Name NhaP2
Scope(s) Bacteria
Template(s) A5F4U3 (NHAP2_VIBC3); Q87KV8 (NHAP2_VIBPA); P76007 (NHAP2_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01075 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NHAP2
Protein name RecName: Full=K(+)/H(+) antiporter NhaP2;
AltName: Full=Potassium/proton antiporter NhaP2;
Gene name Name=nhaP2;

Comments [?]

FUNCTIONK(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
CATALYTIC ACTIVITY Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out); Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29468;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0015386; Molecular function:potassium:proton antiporter activity
GO:0015079; Molecular function:potassium ion transmembrane transporter activity
GO:0071805; Biological process:potassium ion transmembrane transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03471; CorC_HlyC; 1;
Pfam PF00999; Na_H_Exchanger; 1;
Pfam PF02080; TrkA_C; 1;
PROSITE PS51202; RCK_C; 1;
General Transmembrane; -; 10-13;

Features [?]

Additional information [?]

Size range 538-640 amino acids
Related rules None
Fusion Nter: None Cter: None

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