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HAMAP rule MF_01075

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General rule information [?]

Accession MF_01075
Dates 11-AUG-2003 (Created)
29-SEP-2022 (Last updated, Version 36)
Name NhaP2
Bacteria; Gammaproteobacteria
Templates A5F4U3 (NHAP2_VIBC3); Q87KV8 (NHAP2_VIBPA); P76007 (NHAP2_ECOLI): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=K(+)/H(+) antiporter NhaP2;
AltName: Full=Potassium/proton antiporter NhaP2;
Gene name

Comments [?]

Function K(+)/H(+) antiporter that extrudes potassium in exchange for external protons and maintains the internal concentration of potassium under toxic levels.
Catalytic activity RHEA:29467: H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out)
PhysiologicalDirection=left-to-right (RHEA:29468)
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. NhaP2 subfamily.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0015386; Molecular function: potassium:proton antiporter activity.
GO:0015079; Molecular function: potassium ion transmembrane transporter activity.
GO:0071805; Biological process: potassium ion transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF03471; CorC_HlyC; 1;
PF00999; Na_H_Exchanger; 1;
PF02080; TrkA_C; 1;
PROSITE PS51202; RCK_C; 1; trigger=PRU00544;

Computed features [?]

General Transmembrane; -; 10-13; trigger=yes;

Additional information [?]

Size range 538-640 amino acids
Related rules None
Fusion None