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Annotation rule MF_01081
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General rule information [?]

Accession MF_01081
Dates 25-SEP-2003 (Created)
19-NOV-2019 (Last updated, Version 23)
Name TruB_arch
Scope
Archaea
Templates P60340 (TRUB_ECOLI); P9WHP7 (TRUB_MYCTU); Q9WZW0 (TRUB_THEMA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TRUB
Protein name
RecName: Full=Probable tRNA pseudouridine synthase B;
EC 5.4.99.25;
AltName: Full=tRNA pseudouridine(55) synthase;
Short=Psi55 synthase;
AltName: Full=tRNA pseudouridylate synthase;
AltName: Full=tRNA-uridine isomerase;
Gene name
truB

Comments [?]

Function Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Catalytic activity RHEA:42532: uridine(55) in tRNA = pseudouridine(55) in tRNA
EC 5.4.99.25
Similarity Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.

Keywords [?]

Isomerase
tRNA processing

Gene Ontology [?]

GO:0009982; Molecular function: pseudouridine synthase activity.
GO:0031119; Biological process: tRNA pseudouridine synthesis.

Cross-references [?]

Pfam PF01472; PUA; 1;
PF01509; TruB_N; 1;
TIGRFAMs TIGR00425; CBF5; 1;
TIGR00451; Unchar_dom_2; 1;
TIGR00431; TruB; 1;
PROSITE PS50890; PUA; 0-1; trigger=PRU00161;

Features [?]

From: TRUB_ARCFU (O30001)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     69     69       Nucleophile     D  

Additional information [?]

Size range 301-365 amino acids
Related rules MF_01080 (TRUB)
Fusion None
Comments Active site is not conserved in AERPE. Shorter N-terminal in SACS2; not shown in alignment and not taken into account in size range.


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