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HAMAP rule MF_01081

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General rule information [?]

Accession MF_01081
Dates 25-SEP-2003 (Created)
1-JUN-2023 (Last updated, Version 24)
Name TruB_arch
Scope(s) Archaea
Template(s) P60340 (TRUB_ECOLI); P9WHP7 (TRUB_MYCTU); Q9WZW0 (TRUB_THEMA); [ Recover all ]
Triggered by HAMAP; MF_01081 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TRUB
Protein name RecName: Full=Probable tRNA pseudouridine synthase B;
AltName: Full=tRNA pseudouridine(55) synthase;
                 Short=Psi55 synthase;
AltName: Full=tRNA pseudouridylate synthase;
AltName: Full=tRNA-uridine isomerase;
Gene name Name=truB;

Comments [?]

FUNCTIONCould be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
CATALYTIC ACTIVITY Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA; Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=;
SIMILARITYBelongs to the pseudouridine synthase TruB family. Type 2 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0009982; Molecular function:pseudouridine synthase activity
GO:0031119; Biological process:tRNA pseudouridine synthesis

Cross-references [?]

Pfam PF01472; PUA; 1;
Pfam PF01509; TruB_N; 1;
NCBIfam TIGR00425; CBF5; 1;
NCBIfam TIGR00451; Unchar_dom_2; 1;
NCBIfam TIGR00431; TruB; 1;
PROSITE PS50890; PUA; 0-1;

Features [?]

From: TRUB_ARCFU (O30001)
Key From To Description Tag Condition FTGroup
ACT_SITE 69 69 /note="Nucleophile" D

Additional information [?]

Size range 301-365 amino acids
Related rules MF_01080
Fusion Nter: None Cter: None
Comments Active site is not conserved in AERPE. Shorter N-terminal in SACS2; not shown in alignment and not taken into account in size range.

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