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HAMAP rule MF_01083

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General rule information [?]

Accession MF_01083
Dates 30-SEP-2003 (Created)
19-NOV-2022 (Last updated, Version 19)
Name glutarate_hydroxylase
Scope(s) Bacteria
Template(s) P76621 (GLAH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01083 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GLAH
Protein name RecName: Full=Glutarate 2-hydroxylase;
Gene name Name=glaH;

Comments [?]

FUNCTIONActs as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
CATALYTIC ACTIVITY Reaction=2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate; Xref=Rhea:RHEA:13821, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:30921; EC=; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13822;
case <FTGroup:1>
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit
end case
PATHWAYAmino-acid degradation.
SIMILARITYBelongs to the glutarate hydroxylase family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0050498; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
GO:0019477; Biological process:L-lysine catabolic process
case <FTGroup:1>
GO:0008198; Molecular function:ferrous iron binding
end case

Cross-references [?]

Pfam PF08943; CsiD; 1;

Features [?]

From: GLAH_ECOLI (P76621)
Key From To Description Tag Condition FTGroup
BINDING 160 160 /ligand="Fe cation"
H 1
BINDING 162 162 /ligand="Fe cation"
D 1
BINDING 292 292 /ligand="Fe cation"
H 1

Additional information [?]

Size range 310-325 amino acids
Related rules None
Fusion Nter: None Cter: None

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