Home  |  Contact
Annotation rule MF_01083
Send feedback

General rule information [?]

Accession MF_01083
Dates 30-SEP-2003 (Created)
4-APR-2020 (Last updated, Version 17)
Name glutarate_hydroxylase
Scope
Bacteria; Enterobacterales
Bacteria; Pseudomonadaceae
Template P76621 (GLAH_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GLAH
Protein name
RecName: Full=Glutarate 2-hydroxylase;
Short=G-2-H;
EC 1.14.11.64;
Gene name
glaH

Comments [?]

Function Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
Catalytic activity RHEA:13821: 2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate
EC 1.14.11.64
PhysiologicalDirection=left-to-right (RHEA:13822)
case <FTGroup:1>
Cofactor Fe(2+)
Note: Binds 1 Fe(2+) ion per subunit
end case
Pathway Amino-acid degradation.
Subunit Homotetramer.
Similarity Belongs to the glutarate hydroxylase family.

Keywords [?]

Dioxygenase
Oxidoreductase
case <FTGroup:1>
Metal-binding
Iron
end case

Gene Ontology [?]

GO:0050498; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated.
GO:0019477; Biological process: L-lysine catabolic process.
case <FTGroup:1>
GO:0008198; Molecular function: ferrous iron binding.
end case

Cross-references [?]

Pfam PF08943; CsiD; 1;

Features [?]

From: GLAH_ECOLI (P76621)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     160     160       Iron     H   1
METAL     162     162       Iron     D   1
METAL     292     292       Iron     H   1

Additional information [?]

Size range 310-325 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)