HAMAP rule MF_01083
General rule information
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| Accession | MF_01083 |
| Dates | 30-SEP-2003 (Created)
19-NOV-2022 (Last updated, Version 19) |
| Name | glutarate_hydroxylase |
| Scope(s) |
Bacteria Enterobacterales Pseudomonadaceae |
| Template(s) | P76621 (GLAH_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01083 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | GLAH |
| Protein name | RecName: Full=Glutarate 2-hydroxylase; Short=G-2-H; EC=1.14.11.64; |
| Gene name | Name=glaH; |
Comments
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| FUNCTION | Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
| CATALYTIC ACTIVITY | Reaction=2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate; Xref=Rhea:RHEA:13821, ChEBI:CHEBI:15379, ChEBI:CHEBI:16526, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031, ChEBI:CHEBI:30921; EC=1.14.11.64; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13822; |
| case <FTGroup:1> | |
| COFACTOR | Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit |
| end case | |
| PATHWAY | Amino-acid degradation. |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the glutarate hydroxylase family. |
Keywords
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| Dioxygenase | |
| Oxidoreductase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Iron | |
| end case | |
Gene Ontology
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| GO:0050498; Molecular function:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated | |
| GO:0019477; Biological process:L-lysine catabolic process | |
| case <FTGroup:1> | |
| GO:0008198; Molecular function:ferrous iron binding | |
| end case | |
Cross-references
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| Pfam | PF08943; CsiD; 1; |
Features
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| From: GLAH_ECOLI (P76621) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 160 | 160 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | 1 | |||||||
| BINDING | 162 | 162 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
D | 1 | |||||||
| BINDING | 292 | 292 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875" |
H | 1 | |||||||
Additional information
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| Size range | 310-325 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |