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Annotation rule MF_01083 |
Accession | MF_01083 |
Dates | 30-SEP-2003 (Created) 4-APR-2020 (Last updated, Version 17) |
Name | glutarate_hydroxylase |
Scope | Bacteria; Enterobacterales
Bacteria; Pseudomonadaceae |
Template | P76621 (GLAH_ECOLI) |
Triggered by |
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Protein name |
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Gene name |
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Function | Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
Catalytic activity | RHEA:13821: 2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate
EC 1.14.11.64 PhysiologicalDirection=left-to-right (RHEA:13822) |
Cofactor | Fe(2+) Note: Binds 1 Fe(2+) ion per subunit |
Pathway | Amino-acid degradation. |
Subunit | Homotetramer. |
Similarity | Belongs to the glutarate hydroxylase family. |
Pfam | PF08943; CsiD; 1; |
From: GLAH_ECOLI (P76621) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
METAL | 160 | 160 | Iron | H | 1 | |||||||
METAL | 162 | 162 | Iron | D | 1 | |||||||
METAL | 292 | 292 | Iron | H | 1 |
Size range | 310-325 amino acids |
Related rules | None |
Fusion | None |