HAMAP rule MF_01083
General rule information
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| Accession | MF_01083 |
| Dates | 30-SEP-2003 (Created) 19-NOV-2022 (Last updated, Version 19) |
| Name | glutarate_hydroxylase |
| Scope | Bacteria; Enterobacterales
Bacteria; Pseudomonadaceae |
| Template | P76621 (GLAH_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Acts as an alpha-ketoglutarate-dependent dioxygenase catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate (L2HG). Functions in a L-lysine degradation pathway that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate. |
| Catalytic activity | RHEA:13821: 2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2 + succinate
EC 1.14.11.64 PhysiologicalDirection=left-to-right (RHEA:13822) |
case <FTGroup:1>
| Cofactor | Fe(2+) Note: Binds 1 Fe(2+) ion per subunit |
end case
| Pathway | Amino-acid degradation. |
| Subunit | Homotetramer. |
| Similarity | Belongs to the glutarate hydroxylase family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0050498; Molecular function: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated.
GO:0019477; Biological process: L-lysine catabolic process.
GO:0019477; Biological process: L-lysine catabolic process.
case <FTGroup:1>
GO:0008198; Molecular function: ferrous iron binding.
end case
Cross-references
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| Pfam | PF08943; CsiD; 1; |
Features
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| From: GLAH_ECOLI (P76621) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 160 | 160 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | H | 1 | |||||||
| BINDING | 162 | 162 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | D | 1 | |||||||
| BINDING | 292 | 292 | /ligand="Fe cation" /ligand_id="ChEBI:CHEBI:24875 | H | 1 | |||||||
Additional information
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| Size range | 310-325 amino acids |
| Related rules | None |
| Fusion | None |