HAMAP rule MF_01097
General rule information
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| Accession | MF_01097 |
| Dates | 28-NOV-2003 (Created)
15-APR-2024 (Last updated, Version 28) |
| Name | MtrD |
| Scope(s) |
Archaea |
| Template(s) | P80183 (MTRD_METTM); [ Recover all ] |
| Triggered by |
HAMAP; MF_01097 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTRD |
| Protein name | RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit D; EC=7.2.1.4; AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit D; |
| Gene name | Name=mtrD; |
Comments
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| FUNCTION | Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. |
| CATALYTIC ACTIVITY | Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101, ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286, ChEBI:CHEBI:58319; EC=7.2.1.4; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| PATHWAY | One-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. |
| end case | |
| SUBUNIT | The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the MtrD family. |
Keywords
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Methanogenesis | |
| end case | |
| One-carbon metabolism | |
| Transferase | |
| <a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
| Methyltransferase | |
| Cell membrane | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0030269; Molecular function:tetrahydromethanopterin S-methyltransferase activity | |
| GO:0006730; Biological process:one-carbon metabolic process | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| GO:0019386; Biological process:methanogenesis, from carbon dioxide | |
| end case | |
| GO:0005886; Cellular component:plasma membrane | |
Cross-references
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| Pfam | PF04207; MtrD; 1; |
| NCBIfam | TIGR01112; MtrD; 1; |
| General | Transmembrane; -; 6; |
Features
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Additional information
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| Size range | 225-250 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |