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HAMAP rule MF_01100

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General rule information [?]

Accession MF_01100
Dates 16-JUL-2002 (Created)
19-NOV-2022 (Last updated, Version 31)
Name 5DNU
Scope(s) Bacteria
Gammaproteobacteria
Template(s) P76491 (5DNU_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01100 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier 5DNU
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Protein name RecName: Full=5'-deoxynucleotidase YfbR;
                 EC=3.1.3.89;
AltName: Full=5'-deoxyribonucleotidase;
AltName: Full=Nucleoside 5'-monophosphate phosphohydrolase;
Gene name Name=yfbR;
end case
case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
Protein name RecName: Full=5'-deoxynucleotidase ;
                 EC=3.1.3.89;
AltName: Full=5'-deoxyribonucleotidase;
AltName: Full=Nucleoside 5'-monophosphate phosphohydrolase;
end case

Comments [?]

FUNCTIONCatalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates.
CATALYTIC ACTIVITY Reaction=a 2'-deoxyribonucleoside 5'-phosphate + H2O = a 2'- deoxyribonucleoside + phosphate; Xref=Rhea:RHEA:36167, ChEBI:CHEBI:15377, ChEBI:CHEBI:18274, ChEBI:CHEBI:43474, ChEBI:CHEBI:65317; EC=3.1.3.89;
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
SUBUNITHomodimer.
SUBCELLULAR LOCATIONCytoplasm.
SIMILARITYBelongs to the 5DNU family.

Keywords [?]


Gene Ontology [?]

GO:0016791; Molecular function:phosphatase activity

Cross-references [?]

Pfam PF01966; HD; 1;
Pfam PF13023; HD_3; 1;
PROSITE PS51831; HD; 1;

Features [?]

From: 5DNU_ECOLI (P76491)
Key From To Description Tag Condition FTGroup
BINDING 18 19 /ligand="substrate" R-W
BINDING 77 80 /ligand="substrate" D-x-x-T
BINDING 33 33 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
H
BINDING 68 68 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
H
BINDING 69 69 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
D
BINDING 137 137 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
D
BINDING 33 33 /ligand="substrate" H
BINDING 69 69 /ligand="substrate" D
BINDING 137 137 /ligand="substrate" D
SITE 18 18 /note="Appears to be important in orienting the phosphate for catalysis" R

Additional information [?]

Size range 194-199 amino acids
Related rules None
Fusion Nter: None Cter: None



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