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Annotation rule MF_01102 |
Accession | MF_01102 |
Dates | 16-JUL-2002 (Created) 19-NOV-2019 (Last updated, Version 30) |
Name | MnmC |
Scope | Bacteria; Proteobacteria
Bacteria; Spirochaetes |
Template | P77182 (MNMC_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34. |
Catalytic activity | RHEA:19569: 5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.61 |
Cofactor | FAD |
Subcellular location | Cytoplasm. |
Similarity | In the N-terminal section; belongs to the methyltransferase superfamily. tRNA (mnm(5)s(2)U34)-methyltransferase family. |
In the C-terminal section; belongs to the DAO family. |
From: MNMC_ECOLI (P77182) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | Nter | 245 | tRNA (mnm(5)s(2)U34)-methyltransferase | |||||||||
REGION | 270 | Cter | FAD-dependent cmnm(5)s(2)U34 oxidoreductase |
Size range | 585-754 amino acids |
Related rules | None |
Fusion | None |