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HAMAP rule MF_01105

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General rule information [?]

Accession MF_01105
Dates 10-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 36)
Name N_acetyl_glu_synth
Scope(s) Bacteria
Template(s) P0A6C5 (ARGA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARGA
Protein name RecName: Full=Amino-acid acetyltransferase;
AltName: Full=N-acetylglutamate synthase;
Gene name Name=argA;

Comments [?]

CATALYTIC ACTIVITY Reaction=acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate; Xref=Rhea:RHEA:24292, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:44337, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=;
PATHWAYAmino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 1/4.
case <OC:Enterobacterales>
end case
case not <OC:Enterobacterales> and not <OC:Pseudomonadaceae> and not <OC:Vibrionaceae>
MISCELLANEOUSIn bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.
end case
SIMILARITYBelongs to the acetyltransferase family. ArgA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004042; Molecular function:acetyl-CoA:L-glutamate N-acetyltransferase activity
GO:0006526; Biological process:arginine biosynthetic process
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
Pfam PF00583; Acetyltransf_1; 1;
PIRSF PIRSF000423; ArgA; 1;
NCBIfam TIGR01890; N-Ac-Glu-synth; 1;

Features [?]

Additional information [?]

Size range 432-451 amino acids
Related rules None
Fusion Nter: MF_00006 (argH) Cter: None
Comments Moritella sp. argA is fusioned in its N-terminal part to argH. The NAT domain is not shown here - it is much smaller than other acetylglutamate synthases.

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