HAMAP rule MF_01105

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01105
Accession	MF_01105
Dates	28-FEB-2005 (Created) 05-NOV-2024 (Last updated, Version 31)
Name	N_acetyl_glu_synth
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0A6C5; [ Recover all ]
Triggered by	HAMAP; MF_01105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ARGA
Protein name	RecName: Full=Amino-acid acetyltransferase; EC=2.3.1.1; AltName: Full=N-acetylglutamate synthase; Short=AGS; Short=NAGS;
Gene name	Name=argA;

Comments [?]

CATALYTIC ACTIVITY	Reaction=L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+); Xref=Rhea:RHEA:24292, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:44337, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=2.3.1.1;
PATHWAY	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 1/4.
case <OC:Enterobacterales>
SUBUNIT	Homohexamer.
end case
SUBCELLULAR LOCATION	Cytoplasm.
case not <OC:Enterobacterales> and not <OC:Pseudomonadaceae> and not <OC:Vibrionaceae>
MISCELLANEOUS	In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.
end case
SIMILARITY	Belongs to the acetyltransferase family. ArgA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004042; Molecular function:L-glutamate N-acetyltransferase activity

GO:0006526; Biological process:L-arginine biosynthetic process

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]

Size range	432-451 amino acids
Related rules	None
Fusion	Nter: MF_00006 (argH) Cter: None
Comments	Moritella sp. argA is fusioned in its N-terminal part to argH. The NAT domain is not shown here - it is much smaller than other acetylglutamate synthases.