HAMAP rule MF_01105

General rule information [?]

Accession	MF_01105
Dates	10-FEB-2003 (Created) 1-JUN-2023 (Last updated, Version 36)

Name	N_acetyl_glu_synth

Scope

Bacteria; Pseudomonadota

Template

P0A6C5 (ARGA_ECOLI)

Triggered by

HAMAP; MF_01105 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ARGA

Protein name

RecName:		Full=Amino-acid acetyltransferase;
		EC 2.3.1.1;
AltName:		Full=N-acetylglutamate synthase;
		Short=AGS;
		Short=NAGS;

Gene name

argA

Comments [?]

Catalytic activity	RHEA:24292: acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate EC 2.3.1.1
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.

case <OC:Enterobacterales>

Subunit

Homohexamer.

end case

Subcellular location

Cytoplasm.

case not <OC:Enterobacterales> and not <OC:Pseudomonadaceae> and not <OC:Vibrionaceae>

Miscellaneous

In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.

end case

Similarity

Belongs to the acetyltransferase family. ArgA subfamily.

Keywords [?]

Cytoplasm
Amino-acid biosynthesis
Arginine biosynthesis
Transferase
Acyltransferase

Gene Ontology [?]

GO:0004042; Molecular function: acetyl-CoA:L-glutamate N-acetyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00696; AA_kinase; 1;
	PF00583; Acetyltransf_1; 1;
PIRSF	PIRSF000423; ArgA; 1;
NCBIfam	TIGR01890; N-Ac-Glu-synth; 1;
PROSITE	PS51186; GNAT; 1; trigger=PRU00532;

Additional information [?]

Size range	432-451 amino acids
Related rules	None
Fusion	Nter: MF_00006 (argH); Cter: None
Comments	Moritella sp. argA is fusioned in its N-terminal part to argH. The NAT domain is not shown here - it is much smaller than other acetylglutamate synthases.

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