HAMAP logo

HAMAP rule MF_01105

Send feedback

General rule information [?]

Accession MF_01105
Dates 10-FEB-2003 (Created)
1-JUN-2023 (Last updated, Version 36)
Name N_acetyl_glu_synth
Bacteria; Pseudomonadota
Template P0A6C5 (ARGA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Amino-acid acetyltransferase;
AltName: Full=N-acetylglutamate synthase;
Gene name

Comments [?]

Catalytic activity RHEA:24292: acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate
Pathway Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.
case <OC:Enterobacterales>
Subunit Homohexamer.
end case
Subcellular location Cytoplasm.
case not <OC:Enterobacterales> and not <OC:Pseudomonadaceae> and not <OC:Vibrionaceae>
Miscellaneous In bacteria which possess the bifunctional enzyme ornithine acetyltransferase/N-acetylglutamate synthase (ArgJ), ArgA fulfills an anaplerotic role.
end case
Similarity Belongs to the acetyltransferase family. ArgA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0004042; Molecular function: acetyl-CoA:L-glutamate N-acetyltransferase activity.
GO:0006526; Biological process: arginine biosynthetic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00696; AA_kinase; 1;
PF00583; Acetyltransf_1; 1;
PIRSF PIRSF000423; ArgA; 1;
NCBIfam TIGR01890; N-Ac-Glu-synth; 1;
PROSITE PS51186; GNAT; 1; trigger=PRU00532;

Additional information [?]

Size range 432-451 amino acids
Related rules None
Fusion Nter: MF_00006 (argH); Cter: None
Comments Moritella sp. argA is fusioned in its N-terminal part to argH. The NAT domain is not shown here - it is much smaller than other acetylglutamate synthases.