HAMAP rule MF_01108
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_01108 |
| Accession | MF_01108 |
| Dates | 28-FEB-2005 (Created)
05-NOV-2024 (Last updated, Version 33) |
| Name | ArgE |
| Scope(s) |
Bacteria Enterobacterales Vibrionales |
| Template(s) | P23908; [ Recover all ] |
| Triggered by |
HAMAP; MF_01108 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | ARGE |
| Protein name | RecName: Full=Acetylornithine deacetylase; Short=AO; Short=Acetylornithinase; EC=3.5.1.16; AltName: Full=N-acetylornithinase; Short=NAO; |
| Gene name | Name=argE; |
Comments
[?]
| FUNCTION | Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines. |
| CATALYTIC ACTIVITY | Reaction=N(2)-acetyl-L-ornithine + H2O = L-ornithine + acetate; Xref=Rhea:RHEA:15941, ChEBI:CHEBI:15377, ChEBI:CHEBI:30089, ChEBI:CHEBI:46911, ChEBI:CHEBI:57805; EC=3.5.1.16; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Name=Co(2+); Xref=ChEBI:CHEBI:48828; Note=Binds 2 Zn(2+) or Co(2+) ions per subunit.; |
| COFACTOR | Name=glutathione; Xref=ChEBI:CHEBI:57925; |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the peptidase M20A family. ArgE subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0008777; Molecular function:acetylornithine deacetylase activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0006526; Biological process:L-arginine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
| Pfam | PF01546; Peptidase_M20; 1; |
| NCBIfam | TIGR01892; AcOrn-deacetyl; 1; |
| PROSITE | PS00758; ARGE_DAPE_CPG2_1; 1; |
| PROSITE | PS00759; ARGE_DAPE_CPG2_2; 1; |
Features
[?]
| From: ARGE_ECOLI (P23908) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 82 | 82 | D | |||||||||
| ACT_SITE | 144 | 144 | E | |||||||||
| BINDING | 80 | 80 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 112 | 112 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
| BINDING | 112 | 112 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
D | ||||||||
| BINDING | 145 | 145 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
E | ||||||||
| BINDING | 169 | 169 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
E | ||||||||
| BINDING | 355 | 355 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
Additional information
[?]
| Size range | 378-389 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |