HAMAP rule MF_01110
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01110 |
| Accession | MF_01110 |
| Dates | 28-FEB-2005 (Created)
05-NOV-2024 (Last updated, Version 26) |
| Name | ArgC_type2 |
| Scope(s) |
Bacteria |
| Template(s) | P11446; [ Recover all ] |
| Triggered by |
HAMAP; MF_01110 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ARGC |
| Protein name | RecName: Full=N-acetyl-gamma-glutamyl-phosphate reductase; Short=AGPR; EC=1.2.1.38; AltName: Full=N-acetyl-glutamate semialdehyde dehydrogenase; Short=NAGSA dehydrogenase; |
| Gene name | Name=argC; |
Comments
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| FUNCTION | Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. |
| CATALYTIC ACTIVITY | Reaction=N-acetyl-L-glutamate 5-semialdehyde + phosphate + NADP(+) = N- acetyl-L-glutamyl 5-phosphate + NADPH + H(+); Xref=Rhea:RHEA:21588, ChEBI:CHEBI:15378, ChEBI:CHEBI:29123, ChEBI:CHEBI:43474, ChEBI:CHEBI:57783, ChEBI:CHEBI:57936, ChEBI:CHEBI:58349; EC=1.2.1.38; |
| PATHWAY | Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl- L-ornithine from L-glutamate: step 3/4. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. |
Keywords
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Gene Ontology
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| GO:0003942; Molecular function:N-acetyl-gamma-glutamyl-phosphate reductase activity |
| GO:0006526; Biological process:L-arginine biosynthetic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: ARGC_DEIRA (Q9RY72) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 117 | 117 | C | |||||||||
Additional information
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| Size range | 295-360 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | See MF_00150 for ArgC type 1 subfamily. |