HAMAP rule MF_01116
General rule information
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Accession | MF_01116 |
Dates | 27-NOV-2003 (Created)
19-NOV-2022 (Last updated, Version 26) |
Name | TSR3 |
Scope(s) |
Archaea |
Template(s) | Q12094 (TSR3_YEAST); E1QU22 (TSR3_VULDI); [ Recover all ] |
Triggered by |
case c? <OC:Archaea>
HAMAP; MF_01116 (Get profile general information and statistics) end case
|
Propagated annotation
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Identifier, protein and gene names
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Identifier | TSR3 |
Protein name | RecName: Full=16S rRNA aminocarboxypropyltransferase; EC=2.5.1.-; |
Comments
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FUNCTION | Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3- carboxypropyl) pseudouridine (m1acp3-Psi). |
CATALYTIC ACTIVITY | Reaction=an N(1)-methylpseudouridine in 16S/18S rRNA + S-adenosyl-L- methionine = H(+) + N(1)-methyl-N(3)[(3S)-3-amino-3- carboxypropyl]pseudouridine in 16S/18S rRNA + S-methyl-5'- thioadenosine; Xref=Rhea:RHEA:63296, Rhea:RHEA-COMP:11634, Rhea:RHEA- COMP:16310, ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:59789, ChEBI:CHEBI:74890, ChEBI:CHEBI:146234; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the TDD superfamily. TSR3 family. |
Keywords
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Gene Ontology
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GO:0005737; Cellular component:cytoplasm |
GO:1904047; Molecular function:S-adenosyl-L-methionine binding |
GO:0000455; Biological process:enzyme-directed rRNA pseudouridine synthesis |
GO:0006364; Biological process:rRNA processing |
Cross-references
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Features
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From: TSR3_VULDI (E1QU22) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 19 | 19 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[TS] | ||||||||
BINDING | 69 | 69 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[IVL] | ||||||||
BINDING | 93 | 93 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[LI] | ||||||||
BINDING | 108 | 108 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[YW] | ||||||||
BINDING | 112 | 112 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789" |
[TS] |
Additional information
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Size range | 163-208 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |