HAMAP logo

HAMAP rule MF_01134

Send feedback

General rule information [?]

Accession MF_01134
Dates 20-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 14)
Name CdhB
Scope(s) Archaea
Template(s) Q9C4Z3 (ACDE2_METTE); Q46G05 (ACDE1_METBF); [ Recover all ]
Triggered by HAMAP; MF_01134 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACDE
Protein name RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit epsilon;
                 Short=ACDS complex subunit epsilon;
AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit epsilon;
                 Short=ACDS CODH subunit epsilon;
Gene name Name=cdhB;

Comments [?]

case <OC:Methanosarcinaceae>
FUNCTIONPart of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation.
end case
case not <OC:Methanosarcinaceae>
FUNCTIONPart of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.
end case
case <OC:Methanosarcinaceae>
PATHWAYOne-carbon metabolism; methanogenesis from acetate.
end case
SUBUNITHeterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)- (gamma(1)delta(1))(8).
SIMILARITYBelongs to the CdhB family.

Keywords [?]

case <OC:Methanosarcinaceae>
Methanogenesis
end case

Gene Ontology [?]

case <OCellular component:Methanosarcinaceae>
GO:0019385; Biological process:methanogenesis, from acetate
end case

Cross-references [?]

Pfam PF02552; CO_dh; 1;
NCBIfam TIGR00315; CdhB; 1;

Features [?]


Additional information [?]

Size range 146-187 amino acids
Related rules None
Fusion Nter: None Cter: None



View rule in raw text format (no links)