HAMAP rule MF_01134
General rule information
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| Accession | MF_01134 |
| Dates | 20-NOV-2003 (Created) 1-JUN-2023 (Last updated, Version 14) |
| Name | CdhB |
| Scope | Archaea |
| Templates | Q9C4Z3 (ACDE2_METTE); Q46G05 (ACDE1_METBF): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Methanosarcinaceae>
| Function | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. |
end case
case not <OC:Methanosarcinaceae>
| Function | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. |
end case
case <OC:Methanosarcinaceae>
| Pathway | One-carbon metabolism; methanogenesis from acetate. |
end case
| Subunit | Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8). |
| Similarity | Belongs to the CdhB family. |
Keywords
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case <OC:Methanosarcinaceae>
end case
Gene Ontology
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case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case
Cross-references
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Additional information
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| Size range | 146-187 amino acids |
| Related rules | None |
| Fusion | None |