HAMAP rule MF_01134
General rule information
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| Accession | MF_01134 |
| Dates | 20-NOV-2003 (Created)
1-JUN-2023 (Last updated, Version 14) |
| Name | CdhB |
| Scope(s) |
Archaea |
| Template(s) | Q9C4Z3 (ACDE2_METTE); Q46G05 (ACDE1_METBF); [ Recover all ] |
| Triggered by |
HAMAP; MF_01134 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACDE |
| Protein name | RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit epsilon; Short=ACDS complex subunit epsilon; AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit epsilon; Short=ACDS CODH subunit epsilon; |
| Gene name | Name=cdhB; |
Comments
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| case <OC:Methanosarcinaceae> | |
| FUNCTION | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. |
| end case | |
| case not <OC:Methanosarcinaceae> | |
| FUNCTION | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation. |
| end case | |
| case <OC:Methanosarcinaceae> | |
| PATHWAY | One-carbon metabolism; methanogenesis from acetate. |
| end case | |
| SUBUNIT | Heterotetramer of two alpha and two epsilon subunits. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta subunits with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)- (gamma(1)delta(1))(8). |
| SIMILARITY | Belongs to the CdhB family. |
Keywords
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| case <OC:Methanosarcinaceae> | |
| Methanogenesis | |
| end case | |
Gene Ontology
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| case <OCellular component:Methanosarcinaceae> | |
| GO:0019385; Biological process:methanogenesis, from acetate | |
| end case | |
Cross-references
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Features
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Additional information
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| Size range | 146-187 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |