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HAMAP rule MF_01136

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General rule information [?]

Accession MF_01136
Dates 20-NOV-2003 (Created)
19-NOV-2022 (Last updated, Version 28)
Name CdhE
Template Q50539 (ACDG1_METTE)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma;
Short=ACDS complex subunit gamma;
AltName: Full=5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
AltName: Full=ACDS complex methyltransferase;
AltName: Full=Corrinoid/iron-sulfur component large subunit;
Gene name

Comments [?]

case <OC:Methanosarcinaceae>
Function Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
end case
case not <OC:Methanosarcinaceae>
Function Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
end case
Catalytic activity RHEA:45196: 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+)
Cofactor corrinoid
[4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster.
case <OC:Methanosarcinaceae>
Pathway One-carbon metabolism; methanogenesis from acetate.
end case
Subunit Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).

Keywords [?]

case <OC:Methanosarcinaceae>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function: iron ion binding.
end case
GO:0008168; Molecular function: methyltransferase activity.
case <OC:Methanosarcinaceae>
GO:0019385; Biological process: methanogenesis, from acetate.
end case

Cross-references [?]

Pfam PF03599; CdhD; 1;
PF04060; FeS; 1;
PROSITE PS51656; 4FE4S; 1; trigger=PRU00989;
PS00198; 4FE4S_FER_1; 1;

Features [?]

From: ACDG1_METTE (Q50539)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     18     18       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     21     21       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     26     26       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     43     43       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1

Additional information [?]

Size range 458-488 amino acids
Related rules None
Fusion None