HAMAP rule MF_01136
General rule information
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| Accession | MF_01136 |
| Dates | 20-NOV-2003 (Created)
19-NOV-2022 (Last updated, Version 28) |
| Name | CdhE |
| Scope(s) |
Archaea |
| Template(s) | Q50539 (ACDG1_METTE); [ Recover all ] |
| Triggered by |
HAMAP; MF_01136 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACDG |
| Protein name | RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma; Short=ACDS complex subunit gamma; EC=2.1.1.245; AltName: Full=5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase; AltName: Full=ACDS complex methyltransferase; AltName: Full=Corrinoid/iron-sulfur component large subunit; |
| Gene name | Name=cdhE; |
Comments
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| case <OC:Methanosarcinaceae> | |
| FUNCTION | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. |
| end case | |
| case not <OC:Methanosarcinaceae> | |
| FUNCTION | Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). |
| end case | |
| CATALYTIC ACTIVITY | Reaction=5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+); Xref=Rhea:RHEA:45196, Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, ChEBI:CHEBI:59924, ChEBI:CHEBI:64267, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.1.1.245; |
| COFACTOR | Name=corrinoid; Xref=ChEBI:CHEBI:33913; |
| COFACTOR | Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.; |
| case <OC:Methanosarcinaceae> | |
| PATHWAY | One-carbon metabolism; methanogenesis from acetate. |
| end case | |
| SUBUNIT | Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8). |
Keywords
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| case <OC:Methanosarcinaceae> | |
| Methanogenesis | |
| end case | |
| Transferase | |
| Methyltransferase | |
| case <FTGroup:1> | |
| Metal-binding | |
| Cobalt | |
| Iron | |
| Iron-sulfur | |
| 4Fe-4S | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0005506; Molecular function:iron ion binding | |
| end case | |
| GO:0008168; Molecular function:methyltransferase activity | |
| case <OCellular component:Methanosarcinaceae> | |
| GO:0019385; Biological process:methanogenesis, from acetate | |
| end case | |
Cross-references
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| Pfam | PF03599; CdhD; 1; |
| Pfam | PF04060; FeS; 1; |
| PROSITE | PS51656; 4FE4S; 1; |
| PROSITE | PS00198; 4FE4S_FER_1; 1; |
Features
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| From: ACDG1_METTE (Q50539) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 18 | 18 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 21 | 21 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 26 | 26 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
| BINDING | 43 | 43 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883" |
C | 1 | |||||||
Additional information
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| Size range | 458-488 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |