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HAMAP rule MF_01136

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General rule information [?]

Accession MF_01136
Dates 20-NOV-2003 (Created)
19-NOV-2022 (Last updated, Version 28)
Name CdhE
Scope(s) Archaea
Template(s) Q50539 (ACDG1_METTE); [ Recover all ]
Triggered by HAMAP; MF_01136 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACDG
Protein name RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma;
                 Short=ACDS complex subunit gamma;
AltName: Full=5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
AltName: Full=ACDS complex methyltransferase;
AltName: Full=Corrinoid/iron-sulfur component large subunit;
Gene name Name=cdhE;

Comments [?]

case <OC:Methanosarcinaceae>
FUNCTIONPart of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
end case
case not <OC:Methanosarcinaceae>
FUNCTIONPart of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
end case
CATALYTIC ACTIVITY Reaction=5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+); Xref=Rhea:RHEA:45196, Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, ChEBI:CHEBI:59924, ChEBI:CHEBI:64267, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=;
COFACTOR Name=corrinoid; Xref=ChEBI:CHEBI:33913;
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster.;
case <OC:Methanosarcinaceae>
PATHWAYOne-carbon metabolism; methanogenesis from acetate.
end case
SUBUNITHeterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).

Keywords [?]

case <OC:Methanosarcinaceae>
end case
case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
end case
GO:0008168; Molecular function:methyltransferase activity
case <OCellular component:Methanosarcinaceae>
GO:0019385; Biological process:methanogenesis, from acetate
end case

Cross-references [?]

Pfam PF03599; CdhD; 1;
Pfam PF04060; FeS; 1;
PROSITE PS51656; 4FE4S; 1;
PROSITE PS00198; 4FE4S_FER_1; 1;

Features [?]

From: ACDG1_METTE (Q50539)
Key From To Description Tag Condition FTGroup
BINDING 18 18 /ligand="[4Fe-4S] cluster"
C 1
BINDING 21 21 /ligand="[4Fe-4S] cluster"
C 1
BINDING 26 26 /ligand="[4Fe-4S] cluster"
C 1
BINDING 43 43 /ligand="[4Fe-4S] cluster"
C 1

Additional information [?]

Size range 458-488 amino acids
Related rules None
Fusion Nter: None Cter: None

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