HAMAP rule MF_01136

General rule information [?]

Accession	MF_01136
Dates	20-NOV-2003 (Created) 19-NOV-2022 (Last updated, Version 28)

Name

CdhE

Scope

Archaea

Template

Q50539 (ACDG1_METTE)

Triggered by

HAMAP; MF_01136 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ACDG

Protein name

RecName:		Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma;
		Short=ACDS complex subunit gamma;
		EC 2.1.1.245;
AltName:		Full=5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
AltName:		Full=ACDS complex methyltransferase;
AltName:		Full=Corrinoid/iron-sulfur component large subunit;

Gene name

cdhE

Comments [?]

case <OC:Methanosarcinaceae>

Function

Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.

end case

case not <OC:Methanosarcinaceae>

Function

Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).

end case

Catalytic activity	RHEA:45196: 5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid Fe-S protein] + H(+) EC 2.1.1.245
Cofactor	corrinoid
	[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster.

case <OC:Methanosarcinaceae>

Pathway

One-carbon metabolism; methanogenesis from acetate.

end case

Subunit

Heterodimer of delta and gamma chains. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).

Keywords [?]

case <OC:Methanosarcinaceae>

Methanogenesis

end case

Transferase
Methyltransferase

case <FTGroup:1>

Metal-binding
Cobalt
Iron
Iron-sulfur
4Fe-4S

end case

Gene Ontology [?]

case <FTGroup:1>

GO:0005506; Molecular function: iron ion binding.

end case

GO:0008168; Molecular function: methyltransferase activity.

case <OC:Methanosarcinaceae>

GO:0019385; Biological process: methanogenesis, from acetate.

end case

Cross-references [?]

Pfam	PF03599; CdhD; 1;
	PF04060; FeS; 1;
PROSITE	PS51656; 4FE4S; 1; trigger=PRU00989;
	PS00198; 4FE4S_FER_1; 1;

Features [?]

From: ACDG1_METTE (Q50539)

Key From To Description Tag Condition FTGroup

BINDING 18 18 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 21 21 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 26 26 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

BINDING 43 43 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C 1

Additional information [?]

Size range	458-488 amino acids
Related rules	None
Fusion	None

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