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HAMAP rule MF_01143

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General rule information [?]

Accession MF_01143
Dates 4-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 18)
Name CidA
Scope(s) Bacteria
Bacillales
Template(s) P60647 (CIDA_STAA8); [ Recover all ]
Triggered by HAMAP; MF_01143 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CIDA
Protein name RecName: Full=Holin-like protein CidA;
Gene name Name=cidA;

Comments [?]

case <OC:Staphylococcus>
FUNCTIONIncreases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential.
else
FUNCTIONIncreases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential.
end case
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the CidA/LrgA family. CidA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0019835; Biological process:cytolysis
GO:0012501; Biological process:programmed cell death
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF03788; LrgA; 1;
General Transmembrane; -; 4;

Features [?]


Additional information [?]

Size range 118-131 amino acids
Related rules None
Fusion Nter: None Cter: None



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