HAMAP rule MF_01143
General rule information
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| Accession | MF_01143 |
| Dates | 4-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 18) |
| Name | CidA |
| Scope(s) |
Bacteria Bacillales |
| Template(s) | P60647 (CIDA_STAA8); [ Recover all ] |
| Triggered by |
HAMAP; MF_01143 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | CIDA |
| Protein name | RecName: Full=Holin-like protein CidA; |
| Gene name | Name=cidA; |
Comments
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| case <OC:Staphylococcus> | |
| FUNCTION | Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential. |
| else | |
| FUNCTION | Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. When a cell is stressed by the addition of antibiotics or by other factors in the environment, CidA possibly oligomerizes within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypothesized to regulate the subsequent cell lysis by either allowing the murein hydrolases access to the cell wall substrate and/or regulating their activity by a possible change in the cell wall pH that results from loss of membrane potential. |
| end case | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the CidA/LrgA family. CidA subfamily. |
Keywords
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Gene Ontology
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| GO:0019835; Biological process:cytolysis |
| GO:0012501; Biological process:programmed cell death |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF03788; LrgA; 1; |
| General | Transmembrane; -; 4; |
Features
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Additional information
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| Size range | 118-131 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |