HAMAP rule MF_01145
General rule information
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| Accession | MF_01145 |
| Dates | 12-MAR-2004 (Created)
13-JAN-2023 (Last updated, Version 21) |
| Name | Foldase_PrsA |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | P24327 (PRSA_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01145 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PRSA |
| Protein name | RecName: Full=Foldase protein PrsA; EC=5.2.1.8; Flags: Precursor; |
| Gene name | Name=prsA; |
Comments
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| FUNCTION | Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. |
| CATALYTIC ACTIVITY | Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8; |
| case <Feature:PS51257> | |
| SUBCELLULAR LOCATION | Cell membrane; Lipid-anchor. |
| end case | |
| SIMILARITY | Belongs to the PrsA family. |
Keywords
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| Isomerase | |
| Rotamase | |
| Cell membrane | |
| Membrane | |
| case <Feature:PS51257> | |
| Lipoprotein | |
| Palmitate | |
| end case | |
| Signal | |
Gene Ontology
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| GO:0003755; Molecular function:peptidyl-prolyl cis-trans isomerase activity | |
| GO:0006457; Biological process:protein folding | |
| case <Feature:PS51257> | |
| GO:0005886; Cellular component:plasma membrane | |
| end case | |
Cross-references
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| Pfam | PF00639; Rotamase; 1; |
| PROSITE | PS01096; PPIC_PPIASE_1; 1; |
| PROSITE | PS50198; PPIC_PPIASE_2; 1; |
| PROSITE | PS51257; PROKAR_LIPOPROTEIN; 1; |
Features
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Additional information
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| Size range | 248-353 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | These proteins are typical of Gram-positive bacteria. They share low similarity and may be present in several copies per genome. Some do not possess the PPIase domain but are still active as foldases. |