Home  |  Contact
Annotation rule MF_01145
Send feedback

General rule information [?]

Accession MF_01145
Dates 12-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 20)
Name Foldase_PrsA
Scope
Bacteria; Firmicutes
Template P24327 (PRSA_BACSU)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PRSA
Protein name
RecName: Full=Foldase protein PrsA;
EC 5.2.1.8;
Flags: Precursor;
Gene name
prsA

Comments [?]

Function Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
Catalytic activity RHEA:16237: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
EC 5.2.1.8
case <Feature:PS51257>
Subcellular location Cell membrane; Lipid-anchor.
end case
Similarity Belongs to the PrsA family.

Keywords [?]

case <Feature:PS51257>
end case

Gene Ontology [?]

GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity.
GO:0006457; Biological process: protein folding.
case <Feature:PS51257>
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

Pfam PF00639; Rotamase; 1;
PROSITE PS01096; PPIC_PPIASE_1; 1;
PS50198; PPIC_PPIASE_2; 1; trigger=PRU00278;
PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303;

Additional information [?]

Size range 248-353 amino acids
Related rules None
Fusion None
Comments These proteins are typical of Gram-positive bacteria. They share low similarity and may be present in several copies per genome. Some do not possess the PPIase domain but are still active as foldases.