HAMAP rule MF_01145
General rule information
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| Accession | MF_01145 |
| Dates | 12-MAR-2004 (Created) 13-JAN-2023 (Last updated, Version 21) |
| Name | Foldase_PrsA |
| Scope | Bacteria; Bacillota |
| Template | P24327 (PRSA_BACSU) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins. |
| Catalytic activity | RHEA:16237: [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
EC 5.2.1.8 |
case <Feature:PS51257>
| Subcellular location | Cell membrane; Lipid-anchor. |
end case
| Similarity | Belongs to the PrsA family. |
Keywords
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case <Feature:PS51257>
end case
Gene Ontology
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GO:0003755; Molecular function: peptidyl-prolyl cis-trans isomerase activity.
GO:0006457; Biological process: protein folding.
GO:0006457; Biological process: protein folding.
case <Feature:PS51257>
GO:0005886; Cellular component: plasma membrane.
end case
Cross-references
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| Pfam | PF00639; Rotamase; 1; |
| PROSITE | PS01096; PPIC_PPIASE_1; 1; |
| PS50198; PPIC_PPIASE_2; 1; trigger=PRU00278; | |
| PS51257; PROKAR_LIPOPROTEIN; 1; trigger=PRU00303; |
Additional information
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| Size range | 248-353 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | These proteins are typical of Gram-positive bacteria. They share low similarity and may be present in several copies per genome. Some do not possess the PPIase domain but are still active as foldases. |