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HAMAP rule MF_01146

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General rule information [?]

Accession MF_01146
Dates 25-MAR-2004 (Created)
1-JUN-2023 (Last updated, Version 28)
Name Aquaporin_Z
Scope(s) Bacteria
Template(s) P60844 (AQPZ_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01146 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier AQPZ
Protein name RecName: Full=Aquaporin Z;
Gene name Name=aqpZ;

Comments [?]

FUNCTIONChannel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
CATALYTIC ACTIVITY Reaction=H2O(in) = H2O(out); Xref=Rhea:RHEA:29667, ChEBI:CHEBI:15377; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29668; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29669;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
case <FT:1> and <FT:2>
DOMAINAquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
end case
SIMILARITYBelongs to the MIP/aquaporin (TC 1.A.8) family.

Keywords [?]

Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <FT:1> and <FT:2>
end case
Transmembrane helix

Gene Ontology [?]

GO:0015250; Molecular function:water channel activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00230; MIP; 1;
NCBIfam TIGR00861; MIP; 1;
PROSITE PS00221; MIP; 1;
General Transmembrane; -; 6;

Features [?]

From: AQPZ_ECOLI (P60844)
Key From To Description Tag Condition FTGroup
MOTIF 63 65 /note="NPA 1" N-P-A
MOTIF 186 188 /note="NPA 2" N-P-A
SITE 20 20 /note="Involved in tetramerization or stability of the tetramer" C
SITE 43 43 /note="Selectivity filter" F
SITE 174 174 /note="Selectivity filter" H
SITE 183 183 /note="Selectivity filter" T
SITE 189 189 /note="Selectivity filter" R

Additional information [?]

Size range 170-248 amino acids
Related rules None
Fusion Nter: None Cter: None

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