Home  |  Contact
Annotation rule MF_01146
Send feedback

General rule information [?]

Accession MF_01146
Dates 25-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 26)
Name Aquaporin_Z
Scope
Bacteria
Template P60844 (AQPZ_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
AQPZ
Protein name
RecName: Full=Aquaporin Z;
Gene name
aqpZ

Comments [?]

Function Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Subunit Homotetramer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
case <FT:1> and <FT:2>
Domain Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
end case
Similarity Belongs to the MIP/aquaporin (TC 1.A.8) family.

Keywords [?]

Transport
Transmembrane
Cell membrane
Membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
case <FT:1> and <FT:2>
Repeat
end case
Transmembrane helix

Gene Ontology [?]

GO:0015250; Molecular function: water channel activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00230; MIP; 1;
PRINTS PR00783; MINTRINSICP; 1;
TIGRFAMs TIGR00861; MIP; 1;
PROSITE PS00221; MIP; 1;

Computed features [?]

General Transmembrane; -; 6; trigger=yes;

Features [?]

From: AQPZ_ECOLI (P60844)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     63     65       NPA 1     N-P-A  
MOTIF     186     188       NPA 2     N-P-A  
SITE     20     20       Involved in tetramerization or stability of the tetramer     C  
SITE (Optional)     43     43       Selectivity filter     F  
SITE (Optional)     174     174       Selectivity filter     H  
SITE (Optional)     183     183       Selectivity filter     T  
SITE (Optional)     189     189       Selectivity filter     R  

Additional information [?]

Size range 170-248 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)