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Annotation rule MF_01146 |
General rule information
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Accession |
MF_01146 |
Dates |
25-MAR-2004 (Created) 19-NOV-2019 (Last updated, Version 26) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Aquaporin Z;
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Function |
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. |
Subunit |
Homotetramer. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
case <FT:1> and <FT:2>
Domain |
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). |
end case
Similarity |
Belongs to the MIP/aquaporin (TC 1.A.8) family. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <FT:1> and <FT:2>
end case
GO:0015250; Molecular function: water channel activity.
GO:0005886; Cellular component: plasma membrane.
General |
Transmembrane; -; 6; trigger=yes; |
From: AQPZ_ECOLI (P60844) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOTIF
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63
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65
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NPA 1
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N-P-A
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MOTIF
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186
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188
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NPA 2
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N-P-A
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SITE
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20
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20
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Involved in tetramerization or stability of the tetramer
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C
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SITE (Optional)
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43
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43
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Selectivity filter
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F
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SITE (Optional)
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174
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174
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Selectivity filter
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H
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SITE (Optional)
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183
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183
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Selectivity filter
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T
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SITE (Optional)
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189
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189
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Selectivity filter
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R
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Additional information
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Size range |
170-248 amino acids |
Related rules |
None |
Fusion |
None |