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Annotation rule MF_01146
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General rule information [?]

Accession MF_01146
Dates 25-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 26)
Name Aquaporin_Z
Template P60844 (AQPZ_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Aquaporin Z;
Gene name

Comments [?]

Function Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Subunit Homotetramer.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
case <FT:1> and <FT:2>
Domain Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
end case
Similarity Belongs to the MIP/aquaporin (TC 1.A.8) family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case
case <FT:1> and <FT:2>
end case

Gene Ontology [?]

GO:0015250; Molecular function: water channel activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00230; MIP; 1;
PROSITE PS00221; MIP; 1;

Computed features [?]

General Transmembrane; -; 6; trigger=yes;

Features [?]

From: AQPZ_ECOLI (P60844)
Key     From     To       Description   Tag   Condition   FTGroup
MOTIF     63     65       NPA 1     N-P-A  
MOTIF     186     188       NPA 2     N-P-A  
SITE     20     20       Involved in tetramerization or stability of the tetramer     C  
SITE (Optional)     43     43       Selectivity filter     F  
SITE (Optional)     174     174       Selectivity filter     H  
SITE (Optional)     183     183       Selectivity filter     T  
SITE (Optional)     189     189       Selectivity filter     R  

Additional information [?]

Size range 170-248 amino acids
Related rules None
Fusion None