HAMAP rule MF_01146
General rule information
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| Accession | MF_01146 |
| Dates | 25-MAR-2004 (Created)
1-JUN-2023 (Last updated, Version 28) |
| Name | Aquaporin_Z |
| Scope(s) |
Bacteria |
| Template(s) | P60844 (AQPZ_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01146 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | AQPZ |
| Protein name | RecName: Full=Aquaporin Z; |
| Gene name | Name=aqpZ; |
Comments
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| FUNCTION | Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. |
| CATALYTIC ACTIVITY | Reaction=H2O(in) = H2O(out); Xref=Rhea:RHEA:29667, ChEBI:CHEBI:15377; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29668; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29669; |
| SUBUNIT | Homotetramer. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| case <FT:1> and <FT:2> | |
| DOMAIN | Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). |
| end case | |
| SIMILARITY | Belongs to the MIP/aquaporin (TC 1.A.8) family. |
Keywords
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| Transport | |
| Transmembrane | |
| Cell membrane | |
| Membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| case <FT:1> and <FT:2> | |
| Repeat | |
| end case | |
| Transmembrane helix | |
Gene Ontology
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| GO:0015250; Molecular function:water channel activity |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF00230; MIP; 1; |
| PRINTS | PR00783; MINTRINSICP; 1; |
| NCBIfam | TIGR00861; MIP; 1; |
| PROSITE | PS00221; MIP; 1; |
| General | Transmembrane; -; 6; |
Features
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| From: AQPZ_ECOLI (P60844) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOTIF | 63 | 65 | /note="NPA 1" | N-P-A | ||||||||
| MOTIF | 186 | 188 | /note="NPA 2" | N-P-A | ||||||||
| SITE | 20 | 20 | /note="Involved in tetramerization or stability of the tetramer" | C | ||||||||
| SITE | 43 | 43 | /note="Selectivity filter" | F | ||||||||
| SITE | 174 | 174 | /note="Selectivity filter" | H | ||||||||
| SITE | 183 | 183 | /note="Selectivity filter" | T | ||||||||
| SITE | 189 | 189 | /note="Selectivity filter" | R | ||||||||
Additional information
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| Size range | 170-248 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |