HAMAP rule MF_01147
General rule information
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Accession | MF_01147 |
Dates | 2-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 37) |
Name | Lgt |
Scope(s) |
Bacteria |
Template(s) | Q2G044 (LGT_STAA8); P60959 (LGT_SALTY); [ Recover all ] |
Triggered by |
HAMAP; MF_01147 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | LGT |
Protein name | RecName: Full=Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase; EC=2.5.1.145; |
Gene name | Name=lgt; |
Comments
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FUNCTION | Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. |
CATALYTIC ACTIVITY | Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L- cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L- cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate; Xref=Rhea:RHEA:56712, Rhea:RHEA-COMP:14679, Rhea:RHEA-COMP:14680, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:57685, ChEBI:CHEBI:64716, ChEBI:CHEBI:140658; EC=2.5.1.145; |
PATHWAY | Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the Lgt family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Cell membrane | |
Membrane | |
Transferase | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0008961; Molecular function:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity |
GO:0042158; Biological process:lipoprotein biosynthetic process |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF01790; LGT; 1; |
NCBIfam | TIGR00544; lgt; 1; |
PROSITE | PS01311; LGT; 1; |
General | Transmembrane; -; 5-9; |
Features
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From: LGT_ECOLI (P60955) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 143 | 143 | /ligand="1,2-diacyl-sn-glycero-3-phospho-(1'-sn- glycerol)" /ligand_id="ChEBI:CHEBI:64716" |
R |
Additional information
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Size range | 243-492 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |