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HAMAP rule MF_01147

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General rule information [?]

Accession MF_01147
Dates 2-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 37)
Name Lgt
Scope
Bacteria
Templates Q2G044 (LGT_STAA8); P60959 (LGT_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LGT
Protein name
RecName: Full=Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase;
EC 2.5.1.145;
Gene name
lgt

Comments [?]

Function Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Catalytic activity RHEA:56712: 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate
EC 2.5.1.145
Pathway Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the Lgt family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008961; Molecular function: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity.
GO:0042158; Biological process: lipoprotein biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF01790; LGT; 1;
NCBIfam TIGR00544; lgt; 1;
PROSITE PS01311; LGT; 1;

Computed features [?]

General Transmembrane; -; 5-9; trigger=yes;

Features [?]

From: LGT_ECOLI (P60955)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     143     143       /ligand="1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)" /ligand_id="ChEBI:CHEBI:64716     R  

Additional information [?]

Size range 243-492 amino acids
Related rules None
Fusion None


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