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HAMAP rule MF_01147

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General rule information [?]

Accession MF_01147
Dates 2-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 37)
Name Lgt
Scope(s) Bacteria
Template(s) Q2G044 (LGT_STAA8); P60959 (LGT_SALTY); [ Recover all ]
Triggered by HAMAP; MF_01147 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LGT
Protein name RecName: Full=Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase;
                 EC=2.5.1.145;
Gene name Name=lgt;

Comments [?]

FUNCTIONCatalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
CATALYTIC ACTIVITY Reaction=1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L- cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L- cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate; Xref=Rhea:RHEA:56712, Rhea:RHEA-COMP:14679, Rhea:RHEA-COMP:14680, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:57685, ChEBI:CHEBI:64716, ChEBI:CHEBI:140658; EC=2.5.1.145;
PATHWAYProtein modification; lipoprotein biosynthesis (diacylglyceryl transfer).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the Lgt family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0008961; Molecular function:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity
GO:0042158; Biological process:lipoprotein biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF01790; LGT; 1;
NCBIfam TIGR00544; lgt; 1;
PROSITE PS01311; LGT; 1;
General Transmembrane; -; 5-9;

Features [?]

From: LGT_ECOLI (P60955)
Key From To Description Tag Condition FTGroup
BINDING 143 143 /ligand="1,2-diacyl-sn-glycero-3-phospho-(1'-sn- glycerol)"
/ligand_id="ChEBI:CHEBI:64716"
R

Additional information [?]

Size range 243-492 amino acids
Related rules None
Fusion Nter: None Cter: None



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