HAMAP rule MF_01147
General rule information
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| Accession | MF_01147 |
| Dates | 2-APR-2004 (Created)
3-SEP-2024 (Last updated, Version 39) |
| Name | Lgt |
| Scope(s) |
Bacteria |
| Template(s) | Q2G044 (LGT_STAA8); P60959 (LGT_SALTY); [ Recover all ] |
| Triggered by |
HAMAP; MF_01147 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | LGT |
| Protein name | RecName: Full=Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase; EC=2.5.1.145; |
| Gene name | Name=lgt; |
Comments
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| FUNCTION | Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins. |
| CATALYTIC ACTIVITY | Reaction=L-cysteinyl-[prolipoprotein] + a 1,2-diacyl-sn-glycero-3- phospho-(1'-sn-glycerol) = an S-1,2-diacyl-sn-glyceryl-L-cysteinyl- [prolipoprotein] + sn-glycerol 1-phosphate + H(+); Xref=Rhea:RHEA:56712, Rhea:RHEA-COMP:14679, Rhea:RHEA-COMP:14680, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:57685, ChEBI:CHEBI:64716, ChEBI:CHEBI:140658; EC=2.5.1.145; |
| PATHWAY | Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the Lgt family. |
Keywords
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| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0008961; Molecular function:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity |
| GO:0042158; Biological process:lipoprotein biosynthetic process |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF01790; LGT; 1; |
| NCBIfam | TIGR00544; lgt; 1; |
| PROSITE | PS01311; LGT; 1; |
| General | Transmembrane; -; 5-9; |
Features
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| From: LGT_ECOLI (P60955) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 143 | 143 | /ligand="1,2-diacyl-sn-glycero-3-phospho-(1'-sn- glycerol)" /ligand_id="ChEBI:CHEBI:64716" |
R | ||||||||
Additional information
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| Size range | 243-492 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |