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HAMAP rule MF_01148

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General rule information [?]

Accession MF_01148
Dates 7-APR-2004 (Created)
1-JUN-2023 (Last updated, Version 25)
Name Lnt
Scope(s) Bacteria
Template(s) P23930 (LNT_ECOLI); Q8FJY4 (LNT_ECOL6); [ Recover all ]
Triggered by HAMAP; MF_01148 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier LNT
Protein name RecName: Full=Apolipoprotein N-acyltransferase;
                 Short=ALP N-acyltransferase;
Gene name Name=lnt;

Comments [?]

FUNCTIONCatalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
CATALYTIC ACTIVITY Reaction=a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L- cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]; Xref=Rhea:RHEA:48228, Rhea:RHEA-COMP:14681, Rhea:RHEA-COMP:14684, ChEBI:CHEBI:15378, ChEBI:CHEBI:136912, ChEBI:CHEBI:140656, ChEBI:CHEBI:140657, ChEBI:CHEBI:140660; EC=;
PATHWAYProtein modification; lipoprotein biosynthesis (N-acyl transfer).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.

Keywords [?]

Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0016410; Molecular function:N-acyltransferase activity
GO:0042158; Biological process:lipoprotein biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00795; CN_hydrolase; 1;
NCBIfam TIGR00546; Lnt; 1;
General Transmembrane; -; 6-8;

Features [?]

Additional information [?]

Size range 400-595 amino acids
Related rules None
Fusion Nter: None Cter: <PPM synthase>
Comments In some Mycobacteria present as a fusion protein with PPM synthase (M.tuberculosis and M.bovis).

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