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HAMAP rule MF_01148

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General rule information [?]

Accession MF_01148
Dates 7-APR-2004 (Created)
13-JAN-2023 (Last updated, Version 24)
Name Lnt
Scope
Bacteria
Templates P23930 (LNT_ECOLI); Q8FJY4 (LNT_ECOL6): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
LNT
Protein name
RecName: Full=Apolipoprotein N-acyltransferase;
Short=ALP N-acyltransferase;
EC 2.3.1.269;
Gene name
lnt

Comments [?]

Function Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Catalytic activity RHEA:48228: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
EC 2.3.1.269
Pathway Protein modification; lipoprotein biosynthesis (N-acyl transfer).
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.

Keywords [?]

Transferase
Acyltransferase
Transmembrane
Membrane
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0016410; Molecular function: N-acyltransferase activity.
GO:0042158; Biological process: lipoprotein biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF00795; CN_hydrolase; 1;
TIGRFAMs TIGR00546; Lnt; 1;
PROSITE PS50263; CN_HYDROLASE; 1; trigger=PRU00054;

Computed features [?]

General Transmembrane; -; 6-8; trigger=yes;

Additional information [?]

Size range 400-595 amino acids
Related rules None
Fusion Nter: None; Cter: <PPM synthase>
Comments In some Mycobacteria present as a fusion protein with PPM synthase (M.tuberculosis and M.bovis).


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