HAMAP rule MF_01148
General rule information
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Accession | MF_01148 |
Dates | 7-APR-2004 (Created) 13-JAN-2023 (Last updated, Version 24) |
Name | Lnt |
Scope | Bacteria |
Templates | P23930 (LNT_ECOLI); Q8FJY4 (LNT_ECOL6): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. |
Catalytic activity | RHEA:48228: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
EC 2.3.1.269 |
Pathway | Protein modification; lipoprotein biosynthesis (N-acyl transfer). |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0016410; Molecular function: N-acyltransferase activity.
GO:0042158; Biological process: lipoprotein biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
GO:0042158; Biological process: lipoprotein biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Pfam | PF00795; CN_hydrolase; 1; |
TIGRFAMs | TIGR00546; Lnt; 1; |
PROSITE | PS50263; CN_HYDROLASE; 1; trigger=PRU00054; |
Computed features
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General | Transmembrane; -; 6-8; trigger=yes; |
Additional information
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Size range | 400-595 amino acids |
Related rules | None |
Fusion | Nter: None; Cter: <PPM synthase> |
Comments | In some Mycobacteria present as a fusion protein with PPM synthase (M.tuberculosis and M.bovis). |