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Annotation rule MF_01148 |
General rule information
[?]
Accession |
MF_01148 |
Dates |
7-APR-2004 (Created) 18-MAY-2021 (Last updated, Version 23) |
Propagated annotation
[?]
Identifier, protein and gene names
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Protein name |
RecName:
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Full=Apolipoprotein N-acyltransferase;
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Short=ALP N-acyltransferase;
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EC 2.3.1.269;
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Function |
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation. |
Catalytic activity |
RHEA:48228: a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]
EC 2.3.1.269
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Pathway |
Protein modification; lipoprotein biosynthesis (N-acyl transfer). |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity |
Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0016410; Molecular function: N-acyltransferase activity.
GO:0042158; Biological process: lipoprotein biosynthetic process.
GO:0005886; Cellular component: plasma membrane.
General |
Transmembrane; -; 6-8; trigger=yes; |
Additional information
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Size range |
400-595 amino acids |
Related rules |
None |
Fusion |
Nter: None; Cter: <PPM synthase> |
Comments |
In some Mycobacteria present as a fusion protein with PPM synthase (M.tuberculosis and M.bovis). |