HAMAP rule MF_01148

General rule information [?]

Accession	MF_01148
Dates	7-APR-2004 (Created) 1-JUN-2023 (Last updated, Version 25)
Name	Lnt
Scope(s)	Bacteria
Template(s)	P23930 (LNT_ECOLI); Q8FJY4 (LNT_ECOL6); [ Recover all ]
Triggered by	HAMAP; MF_01148 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	LNT
Protein name	RecName: Full=Apolipoprotein N-acyltransferase; Short=ALP N-acyltransferase; EC=2.3.1.269;
Gene name	Name=lnt;

Comments [?]

FUNCTION	Catalyzes the phospholipid dependent N-acylation of the N- terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
CATALYTIC ACTIVITY	Reaction=a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L- cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]; Xref=Rhea:RHEA:48228, Rhea:RHEA-COMP:14681, Rhea:RHEA-COMP:14684, ChEBI:CHEBI:15378, ChEBI:CHEBI:136912, ChEBI:CHEBI:140656, ChEBI:CHEBI:140657, ChEBI:CHEBI:140660; EC=2.3.1.269;
PATHWAY	Protein modification; lipoprotein biosynthesis (N-acyl transfer).
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the CN hydrolase family. Apolipoprotein N- acyltransferase subfamily.

Keywords [?]

Transferase
Acyltransferase
Transmembrane
Membrane
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0016410; Molecular function:N-acyltransferase activity

GO:0042158; Biological process:lipoprotein biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]

Size range	400-595 amino acids
Related rules	None
Fusion	Nter: None Cter: <PPM synthase>
Comments	In some Mycobacteria present as a fusion protein with PPM synthase (M.tuberculosis and M.bovis).