HAMAP rule MF_01158
General rule information
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| Accession | MF_01158 |
| Dates | 17-DEC-2004 (Created)
1-JUN-2023 (Last updated, Version 17) |
| Name | Hda |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P69931 (HDA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01158 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | HDA |
| Protein name | RecName: Full=DnaA regulatory inactivator Hda; |
| Gene name | Name=hda; |
Comments
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| FUNCTION | Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA. |
| SUBUNIT | The active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN). |
| SIMILARITY | Belongs to the DnaA family. HdA subfamily. |
Keywords
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Gene Ontology
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| GO:0006260; Biological process:DNA replication |
Cross-references
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Features
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Additional information
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| Size range | 225-248 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | In E.coli this has been shown to be initiated from a CUG start codon (PubMed:18977760), the first CUG start codon found in E.coli, which as it is inefficiently used probably keeps the protein levels low. We have propagated this same start site to other Escherichia and Shigella species but no further. |