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HAMAP rule MF_01158

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General rule information [?]

Accession MF_01158
Dates 17-DEC-2004 (Created)
1-JUN-2023 (Last updated, Version 17)
Name Hda
Bacteria; Enterobacterales
Template P69931 (HDA_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=DnaA regulatory inactivator Hda;
Gene name

Comments [?]

Function Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA.
Subunit The active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
Similarity Belongs to the DnaA family. HdA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0006260; Biological process: DNA replication.

Cross-references [?]

PRINTS PR00051; DNAA; 1;
NCBIfam TIGR03420; DnaA_homol_Hda; 1;

Additional information [?]

Size range 225-248 amino acids
Related rules None
Fusion None
Comments In E.coli this has been shown to be initiated from a CUG start codon (PubMed:18977760), the first CUG start codon found in E.coli, which as it is inefficiently used probably keeps the protein levels low. We have propagated this same start site to other Escherichia and Shigella species but no further.