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HAMAP rule MF_01158

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General rule information [?]

Accession MF_01158
Dates 17-DEC-2004 (Created)
1-JUN-2023 (Last updated, Version 17)
Name Hda
Scope(s) Bacteria
Template(s) P69931 (HDA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01158 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier HDA
Protein name RecName: Full=DnaA regulatory inactivator Hda;
Gene name Name=hda;

Comments [?]

FUNCTIONMediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA.
SUBUNITThe active form seems to be an ADP-bound monomer. Forms the RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and the DNA-loaded beta sliding clamp (dnaN).
SIMILARITYBelongs to the DnaA family. HdA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0006260; Biological process:DNA replication

Cross-references [?]

PRINTS PR00051; DNAA; 1;
NCBIfam TIGR03420; DnaA_homol_Hda; 1;

Features [?]

Additional information [?]

Size range 225-248 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments In E.coli this has been shown to be initiated from a CUG start codon (PubMed:18977760), the first CUG start codon found in E.coli, which as it is inefficiently used probably keeps the protein levels low. We have propagated this same start site to other Escherichia and Shigella species but no further.

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