HAMAP rule MF_01159
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01159 |
| Accession | MF_01159 |
| Dates | 28-FEB-2005 (Created)
21-NOV-2024 (Last updated, Version 13) |
| Name | YabA |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | P37542; [ Recover all ] |
| Triggered by |
HAMAP; MF_01159 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | YABA |
| Protein name | RecName: Full=Replication initiation control protein YabA; |
| Gene name | Name=yabA; |
Comments
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| FUNCTION | Involved in control of chromosome replication initiation. Inhibits the cooperative binding of DnaA to the oriC region, thus negatively regulating initiation of chromosome replication. Inhibits the ability of DnaA-ATP to form a helix on DNA; does not disassemble preformed DnaA-DNA helices. Decreases the residence time of DnaA on the chromosome at its binding sites (oriC, replication forks and promoter- binding sites). Tethers DnaA to the replication machinery via the DNA polymerase beta sliding clamp subunit (dnaN). Associates with oriC and other DnaA targets on the chromosome in a DnaA-dependent manner. |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| SUBUNIT | Homotetramer. Interacts with both DnaA and DnaN, acting as a bridge between these two proteins. |
| SUBCELLULAR LOCATION | Cytoplasm, nucleoid. Note=Localizes in tight foci, which correspond to the replisome at mid-cell throughout the cell cycle. |
| SIMILARITY | Belongs to the YabA family. |
Keywords
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| Cytoplasm | |
| DNA replication | |
| DNA replication inhibitor | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
Gene Ontology
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| GO:0008156; Biological process:negative regulation of DNA replication | |
| GO:0043590; Cellular component:bacterial nucleoid | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
Cross-references
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| Pfam | PF06156; DUF972; 1; |
| PIRSF | PIRSF021439; DUF972; 1; |
Features
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| From: YABA_BACSU (P37542) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 95 | 95 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | 1 | |||||||
| BINDING | 97 | 97 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 109 | 109 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 112 | 112 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 105-129 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |