HAMAP logo

HAMAP rule MF_01163

Send feedback

General rule information [?]

Accession MF_01163
Dates 11-APR-2005 (Created)
19-NOV-2022 (Last updated, Version 21)
Name IMP_biosynth_PurP
Scope
Archaea
Templates Q57600 (PURP_METJA); Q8U0R7 (PURP_PYRFU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PURP
Protein name
RecName: Full=5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase;
EC 6.3.4.23;
AltName: Full=5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase;
Gene name
purP

Comments [?]

Function Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
Catalytic activity RHEA:24836: 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
EC 6.3.4.23
Pathway Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1.
Similarity Belongs to the phosphohexose mutase family.

Keywords [?]

ATP-binding
Ligase
Nucleotide-binding
Purine biosynthesis

Gene Ontology [?]

GO:0016879; Molecular function: ligase activity, forming carbon-nitrogen bonds.
GO:0006189; Biological process: 'de novo' IMP biosynthetic process.

Cross-references [?]

Pfam PF06849; DUF1246; 1;
PF06973; DUF1297; 1;
PROSITE PS50975; ATP_GRASP; 1; trigger=PRU00409;

Features [?]

From: PURP_PYRFU (Q8U0R7)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     204     204       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     E  
BINDING     11     11       /ligand="5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide" /ligand_id="ChEBI:CHEBI:58475     H  
BINDING     71     71       /ligand="5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide" /ligand_id="ChEBI:CHEBI:58475     [ST]  
BINDING     232     232       /ligand="5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide" /ligand_id="ChEBI:CHEBI:58475     N  

Additional information [?]

Size range 330-377 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)