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HAMAP rule MF_01163

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General rule information [?]

Accession MF_01163
Dates 11-APR-2005 (Created)
19-NOV-2022 (Last updated, Version 21)
Name IMP_biosynth_PurP
Scope(s) Archaea
Template(s) Q57600 (PURP_METJA); Q8U0R7 (PURP_PYRFU); [ Recover all ]
Triggered by HAMAP; MF_01163 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PURP
Protein name RecName: Full=5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase;
AltName: Full=5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase;
Gene name Name=purP;

Comments [?]

FUNCTIONCatalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
CATALYTIC ACTIVITY Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide + ADP + phosphate; Xref=Rhea:RHEA:24836, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:456216; EC=;
PATHWAYPurine metabolism; IMP biosynthesis via de novo pathway; 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1.
SIMILARITYBelongs to the phosphohexose mutase family.

Keywords [?]

Gene Ontology [?]

GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds
GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Pfam PF06849; DUF1246; 1;
Pfam PF06973; DUF1297; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 204 204 /ligand="ATP"
BINDING 11 11 /ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide"
BINDING 71 71 /ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide"
BINDING 232 232 /ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide"

Additional information [?]

Size range 330-377 amino acids
Related rules None
Fusion Nter: None Cter: None

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