Due to maintenance work, this service will be unavailable from Mon Nov 11 17:30 until Tue Nov 12 09:00 CET. Apologies for the inconvenience.

HAMAP rule MF_01163

General rule information [?]

Accession	MF_01163
Dates	11-APR-2005 (Created) 19-NOV-2022 (Last updated, Version 21)
Name	IMP_biosynth_PurP
Scope(s)	Archaea
Template(s)	Q57600 (PURP_METJA); Q8U0R7 (PURP_PYRFU); [ Recover all ]
Triggered by	HAMAP; MF_01163 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	PURP
Protein name	RecName: Full=5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase; EC=6.3.4.23; AltName: Full=5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase;
Gene name	Name=purP;

Comments [?]

FUNCTION	Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
CATALYTIC ACTIVITY	Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4- carboxamide + ADP + phosphate; Xref=Rhea:RHEA:24836, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:456216; EC=6.3.4.23;
PATHWAY	Purine metabolism; IMP biosynthesis via de novo pathway; 5- formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino- 1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step 1/1.
SIMILARITY	Belongs to the phosphohexose mutase family.

Keywords [?]

Gene Ontology [?]

GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds

GO:0006189; Biological process:'de novo' IMP biosynthetic process

Cross-references [?]

Features [?]

From: PURP_PYRFU (Q8U0R7)

Key

From

Description

Tag

Condition

FTGroup

BINDING

204

/ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"

BINDING

/ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide"
/ligand_id="ChEBI:CHEBI:58475"

BINDING

/ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide"
/ligand_id="ChEBI:CHEBI:58475"

[ST]

BINDING

232

/ligand="5-amino-1-(5-phospho-beta-D- ribosyl)imidazole-4-carboxamide"
/ligand_id="ChEBI:CHEBI:58475"

Additional information [?]