HAMAP rule MF_01164

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01164
Accession	MF_01164
Dates	27-MAY-2005 (Created) 3-SEP-2024 (Last updated, Version 37)
Name	ArnC_transfer
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P77757 (ARNC_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01164 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ARNC
Protein name	RecName: Full=Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase; EC=2.4.2.53; AltName: Full=Undecaprenyl-phosphate Ara4FN transferase; Short=Ara4FN transferase;
Gene name	Name=arnC;

Comments [?]

FUNCTION	Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
CATALYTIC ACTIVITY	Reaction=UDP-4-deoxy-4-formamido-beta-L-arabinose + di-trans,octa-cis- undecaprenyl phosphate = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP; Xref=Rhea:RHEA:27722, ChEBI:CHEBI:58223, ChEBI:CHEBI:58709, ChEBI:CHEBI:58909, ChEBI:CHEBI:60392; EC=2.4.2.53;
PATHWAY	Glycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2.
PATHWAY	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the glycosyltransferase 2 family.

Keywords [?]

Antibiotic resistance
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Glycosyltransferase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups

GO:0009245; Biological process:lipid A biosynthetic process

GO:0009103; Biological process:lipopolysaccharide biosynthetic process

GO:0036108; Biological process:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

Additional information [?]