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HAMAP rule MF_01164

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General rule information [?]

Accession MF_01164
Dates 27-MAY-2005 (Created)
1-MAR-2024 (Last updated, Version 35)
Name ArnC_transfer
Scope(s) Bacteria
Gammaproteobacteria
Template(s) P77757 (ARNC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01164 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARNC
Protein name RecName: Full=Undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinose transferase;
                 EC=2.4.2.53;
AltName: Full=Undecaprenyl-phosphate Ara4FN transferase;
                 Short=Ara4FN transferase;
Gene name Name=arnC;

Comments [?]

FUNCTIONCatalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
CATALYTIC ACTIVITY Reaction=di-trans,octa-cis-undecaprenyl phosphate + UDP-4-deoxy-4- formamido-beta-L-arabinose = 4-deoxy-4-formamido-alpha-L- arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP; Xref=Rhea:RHEA:27722, ChEBI:CHEBI:58223, ChEBI:CHEBI:58709, ChEBI:CHEBI:58909, ChEBI:CHEBI:60392; EC=2.4.2.53;
PATHWAYGlycolipid biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate biosynthesis; 4-amino-4-deoxy-alpha-L-arabinose undecaprenyl phosphate from UDP-4-deoxy-4-formamido-beta-L-arabinose and undecaprenyl phosphate: step 1/2.
PATHWAYBacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the glycosyltransferase 2 family.

Keywords [?]


Gene Ontology [?]

GO:0016780; Molecular function:phosphotransferase activity, for other substituted phosphate groups
GO:0009245; Biological process:lipid A biosynthetic process
GO:0009103; Biological process:lipopolysaccharide biosynthetic process
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF00535; Glycos_transf_2; 1;
General Transmembrane; -; 2;
ADD_TOPO_DOMAIN Cytoplasmic; -; 2;
ADD_TOPO_DOMAIN Periplasmic; -; 1;
General Transmembrane; -; 2;

Features [?]


Additional information [?]

Size range 322-341 amino acids
Related rules None
Fusion Nter: None Cter: None



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