HAMAP rule MF_01165

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01165
Accession	MF_01165
Dates	16-JUN-2005 (Created) 28-APR-2022 (Last updated, Version 32)
Name	ArnT_transfer
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P76473; O52327; [ Recover all ]
Triggered by	HAMAP; MF_01165 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ARNT
Protein name	RecName: Full=Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase; EC=2.4.2.43; AltName: Full=4-amino-4-deoxy-L-arabinose lipid A transferase; AltName: Full=Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase; AltName: Full=Undecaprenyl phosphate-alpha-L-Ara4N transferase;
Gene name	Name=arnT;

Comments [?]

FUNCTION	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
CATALYTIC ACTIVITY	Reaction=4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis- undecaprenyl phosphate + lipid IVA = lipid IIA + di-trans,octa-cis- undecaprenyl phosphate.; EC=2.4.2.43;
PATHWAY	Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L- arabinose-lipid A biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the glycosyltransferase 83 family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Glycosyltransferase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity

GO:0009245; Biological process:lipid A biosynthetic process

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF02366; PMT; 1;
General	Transmembrane; -; 10-13;

Features [?]

Additional information [?]