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HAMAP rule MF_01165

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General rule information [?]

Accession MF_01165
Dates 16-JUN-2005 (Created)
28-APR-2022 (Last updated, Version 31)
Name ArnT_transfer
Scope
Bacteria; Gammaproteobacteria
Templates P76473 (ARNT_ECOLI); O52327 (ARNT_SALTY): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ARNT
Protein name
RecName: Full=Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase;
EC 2.4.2.43;
AltName: Full=4-amino-4-deoxy-L-arabinose lipid A transferase;
AltName: Full=Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase;
AltName: Full=Undecaprenyl phosphate-alpha-L-Ara4N transferase;
Gene name
arnT

Comments [?]

Function Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
Catalytic activity Reaction=4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IVA = lipid IIA + di-trans,octa-cis-undecaprenyl phosphate.; EC=2.4.2.43;
Pathway Lipopolysaccharide metabolism; 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the glycosyltransferase 83 family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Glycosyltransferase
Lipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
Lipopolysaccharide biosynthesis
Membrane
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0016740; Molecular function: transferase activity.
GO:0009245; Biological process: lipid A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF02366; PMT; 1;

Computed features [?]

General Transmembrane; -; 10-13; trigger=yes;

Additional information [?]

Size range 533-583 amino acids
Related rules None
Fusion None


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