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HAMAP rule MF_01167

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General rule information [?]

Accession MF_01167
Dates 11-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 27)
Name ArnB_transfer
Scope(s) Bacteria
Template(s) Q8ZNF3 (ARNB_SALTY); P77690 (ARNB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01167 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ARNB
Protein name RecName: Full=UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase;
AltName: Full=UDP-4-amino-4-deoxy-L-arabinose aminotransferase;
AltName: Full=UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase;
                 Short=UDP-Ara4O aminotransferase;
Gene name Name=arnB;

Comments [?]

FUNCTIONCatalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.
CATALYTIC ACTIVITY Reaction=2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L- glutamate + UDP-beta-L-threo-pentopyranos-4-ulose; Xref=Rhea:RHEA:24710, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:58708, ChEBI:CHEBI:58710; EC=;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYNucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3.
PATHWAYBacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
SIMILARITYBelongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008483; Molecular function:transaminase activity
GO:0046493; Biological process:lipid A metabolic process

Cross-references [?]

Pfam PF01041; DegT_DnrJ_EryC1; 1;
PIRSF PIRSF000390; PLP_StrS; 1;

Features [?]

Key From To Description Tag Condition FTGroup
MOD_RES 188 188 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 378-388 amino acids
Related rules None
Fusion Nter: None Cter: None

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