HAMAP rule MF_01167
General rule information
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| Accession | MF_01167 |
| Dates | 11-NOV-2005 (Created)
3-SEP-2024 (Last updated, Version 29) |
| Name | ArnB_transfer |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | Q8ZNF3 (ARNB_SALTY); P77690 (ARNB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01167 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ARNB |
| Protein name | RecName: Full=UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase; EC=2.6.1.87; AltName: Full=UDP-4-amino-4-deoxy-L-arabinose aminotransferase; AltName: Full=UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase; Short=UDP-Ara4O aminotransferase; |
| Gene name | Name=arnB; |
Comments
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| FUNCTION | Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. |
| CATALYTIC ACTIVITY | Reaction=UDP-4-amino-4-deoxy-beta-L-arabinose + 2-oxoglutarate = UDP- beta-L-threo-pentopyranos-4-ulose + L-glutamate; Xref=Rhea:RHEA:24710, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:58708, ChEBI:CHEBI:58710; EC=2.6.1.87; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L- arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from UDP-alpha-D-glucuronate: step 2/3. |
| PATHWAY | Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. |
Keywords
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| Aminotransferase |
| Antibiotic resistance |
| Lipid A biosynthesis |
| Lipid biosynthesis |
| Lipid metabolism |
| Lipopolysaccharide biosynthesis |
| Pyridoxal phosphate |
| Transferase |
Gene Ontology
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| GO:0008483; Molecular function:transaminase activity |
| GO:0046493; Biological process:lipid A metabolic process |
| GO:0009103; Biological process:lipopolysaccharide biosynthetic process |
Cross-references
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| Pfam | PF01041; DegT_DnrJ_EryC1; 1; |
| PIRSF | PIRSF000390; PLP_StrS; 1; |
Features
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| From: ARNB_SALTY (Q8ZNF3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 188 | 188 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 378-388 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |