HAMAP rule MF_01169

General rule information [?]

Accession	MF_01169
Dates	17-DEC-2005 (Created) 1-JUN-2023 (Last updated, Version 16)
Name	SucA_OdhA
Scope(s)	Bacteria Bacillales Brucellaceae Leptospiraceae
Template(s)	P23129 (ODO1_BACSU); [ Recover all ]
Triggered by	HAMAP; MF_01169 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ODO1
Protein name	RecName: Full=2-oxoglutarate dehydrogenase E1 component; EC=1.2.4.2; AltName: Full=Alpha-ketoglutarate dehydrogenase;
case <OC:Bacillota>
Gene name	Name=odhA;
end case
case not <OC:Bacillota>
Gene name	Name=sucA; Synonyms=odhA;
end case

Comments [?]

FUNCTION	E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
CATALYTIC ACTIVITY	Reaction=(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H(+) = (R)-N(6)-(S(8)- succinyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2; Xref=Rhea:RHEA:12188, Rhea:RHEA- COMP:10483, Rhea:RHEA-COMP:10484, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:83099, ChEBI:CHEBI:83120; EC=1.2.4.2;
COFACTOR	Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
SUBUNIT	Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).
SIMILARITY	Belongs to the alpha-ketoglutarate dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0004591; Molecular function:oxoglutarate dehydrogenase (succinyl-transferring) activity

GO:0030976; Molecular function:thiamine pyrophosphate binding

GO:0006096; Biological process:glycolytic process

Cross-references [?]

Features [?]

Additional information [?]

Size range	910-1004 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	This family is restricted taxonomically to some bacteria so as to avoid overlap with proteins that have similarity to alpha-ketoglutarate dehydrogenase but may be a different enzyme.