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Annotation rule MF_01169
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General rule information [?]

Accession MF_01169
Dates 17-DEC-2005 (Created)
19-NOV-2019 (Last updated, Version 13)
Name SucA_OdhA
Bacteria; Bacillales
Bacteria; Brucellaceae
Bacteria; Leptospiraceae
Template P23129 (ODO1_BACSU)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=2-oxoglutarate dehydrogenase E1 component;
AltName: Full=Alpha-ketoglutarate dehydrogenase;
case <OC:Firmicutes>
Gene name
end case
case not <OC:Firmicutes>
Gene name
sucA, odhA
end case

Comments [?]

Function E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
Catalytic activity RHEA:12188: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2
Cofactor thiamine diphosphate
Subunit Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).
Similarity Belongs to the alpha-ketoglutarate dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0004591; Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity.
GO:0030976; Molecular function: thiamine pyrophosphate binding.
GO:0006096; Biological process: glycolytic process.

Cross-references [?]

Pfam PF00676; E1_dh; 1;
PF02779; Transket_pyr; 1;
TIGRFAMs TIGR00239; 2oxo_dh_E1; 1;

Additional information [?]

Size range 910-1004 amino acids
Related rules None
Fusion None
Comments This family is restricted taxonomically to some bacteria so as to avoid overlap with proteins that have similarity to alpha-ketoglutarate dehydrogenase but may be a different enzyme.