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Annotation rule MF_01169 |
Accession | MF_01169 |
Dates | 17-DEC-2005 (Created) 19-NOV-2019 (Last updated, Version 13) |
Name | SucA_OdhA |
Scope | Bacteria; Bacillales
Bacteria; Brucellaceae
Bacteria; Leptospiraceae |
Template | P23129 (ODO1_BACSU) |
Triggered by |
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Function | E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). |
Catalytic activity | RHEA:12188: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue succinyltransferase]-(R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysine + CO2
EC 1.2.4.2 |
Cofactor | thiamine diphosphate |
Subunit | Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3). |
Similarity | Belongs to the alpha-ketoglutarate dehydrogenase family. |
Size range | 910-1004 amino acids |
Related rules | None |
Fusion | None |
Comments | This family is restricted taxonomically to some bacteria so as to avoid overlap with proteins that have similarity to alpha-ketoglutarate dehydrogenase but may be a different enzyme. |