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HAMAP rule MF_01169

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General rule information [?]

Accession MF_01169
Dates 17-DEC-2005 (Created)
14-SEP-2023 (Last updated, Version 17)
Name SucA_OdhA
Scope(s) Bacteria
Template(s) P23129 (ODO1_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01169 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ODO1
Protein name RecName: Full=2-oxoglutarate dehydrogenase E1 component;
AltName: Full=Alpha-ketoglutarate dehydrogenase;
case <OC:Bacillota>
Gene name Name=odhA;
end case
case not <OC:Bacillota>
Gene name Name=sucA; Synonyms=odhA;
end case

Comments [?]

FUNCTIONE1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
CATALYTIC ACTIVITY Reaction=2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl- [dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)- S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase]; Xref=Rhea:RHEA:12188, Rhea:RHEA-COMP:10483, Rhea:RHEA-COMP:10484, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:83099, ChEBI:CHEBI:83120; EC=;
COFACTOR Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
SUBUNITHomodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3).
SIMILARITYBelongs to the alpha-ketoglutarate dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0004591; Molecular function:oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0030976; Molecular function:thiamine pyrophosphate binding
GO:0006096; Biological process:glycolytic process

Cross-references [?]

Pfam PF00676; E1_dh; 1;
Pfam PF02779; Transket_pyr; 1;
NCBIfam TIGR00239; 2oxo_dh_E1; 1;

Features [?]

Additional information [?]

Size range 910-1004 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments This family is restricted taxonomically to some bacteria so as to avoid overlap with proteins that have similarity to alpha-ketoglutarate dehydrogenase but may be a different enzyme.

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