HAMAP rule MF_01176
General rule information
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Accession | MF_01176 |
Dates | 23-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24) |
Name | HTH_type_IscR |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P0AGK8 (ISCR_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01176 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | ISCR |
Protein name | RecName: Full=HTH-type transcriptional regulator IscR; |
Gene name | Name=iscR; |
Comments
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FUNCTION | Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. |
case <FTGroup:1> | |
COFACTOR | Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.; |
end case |
Keywords
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case <FTGroup:1> | |
2Fe-2S | |
end case | |
Activator | |
DNA-binding | |
case <FTGroup:1> | |
Iron | |
Iron-sulfur | |
Metal-binding | |
end case | |
Repressor | |
Transcription | |
Transcription regulation |
Gene Ontology
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GO:0003690; Molecular function:double-stranded DNA binding | |
case <FTGroup:1> | |
GO:0005506; Molecular function:iron ion binding | |
end case | |
GO:0003700; Molecular function:DNA-binding transcription factor activity | |
GO:0006355; Biological process:regulation of DNA-templated transcription |
Cross-references
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PROSITE | PS01332; HTH_RRF2_1; 1; |
PROSITE | PS51197; HTH_RRF2_2; 1; |
Pfam | PF02082; Rrf2; 1; |
NCBIfam | TIGR02010; IscR; 1; |
NCBIfam | TIGR00738; Rrf2_super; 1; |
Features
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From: ISCR_ECOLI (P0AGK8) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 92 | 92 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 98 | 98 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
BINDING | 104 | 104 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 |
Additional information
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Size range | 162-173 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |