HAMAP rule MF_01176
General rule information
[?]
| Accession | MF_01176 |
| Dates | 23-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 24) |
| Name | HTH_type_IscR |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P0AGK8 (ISCR_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01176 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | ISCR |
| Protein name | RecName: Full=HTH-type transcriptional regulator IscR; |
| Gene name | Name=iscR; |
Comments
[?]
| FUNCTION | Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. |
| case <FTGroup:1> | |
| COFACTOR | Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135; Note=Binds 1 [2Fe-2S] cluster.; |
| end case | |
Keywords
[?]
| case <FTGroup:1> | |
| 2Fe-2S | |
| end case | |
| Activator | |
| DNA-binding | |
| case <FTGroup:1> | |
| Iron | |
| Iron-sulfur | |
| Metal-binding | |
| end case | |
| Repressor | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
[?]
| GO:0003690; Molecular function:double-stranded DNA binding | |
| case <FTGroup:1> | |
| GO:0005506; Molecular function:iron ion binding | |
| end case | |
| GO:0003700; Molecular function:DNA-binding transcription factor activity | |
| GO:0006355; Biological process:regulation of DNA-templated transcription | |
Cross-references
[?]
| PROSITE | PS01332; HTH_RRF2_1; 1; |
| PROSITE | PS51197; HTH_RRF2_2; 1; |
| Pfam | PF02082; Rrf2; 1; |
| NCBIfam | TIGR02010; IscR; 1; |
| NCBIfam | TIGR00738; Rrf2_super; 1; |
Features
[?]
| From: ISCR_ECOLI (P0AGK8) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 92 | 92 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
| BINDING | 98 | 98 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
| BINDING | 104 | 104 | /ligand="[2Fe-2S] cluster" /ligand_id="ChEBI:CHEBI:190135" |
C | 1 | |||||||
Additional information
[?]
| Size range | 162-173 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |