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HAMAP rule MF_01179

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General rule information [?]

Accession MF_01179
Dates 15-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 14)
Name SulA
Scope(s) Bacteria
Template(s) P0AFZ5 (SULA_ECOLI); Q9HZJ8 (SULA_PSEAE); [ Recover all ]
Triggered by HAMAP; MF_01179 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SULA
Protein name RecName: Full=Cell division inhibitor SulA;
Gene name Name=sulA;

Comments [?]

FUNCTIONComponent of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
SUBUNITInteracts with FtsZ.
INDUCTIONBy DNA damage, as part of the SOS response.
PTMIs rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.
SIMILARITYBelongs to the SulA family.

Keywords [?]

Gene Ontology [?]

GO:0051782; Biological process:negative regulation of cell division
GO:0006974; Biological process:DNA damage response
GO:0009432; Biological process:SOS response

Cross-references [?]

Pfam PF03846; SulA; 1;
NCBIfam TIGR00623; Sula; 1;

Features [?]

Key From To Description Tag Condition FTGroup
REGION 106 112 /note="FtsZ binding" A-L-x-[TS]-G-N-Y
REGION 162 169 /note="Lon protease binding" [KR]-I-H-S-x-x-x-H
SITE 169 169 /note="Essential for degradation by Lon protease" H

Additional information [?]

Size range 168-177 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Due to the high divergence of SulA sequences, this family includes only members from the Enterobacterales. There is a 3D-structure available for SulA from Pseudomonas aeruginosa; this protein is not a member of this family though it probably has the same function; the information derived from the structure was included in this rule. It is not clear whether SulA is located in the cytoplasm or is inner-membrane associated. The sulA gene is interrupted by an insertion sequence in Shigella dysenteriae serotype 1 (strain Sd197).

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