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HAMAP rule MF_01179

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General rule information [?]

Accession MF_01179
Dates 15-MAY-2008 (Created)
7-FEB-2023 (Last updated, Version 13)
Name SulA
Bacteria; Enterobacterales
Templates P0AFZ5 (SULA_ECOLI); Q9HZJ8 (SULA_PSEAE): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Cell division inhibitor SulA;
Gene name

Comments [?]

Function Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division.
Subunit Interacts with FtsZ.
Induction By DNA damage, as part of the SOS response.
Ptm Is rapidly cleaved and degraded by the Lon protease once DNA damage is repaired.
Similarity Belongs to the SulA family.

Keywords [?]

Gene Ontology [?]

GO:0051782; Biological process: negative regulation of cell division.
GO:0006974; Biological process: DNA damage response.
GO:0009432; Biological process: SOS response.

Cross-references [?]

Pfam PF03846; SulA; 1;
TIGRFAMs TIGR00623; Sula; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
REGION     106     112       FtsZ binding     A-L-x-[TS]-G-N-Y  
REGION     162     169       Lon protease binding     [KR]-I-H-S-x-x-x-H  
SITE     169     169       Essential for degradation by Lon protease     H  

Additional information [?]

Size range 168-177 amino acids
Related rules None
Fusion None
Comments Due to the high divergence of SulA sequences, this family includes only members from the Enterobacterales. There is a 3D-structure available for SulA from Pseudomonas aeruginosa; this protein is not a member of this family though it probably has the same function; the information derived from the structure was included in this rule. It is not clear whether SulA is located in the cytoplasm or is inner-membrane associated. The sulA gene is interrupted by an insertion sequence in Shigella dysenteriae serotype 1 (strain Sd197).